Schizophrenia What Is Catalepsy? By Kendra Cherry Kendra Cherry Facebook Twitter Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology. Learn about our editorial process Published on December 21, 2021 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Shaheen Lakhan, MD, PhD, FAAN Medically reviewed by Shaheen Lakhan, MD, PhD, FAAN Shaheen Lakhan, MD, PhD, is an award-winning physician-scientist and clinical development specialist. Learn about our Medical Review Board Print Westend61 / Getty Images Table of Contents View All Table of Contents What Is Catalepsy? Signs of Catalepsy Identification Causes Treatments How to Cope What Is Catalepsy? Catalepsy Catalepsy involves a loss of voluntary motion, muscle rigidity, fixed posture, and decreased sensitivity to pain. It is a symptom of a number of conditions including epilepsy, Parkinson's disease, substance use, catatonia, schizophrenia, and as a side effect of some types of medication used to treat schizophrenia. This article discusses some of the signs that someone is experiencing catalepsy, the conditions that may cause this symptom, and how it might be treated. Signs of Catalepsy Some of the signs of catalepsy include: Decreased or slowed movementDecreased muscle controlDecreased sensitivity to pain Loss of muscle controlRigid body postureRigid limbsSlowed breathingSlowed body functionsWaxy flexibility (limbs remain in the same position when moved) Waxy flexibility is associated with conditions such as bipolar disorder and schizophrenia. People experiencing this symptom only slightly resist having their body or limbs moved into a different position. The individual will then remain in this new position without making any attempts to reposition the body. People who are experiencing catalepsy are less sensitive not only to pain but to touch in general. When a person is experiencing this symptom, they seem non-responsive and do not respond to speech. Identifying Catalepsy If a person is experiencing catalepsy, a doctor may observe this symptom and consider a person’s medical history and other symptoms in order to make a diagnosis. A doctor may perform a physical exam and run lab tests to look at factors that may be contributing to a person’s symptoms. The diagnosis that a doctor makes will depend on what other symptoms a person is experiencing. For example, a person who experiences catalepsy along with echolalia, stupor, and mutism might be diagnosed with catatonia. Causes of Catalepsy Catalepsy is not a distinct condition in and of itself but is instead a symptom of some types of nervous disorders and other conditions. Some of the conditions that may cause catalepsy include: CatatoniaCocaine withdrawalEpilepsyKetamine useParkinson's disease According to a 2013 study, catalepsy results from the blockage of certain dopamine receptors in the neural circuits associated with motor behavior. It can also occur as a side effect of some antipsychotic medications that are used to treat schizophrenia and bipolar disorder, including haloperidol. This side effect can play a role in medication adherence for people with schizophrenia. Catalepsy accompanied by waxy flexibility or rigid, immobile limbs was once a staple of stage hypnosis. Hypnotists would suggest that the individual could not move and then position the individual poses that the individual would remain in until the hypnotist ended the hypnotic trance. Treatment for Catalepsy The treatment for catalepsy depends on the underlying condition that is causing this symptom. Once a diagnosis has been made, healthcare providers will recommend treatments to address the underlying cause. Cases of catalepsy caused by stress or trauma often ease over time. In such cases, psychotherapy may also be helpful. Some treatments that might be used to help ease catalepsy include: Antipsychotic medications: If catalepsy is connected to a psychotic disorder such as schizophrenia or catatonia, an antipsychotic medication may be prescribed. Muscle relaxants: Some people may find that muscle relaxants help reduce the muscle, limb, and postural rigidity caused by catalepsy. Research has also indicated that adenosine antagonists might be useful in the treatment of haloperidol-induced catalepsy. In one study, caffeine, a non-selective adenosine antagonist, was found to significantly reduce catalepsy and improve movement. One 2018 study found that deep brain stimulation (DBS) was effective in relieving haloperidol-induced catalepsy in individuals with Parkinson's disease. Deep brain stimulation is a surgical technique in which a device is implanted inn specific areas of the brain in order to deliver small electrical shocks. Other treatments may be on the horizon as researchers learn more about the causes of catalepsy. In a 2020 study published in Translational Psychiatry, researchers found that haloperidol-induced catalepsy is caused by an area of the brain call the striatum. What Is the Striatum? The striatum is an area of the brain that plays a vital role in facilitating voluntary movement. The striatum directs information and instructions to the basal ganglia, which then initiates movement. According to the results of the research, a key protein known as mTOR plays a pivotal role in dopamine 2 signaling. When this protein is over-produced or under-produced in the brain’s striatum, it can contribute to serious disorders and problems such as catalepsy. The study also found that a medication used to prevent rejection in organ transplants and other procedures can prevent or remedy cases of catalepsy induced by haloperidol. The use of this medication to treat this type of catalepsy was discovered by accident. Researchers were using haloperidol and rapamycin in their studies of the striatum when they noticed the effect. While promising, it is important to note that more research is needed to better understand how such treatments might be best utilized. There is currently no FDA-approved treatment specifically for catalepsy. It is often treated by addressing the underlying condition that is causing this symptom. New treatments may be discovered as researchers continue to discover the brain structures and chemicals that might be involved in producing catalepsy. Coping With Catalepsy If you believe someone is experiencing catalepsy, you should seek medical attention. Catalepsy can be potentially dangerous and a person exhibiting signs should be evaluated to help ensure their safety. A healthcare provider can then determine what might be contributing to this symptom and provide treatments that can help. For catalepsy caused by substances such as cocaine or ketamine, symptoms will usually resolve with time. People who are experiencing withdrawal symptoms should consult a doctor, however. A healthcare provider can supervise the detox process and may be able to prescribe medications that can help you detox safely with fewer withdrawal symptoms. For catalepsy caused by other conditions such as Parkinson’s disease or epilepsy, your doctor will work with you to develop a treatment plan that is right for your needs. A Word From Verywell Catalepsy can be a serious and concerning symptom of a number of health conditions. If you or someone you love is experiencing this symptom, your first step should be to seek medical attention for the appropriate diagnosis and treatment. How to Deal With Withdrawal Symptoms 5 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Rasmussen SA, Mazurek MF, Rosebush PI. Catatonia: Our current understanding of its diagnosis, treatment and pathophysiology. World J Psychiatry. 2016;6(4):391-398. doi:10.5498/wjp.v6.i4.391 Colombo AC, de Oliveira AR, Reimer AE, Brandão ML. Dopaminergic mechanisms underlying catalepsy, fear and anxiety: do they interact? Behav Brain Res. 2013 Nov 15;257:201-7. doi:10.1016/j.bbr.2013.10.002 Trevitt J, Vallance C, Harris A, Goode T. Adenosine antagonists reverse the cataleptic effects of haloperidol: implications for the treatment of Parkinson's disease. Pharmacol Biochem Behav. 2009;92(3):521-7. doi:10.1016/j.pbb.2009.02.001 Engelhardt KA, Marchetta P, Schwarting RKW, Melo-Thomas L. Haloperidol–induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus. Sci Rep. 2018;8(1):2216. doi:10.1038/s41598-018-19990-y Ramírez-Jarquín, U.N., Shahani, N., Pryor, W. et al. The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior. Transl Psychiatry. 2020;10;336. doi:10.1038/s41398-020-01014-x By Kendra Cherry Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? 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