Bipolar Brain vs. Non-Bipolar Brain: Key Differences

Most people probably think of bipolar disorder as a psychiatric disorder, but it is also considered a neurological disorder. This is because the expression of the genes associated with bipolar leads to chemical, structural, and functional neurological differences from a brain that doesn’t have bipolar.

Here’s a look at how the brain of someone with bipolar disorder might differ from someone who doesn’t have bipolar, including people with unipolar depression. 

Brain Structure

First, a little bit of background information on the brain in general. It is made up of four lobes, each responsible for governing different brain functions.

• Frontal: This is the largest lobe of the brain and is involved with personality characteristics, decision-making, and movement. 
• Parietal: This middle part of the brain helps someone identify objects and understand where things exist spatially. It also decodes pain and touch in the body. Additionally, it helps the brain understand oral language.
• Temporal: This area, on the sides of the brain, involves short-term memory, speech, musical rhythm, and smell recognition. 
• Occipital: This part of the brain involves vision.

Gray matter is the darker, outer material surrounding the brain. It is responsible for processing and interpreting information.

White matter is the lighter section beneath the brain. White matter communicates that information to other parts of the nervous system. 

Structural Differences

Studies have shown reduced gray matter in people with bipolar, and these deficits are most pronounced in the areas of the brain controlling inhibition and motivation—frontal and temporal regions. Those with a history of psychosis do have less gray matter, but if they took Lithium or another anti-epileptic/antipsychotic, they showed signs of reversing that.

Bipolar disorder may be considered a neurodegenerative disease, as the longer someone has been dealing with it, the less cortical thickness they showed in frontal, medial parietal and occipital regions.

These frontal and temporal lobe differences are partially heritable and traceable to the pathophysiology (how disease affects one physically) of bipolar disorder. Additionally, lifestyle factors such as alcohol use, smoking, and other substance use may affect cortical structure.

Brain Function

Of course, if bipolar disorder is literally changing the brain’s structure, it will also change and affect how it functions. If you have bipolar or know someone who does, you probably know this intuitively, but here’s what that actually looks like. 

• Bipolar disorder can be a neuroprogressive disease, meaning changes in the brain lead to a more severe course of illness as well as neurocognitive deterioration. As a disease/disorder neuroprogresses, it leads to less neurogenesis, or fewer neurons developing in the brain. Developing new neurons is important because they help the brain respond to the cognitive load it faces. 

• Changes occur on two levels in bipolar (and other disorders)—state changes and trait changes. State changes are symptoms that one might experience during a manic or depressive episode that are temporary, whereas trait changes are enduring changes that last even in remission/recovery from episodes. An example of a trait marker/change is someone with bipolar disorder still experiencing heightened emotionality in a time or area where one would likely be having neutral or “cold” emotions.

Neurocognitive function deficits are seen in three core domains: 

Attention

In one study, patients with bipolar disorder were asked to monitor a stream of stimuli in order to identify a certain one—to measure their ability to hold sustained attention. Patients in states of mania struggled more than patients who were not in a state of mania to complete this test, as well as committing more false alarms, and responding to non-target stimuli.

Executive Function

Executive function refers to a number of psychological processes that allow for organization, planning, and working memory—processes related to the health of the prefrontal cortex. Of any symptom, a lack of executive function may hinder most patients’ abilities to participate in their everyday life—and thus affect their quality of life.

Emotional Processing 

In struggles with executive functioning, it is usually the dorsal and lateral aspects of the prefrontal cortex that are affected; the orbital frontal cortex (which sits at the very front of the brain) is linked to emotional processes such as reward evaluation, risky decision-making, and impulse control.

When this area is damaged, there are typically changes in emotional behavior as well as impaired or impulsive judgment and great difficulty evaluating others’ facial expressions. Tests show a lack of impulse control. However, the study also showed that when in remission, these functions recovered substantially, showing that they are maybe related to the manic state. 

Brain Chemistry 

Though the idea of a “chemical imbalance” may be controversial, what is less controversial is that bipolar disorder certainly affects the brain chemically. Research shows that people with bipolar disorder have a distinct “chemical signature” (set of common levels of certain biomarkers). 

However, the research also showed that this signature could be reversed by lithium and valproic acid, two common medications used to treat bipolar. They are thought to work by restoring the balance of these neurotransmitters in the brain.

• Glutamate is an excitatory neurotransmitter that helps neurons communicate. It is present in upwards of 90% of all synapses in the brain. Its actions at the synapse (communications hub of neurons) can either boost or weaken the communication signal. Too much glutamate, as seen in mania, damages nerve cells and the communications network. In depression, it leads to symptoms such as anhedonia and lethargy.
• Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that blocks certain brain signals to decrease activity in your nervous system, including the messages that signal fear, anxiety, or stress. In bipolar, GABA levels often may be dysregulated, either appearing too high or too low, but this seems to be an association, not a direct cause of certain symptoms. However, medications used to treat bipolar, such as lithium, regulate this.

Brain-derived neurotrophic factor (BDNF) is a protein that promotes neuron growth/survival/helps establish neuronal connections. BDNF regulates complex cognitive functions in a healthy brain, such as learning and memory. It is usually found in an area of the brain that controls eating, drinking, and body weight.

A Word From Verywell

Although bipolar disorder can affect the brain in significant ways, it is treatable (if not curable), and many of the medications prescribed to treat it may mitigate many of the cognitive concerns.