Depression Treatment Medication How Antidepressants Show Up on a Drug Test Avoiding a False Positive Result on a Drug Screen By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial process Nancy Schimelpfening Medically reviewed by Medically reviewed by Steven Gans, MD on June 18, 2020 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Review Board Steven Gans, MD Updated on June 18, 2020 Print Kirby Hamilton/Getty Images Table of Contents View All Drug Screen Types Antidepressants Preventing False Positives Protecting Your Privacy Preparing for the Test If you have depression and are taking a prescription medication like Prozac, you might worry that it could show up on a drug test. This is especially a concern if you must take a pre-employment drug screen for a new job. Because antidepressants are not considered drugs of abuse, they are not included in common urine drug screens. However, there may be cross-reactions that can produce false positive results for the substances these tests are designed to detect. Learn the actions you can take to ensure your results are interpreted accurately and your rights are protected. Common Drug Screens If you are in treatment for depression, the good news is that antidepressants are not the drugs that an employer is looking for in an employment drug screen. The lab would have to do specific additional tests to look for antidepressants. The types of substances tested for on a typical employment drug screens include: Amphetamines, including methamphetamineBarbituratesBenzodiazepines (tranquilizers)Cannabinoids, including marijuanaCocaineDarvon (propoxyphene)Opiates, including heroin, oxycodone, and hydrocodonePhencyclidine (PCP) Impact of Antidepressants False positive test results can sometimes occur if a prescription drug or its metabolite has a similar chemical structure to the target drug being tested for. Some antidepressants can inadvertently trigger a false positive for a controlled substance. To avoid this, advise the tester about any drugs you may be taking so that confirmatory tests can be performed to weed out any false positive. Certain antidepressant drugs are more prone to false-positive readings. For example, Wellbutrin (bupropion), Prozac (fluoxetine), and Desyrel (trazodone) can all potentially show up as amphetamines in a drug screen. Similarly, Zoloft (sertraline) may show up as a benzodiazepine. Less commonly, antidepressants have been known to trigger false positives for LSD. Preventing False Positives If you are concerned that your antidepressant might show up as a false positive, your best course of action is to be proactive. In addition to informing the technician about your antidepressant use, bring along the prescription bottle and ensure that the drug is notated on your record. It is better to declare this before the test rather than after. Due to the risk of false positives, all drug screen results should be considered presumptive until confirmed by a second testing technique, such as liquid or gas mass spectrometry. If your drug screen is positive and a second confirmation test has not been done, demand that it be performed immediately, ideally with the same sample. Moreover, get a copy of both results to confirm that a different technique was used. Protecting Your Privacy Even if you are able to sort out any false positives from your drug screen, you may be concerned about the disclosure of your antidepressant drug use. In most cases, any information you share with the tester won't be included on the result. The employees at the lab and your present or future supervisor will likely have no direct contact with each other. All your employer will receive is a list of positive and negative results to the requested drug screens. Workplace harassment and discrimination for depression and other mental health conditions are prohibited under the Americans With Disabilities Act, but you may have valid concerns about your rights being upheld. If you're concerned about confidentiality, ask the tester for a copy of the company's protected health information (PHI), outlining their legal duties and privacy practices as directed by the Health Insurance Portability and Accountability Act (HIPAA). Although awareness about mental health conditions such as depression has grown over the years, it is still common for people with depression to worry about the stigma associated with a depression diagnosis. It is fully understandable that you would want your depression diagnosis to be kept private, especially from a current or prospective employer. You may fear you could be discriminated against or singled out for the condition in the workplace, even with the legal protections in place. Could You Have Smiling Depression? Preparing for the Test First and most importantly, do not stop taking your medications or reducing the dosage unless you are doing so under the guidance of your physician. This is true even if you are concerned about false positives. Even short-term interruptions can have serious consequences for the treatment of your condition, not least of which is antidepressant discontinuation syndrome (ADS). Discuss any concerns you have with your mental health provider so you can take the drug screen safely and without stress. It is also important to remember that antidepressants aren't the only drugs that can trigger a false positive drug screen. Others include: Advil (ibuprofen)Aleve (naproxen)Benadryl (diphenhydramine)Cardizem (diltiazem)Dextromethorphan (found in Robitussin)Glucophage (metformin)Ritalin (methylphenidate)Sudafed (pseudoephedrine)Trandate (labetalol)Ultram (tramadol) A Word From Verywell Facing a drug screen can make anyone anxious, especially when it is required for a job. You are not alone if you feel this way. However, try not to stress unduly about taking a drug screen. Remember that false positives do happen and that most drug screening companies understand this. Simply divulge your prescriptions so that false positives can be avoided and your rights can be preserved. Debating Workplace Drug Screening Was this page helpful? Thanks for your feedback! Everything feels more challenging when you're dealing with depression. Get our free guide when you sign up for our newsletter. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Substance Abuse and Mental Health Services. Drug testing. Updated November 2, 2015. Casey ER, Scott MG, Tang S, Mullins ME. Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay. J Med Toxicol. 2011;7(2):105-8. doi:10.1007/s13181-010-0131-5 Olmstead: Community Integration for Everyone. Ada.gov. Published 2019. Warner CH, Bobo W, Warner C, Reid S, Rachal J. Antidepressant discontinuation syndrome. Am Fam Physician. 2006;74(3):449-56. Additional Reading Moeller KE, Lee KC, Kissack JC. Urine drug screening: practical guide for clinicians. Mayo Clinic Proceedings. 2008;83(1):66-76. doi: 10.4065/83.1.66. Nasky KM, Cowan GL, Knittel DR. False-positive urine screening for benzodiazepine: An association with sertraline? Psychiatry (Edgemont). 2009 Jul;6(7):36-9. U.S. Equal Employment Opportunity Commission. Depression, PTSD, and Other Mental Health Conditions in the Workplace: Your Legal Rights. Washington, D.C.