Neurological Disorders Autism Guide Autism Guide Symptoms Causes & Risk Factors Diagnosis Treatment Living With In Kids Caregiving Causes and Risk Factors of Autism Spectrum Disorder (ASD) By Toketemu Ohwovoriole Toketemu Ohwovoriole LinkedIn Toketemu has been multimedia storyteller for the last four years. Her expertise focuses primarily on mental wellness and women’s health topics. Learn about our editorial process Updated on October 18, 2021 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Steven Gans, MD Medically reviewed by Steven Gans, MD Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Print Thanasis Zovoilis / Getty Images If you are a parent or loved one of someone with autism spectrum disorder (ASD), you might have wondered what causes it. This question, however, has no straightforward answer because there is no single cause of ASD. Research points to certain risk factors that put some people at a higher risk of developing the condition than others. Risk factors include having a family member who has also been diagnosed with the condition, environmental factors like severe pollution, and being born preterm. What Is Autism? Brain & Body Risk Factors Let's take a look at some risk factors that might increase the likelihood of having autism. Brain Shape and Brain Growth During Development Brain scans of people with autism show that there are differences in certain brain structures as compared to neurotypical people. During early childhood, the brains of children with autism grow faster than usual. They might also have poor connections between brain cells. In children without autism, a process called pruning (where the brain gets rid of connections that aren’t needed to make room for important connections) doesn’t happen as effectively in children with autism. Infection During Pregnancy Some research points at pregnancy being a point at which a child might be susceptible to developing ASD. Bacterial infections during pregnancy have been thought to increase the risk of the unborn child developing ASD, but this is only a slight association and in most cases play no role in the development of this condition. Family History & Genetics Research shows that family history and genetics play a role in the development of the condition. Complications during pregnancy or having children later in life may also play a role. Families With a History of ASD Children with families who have a history of the disorder are at a higher risk of developing it. Even if both parents of a child do not have ASD, they might be carriers of gene changes that cause autism and can be passed on to the child. When a child is diagnosed with ASD, the next child could have up to a 20% chance of developing the condition. And if the first two children in a family have ASD, the third child has about a 32% risk of developing the condition. The way the disorder is transmitted down generational lines is not completely understood. It is impossible to predict who will or won’t get ASD in a family who has a history of the condition. A meta-analysis of studies into how genetics factor into the development of ASD in twins found the overall heritability of ASD to be between 64% to 91%. Neurexin 1 is a gene we all have that plays a vital role in communication in the brain. Some research shows that disruptions with this gene play a factor in the development of autism. However, there is no evidence to support that disruptions with this gene alone are capable of causing autism. There is some evidence to suggest that multiple genes could be involved with ASD. ASD is sometimes associated with other neurodevelopmental disorders such as Down’s syndrome and Fragile X Syndrome. Also, the Reelin gene, which plays an important role in the lamination of the brain during pregnancy, has been associated with autism. Having Children Later in Life Parents who have no family history of the condition but start to have children at an advanced age have a greater risk of their children developing ASD. Pregnancy Complications Pregnancy complications such as multiple pregnancies and preterm pregnancies are also contributing factors. In addition, there has been some research indicating that pregnancies spaced less than a year apart could also put a child at risk of developing ASD. How Genes Influence Child Development Environmental Risk Factors Certain environmental influences could increase the risk of a person developing ASD. In addition, people who are already genetically predisposed to the condition are at an even higher risk when exposed to these environmental factors. Environmental factors also tend to include events that occur after a person is pregnant with a child. For example, some evidence shows that certain anticonvulsants taken during pregnancy might lead to the development of ASD in the child. A vast majority of the research into the causes of ASD focuses on its connection to family history and genetics. However, young children are exposed to thousands of toxic materials in early childhood and during pregnancy. Lifestyle Risk Factors It used to be believed that certain vaccines could cause ASD. However, extensive research has examined this theory, and it has been proven that no vaccines can cause ASD. ASD starts to show as early as 18 months, and because many children are getting different types of vaccines in those early years, the development of ASD has been erroneously linked to taking vaccines. Before more research was done into the causes of ASD, parents of children with ASD were often blamed for causing the condition. Some people even claimed that a lack of attention and care from the parents of a child with ASD could cause the condition. This is untrue, and decades of research have continued to disprove these theories. This theory was prevalent between the 1950s and 1970s when people had very little understanding of ASD and mistook the condition as a psychological disorder instead of a neurodevelopmental brain disorder. No one can point out a single cause for ASD, but it’s never the parents' fault when the condition develops. How Autism Is Treated 9 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Ha S, Sohn I-J, Kim N, Cheon HJS and K-A. Characteristics of brains in autism spectrum disorder: structure, function and connectivity across the lifespan. Experimental Neurobiology. 2015;24(4):273-284. Shen MD, Piven J. Brain and behavior development in autism from birth through infancy. Dialogues Clin Neurosci. 2017;19(4):325-333. doi:10.31887/DCNS.2017.19.4/mshen Columbia University Irving Medical Center. Children with autism have extra synapses in brain. Zerbo O, Qian Y, Yoshida C, Grether JK, Van de Water J, Croen LA. Maternal infection during pregnancy and autism spectrum disorders. J Autism Dev Disord. 2015;45(12):4015-25. doi:10.1007/s10803-013-2016-3 Cleveland Clinic. Autism spectrum disorder (Asd): Causes, symptoms, treatment & outlook. Tick B, Bolton P, Happé F, Rutter M, Rijsdijk F. Heritability of autism spectrum disorders: a meta-analysis of twin studies. J Child Psychol Psychiatry. 2016;57(5):585-95. doi:10.1111/jcpp.12499 Rylaarsdam L, Guemez-Gamboa A. Genetic causes and modifiers of autism spectrum disorder. Front Cell Neurosci. 2019;13:385. doi:10.3389/fncel.2019.00385 Szatmari P. The causes of autism spectrum disorders. BMJ. 2003;326(7382):173-174. doi:10.1136/bmj.326.7382.173 Gerber JS, Offit PA. Vaccines and autism: a tale of shifting hypotheses. Clin Infect Dis. 2009;48(4):456-61. doi:10.1086/596476 By Toketemu Ohwovoriole Toketemu has been multimedia storyteller for the last four years. Her expertise focuses primarily on mental wellness and women’s health topics. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? 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