Addiction Coping and Recovery Overcoming Addiction What to Know About Campral (Acamprosate) A Drug Used to Support Alcohol Use Recovery By Buddy T Buddy T Facebook Twitter Buddy T is an anonymous writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. Learn about our editorial process Updated on May 19, 2023 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Daniel B. Block, MD Medically reviewed by Daniel B. Block, MD LinkedIn Twitter Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Learn about our Medical Review Board Print Table of Contents View All Table of Contents How It Worked Before Taking Dosage Side Effects Warnings and Interactions Frequently Asked Questions Although Campral tablets were discontinued in 2014, the generic version of this drug (acamprosate) is still available, making this information important to know if you've been prescribed the generic form. Quitting alcohol can lead to symptoms of anxiety, insomnia, and restlessness, causing people to feel tempted to return to this drug. A medication called acamprosate—formerly sold under the brand name Campral—may help by restoring the balance of the brain's neurotransmitters, which eases symptoms and reduces cravings. The Food and Drug Administration (FDA) approved Campral in 2004 to treat alcohol dependence after having been used widely in Europe for many years. Campral is no longer available under its brand name, but it is still available in the generic form acamprosate. How Campral Worked The acamprosate in Campral helped a person who has given up drinking to maintain sobriety by reducing their desire for alcohol. It worked by restoring the chemical balance in the brain that is disrupted by long-term or chronic alcohol misuse. When a person drinks heavily or frequently, the balance of neurotransmitters in the brain changes. Specifically, the excitatory neurotransmitter glutamate is decreased, creating a sedative effect. When they quit drinking, glutamate increases, resulting in central nervous system hyperactivity and excitability. This can cause the person to crave alcohol. Acamprosate is thought to inhibit the release of glutamate and activate taurine, an inhibitory neurotransmitter. Ultimately, this decreases the level of excitation the person experiences. Acamprosate can also help reduce many of the post-acute withdrawal symptoms that many people experience during the early stages of alcohol abstinence. This includes easing symptoms such as sweating, anxiety, and sleep disturbances. Acamprosate vs. Other Medications Used to Treat Alcohol Dependence There are several medications that can be used to treat alcohol dependence. Each one works a little differently. For example, Antabuse (disulfiram) works by making someone sick if they drink alcohol and naltrexone blocks the "high" people get when drinking. But acamprosate reduces the physical distress and emotional discomfort people usually experience when they quit drinking. Acamprosate does not help someone quit drinking. But, it can help those who have already withdrawn from alcohol to maintain abstinence. Acamprosate does not help with withdrawal symptoms experienced while going through early detoxification from alcohol. However, it has been shown to reduce sleep disturbances commonly experienced during early sobriety by people recovering from alcohol use disorder. As with all other medications approved for the treatment of alcohol dependence, acamprosate is most effective as a part of an overall program of recovery including therapy, counseling, and/or support group participation. Before Taking Acamprosate Talk to your physician about all medications, supplements, and vitamins that you currently take. While some drugs pose minor interaction risks, others may contraindicate use or prompt careful consideration as to whether the pros of treatment outweigh the cons in your case. People who have stopped drinking alcohol can take acamprosate. This medication does not work for people who continue to drink, nor does it work for those who use illicit drugs or misuse prescription medications. It is important to recognize that acamprosate is not a standalone treatment for alcohol addiction. Treatment for alcohol withdrawal should only be provided by a trained healthcare professional as symptoms can range from uncomfortable to life-threatening. Precautions and Contraindications Taking acamprosate can cause drowsiness, dizziness, and decreased alertness in some people. For this reason, it is important to determine how the medication will affect you before operating a motor vehicle. Acamprosate should not be taken if you have any of the following conditions: Allergic reaction to Campral, sulfites, or other medicinesAllergic reaction to foods, dyes, or preservativesBreastfeedingDepressionKidney diseasePregnant or trying to get pregnantSuicidal thoughts If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911. For more mental health resources, see our National Helpline Database. 988 Dosage of Campral Acamprosate is typically prescribed in 333 mg time-release tablets, with two tablets (666 mg total) taken three times a day. Although, some people receive benefits with lower doses. Because the side effects of acamprosate are few and mild, and because acamprosate is not addictive, it is usually prescribed for up to 12 months after ceasing alcohol consumption. How to Take and Store In case of a missed dose of acamprosate, the medication should be taken as soon as possible. However, if it is almost time for the next dose, people should skip the missed dose and take the next dose as they usually would. Never take two doses of acamprosate to make up for a missed dose. Acamprosate is usually taken three times per day, but always follow your healthcare provider's recommendations. The tablets can be taken with or without food. Because the tablets are time-released, they should be swallowed whole and never crushed, cut, or chewed. The medication should be stored away from heat, moisture, or direct light and kept in a closed container. It should also be kept out of the reach of children. Always discard any outdated medications. Side Effects of Campral People taking Campral sometimes experienced side effects. In some cases, these effects were common and mild while, for others, the side effects of Campral were more severe. Common Side Effects Campral was generally well-tolerated and the side effects that were reported were usually mild and temporary, including: DiarrheaDizzinessDry mouthGasHeadachesInsomniaItchingJoint or muscle painLoss of appetiteSweatingVomiting Severe Side Effects In rare cases, acamprosate can cause more severe side effects. Two potential side effects of this drug that can be serious enough to require medical attention are rash and burning, tingling, or numbness in the extremities (hands, feet, arms, or legs). If you or someone you know experiences either of these serious symptoms after taking acamprosate, stop taking the medication immediately and contact your healthcare provider. Warnings and Interactions for Campral Research has not indicated negative effects with the long-term use of acamprosate. While there are no known interactions that will alter the effects of the medication, you should always talk to the prescribing physician about any medications, supplements, or substances that you are taking. Acamprosate is contraindicated in people with severe kidney impairment. However, it can be prescribed to those with mild to moderate liver dysfunction. If you have impaired kidney function, your healthcare provider may prescribe a lower dose or recommend that you not take acamprosate. What to Expect While Recovering From Alcohol Use Frequently Asked Questions How long does Campral take to work? Acamprosate is slow to absorb, so it acts as a modified-release medication. It takes around six hours for it to reach its maximum concentrations in the body, and about five days for it to reach a steady state. You may begin experiencing the effects of the medications sooner, however. How much does Campral cost? Medication costs vary depending on the pharmacy. The cost of acamprosate may be covered by your insurance depending on your prescription coverage. How long can you take Campral? There are no associated risks of long-term use, but acamprosate is often taken for between three and 12 months. What are the risks of acamprosate (Campral)? Campral was considered safe, well-tolerated, and effective when taken as prescribed. Side effects tended to be mild, but some people experienced more serious side effects such as rash or burning, tingling, or numbness in the extremities. Always contact your physician if you experience any concerning side effects while taking a medication. 12 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. American Society of Health-System Pharmacists. Acamprosate calcium tablets. U.S. Food & Drug Administration. Drug approval package: Campral (acamprosate calcium) delayed-release tablets. Witkiewitz K, Saville K, Hamreus K. Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility. Ther Clin Risk Manag. 2012;8:45-53. doi:10.2147/TCRM.S23184 Plosker GL. Acamprosate: A review of its use in alcohol dependence. Drugs. 2015;75(11):1255-68. doi:10.1007/s40265-015-0423-9 Staner L, Boeijinga P, Danel T, et al. Effects of acamprosate on sleep during alcohol withdrawal: A double-blind placebo-controlled polysomnographic study in alcohol-dependent subjects. Alcohol Clin Exp Res. 2006;30(9):1492-9. doi:10.1111/j.1530-0277.2006.00180.x U.S. Food and Drug Administration. CAMPRAL® (acamprosate calcium) Delayed-Release Tablets. National Institute of Diabetes and Digestive and Kidney Diseases. Acamprosate. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Mason BJ, Ownby RL. Acamprosate for the treatment of alcohol dependence: a review of double-blind, placebo-controlled trials. CNS Spectrums. 2000;5(2):58-69. doi:10.1017/S1092852900012827 Yahn SL, Watterson LR, Olive MF. Safety and efficacy of acamprosate for the treatment of alcohol dependence. Subst Abuse. 2013;6:1-12. doi:10.4137/SART.S9345 MedlinePlus. Acamprosate. National Alliance on Mental Illness. Acamprosate (Campral). Kalk NJ, Lingford-Hughes AR. The clinical pharmacology of acamprosate. Br J Clin Pharmacol. 2014;77(2):315-23. doi:10.1111/bcp.12070 By Buddy T Buddy T is an anonymous writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? 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