Bipolar Disorder Bipolar Disorder Not Otherwise Specified (NOS) When a diagnosis is suggestive rather than indicative of bipolarity By Marcia Purse Marcia Purse Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. Learn about our editorial process Updated on August 06, 2022 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Daniel B. Block, MD Medically reviewed by Daniel B. Block, MD LinkedIn Twitter Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Learn about our Medical Review Board Print Laurence Mouton / Getty Images Bipolar disorder not otherwise specified (NOS) is one of those psychiatric terms that can cause more confusion than clarity, especially to the person being diagnosed. Bipolar disorder NOS is usually diagnosed when a patient shows some symptoms of bipolar disorder but doesn't necessarily meet all the criteria as outlined in the Diagnostic and Statistical Manual of Mental Disorders. The term bipolar disorder NOS was used in the fourth edition of the DSM (DSM-IV); however, the DSM-5 actually uses the terms "unspecified bipolar and related disorder" or "other specified bipolar and related disorder" to diagnose conditions that were previously called bipolar disorder NOS. What Not Otherwise Specified Means Bipolar disorder NOS is more of a catch-all category than an actual type of bipolar disorder. Your doctor may use the classification to document symptoms which are consistent with bipolar disorder but fall short of the criteria needed to make a definitive diagnosis. In general, NOS is most commonly ascribed when a mood disorder is characterized by depression alternating with short episodes of hypomania (a milder form of mania). Oftentimes, the mood swings are rapid, occurring within days of each other. By and large, children and adolescents are most frequently diagnosed with NOS as they will be least likely to have a previous history of mood dysfunction. From a psychiatric standpoint, bipolar disorder NOS is taken just as seriously as any other form of mood disorder. It presumes that there is a concern and that it likely will be more definitively diagnosed in the future. By assigning the NOS diagnosis now, the person will be less likely to slip through the cracks should another mood episode occur. Still, there remains contention in the psychiatric community as to whether bipolar disorder NOS is a valid diagnosis or if it may lead to the premature treatment or over-treatment of an otherwise presumptive illness. Unspecified vs. Specified Bipolar Disorder As mentioned, the American Psychiatric Association (APA) prefers the terms unspecified or other specified for bipolar disorder to better reflect the uncertainty of the diagnoses. (The terms unspecified and other specified are also used for types of depressive disorders in the DSM-5). Other specified bipolar disorder may be diagnosed when a person displays specific symptoms of bipolar (such as manic and/or depressive episodes), but the full criteria for those symptoms aren't met. Unspecified bipolar may be the diagnosis when a person's symptoms resemble the symptoms of bipolar disorder, but the clinician chooses not to specify the reason the criteria are not met for a specific bipolar disorder, such as in an emergency room where there is insufficient information to make a more specific diagnosis. What Does Depressive Disorder NOS Mean? Diagnostic Criteria The Diagnostic and Statistical Manual of Mental Disorders (DSM) issued by the APA does provide examples as to when it may be appropriate to diagnose bipolar disorder NOS (or as they call it, other specified/unspecified): The person has experienced alternating manic or depressive symptoms, but the episodes are too short to meet the criteria for inclusion. The person has experienced both hypomania and depression, but the episodes are too short to qualify as a cyclothymic disorder. The person may have had multiple episodes of hypomania but no depressive episode. Differential Diagnoses Any informed diagnosis of bipolar disorder NOS would involve a review of all other possible causes. In the event that substance abuse or an undiagnosed medical condition is suspected, further investigations may be ordered, including blood tests, a drug screen, neurological imaging, or other diagnostic techniques to identify an infection, injury, or malignancy. The doctor should also consider other psychiatric conditions that closely mimic bipolar disorder NOS. One such example is disruptive mood dysregulation disorder (DMDD), a condition seen in children and adolescents which is characterized by a persistently irritable or angry mood accompanied by frequent temper outbursts that are disproportionate to the situation. Unlike bipolar disorder NOS, DMDD does not have distinct manic episodes but is rather defined by the persistence of irritability and temper. Current research strongly suggests that DMDD is, in fact, not a form of bipolar disorder and that children with DMDD are not at a particularly high risk of developing bipolar disorder as they get older. Treatment Specific treatments for bipolar disorder NOS are not as well researched. However, they are generally the same as for other bipolar and related disorders—including mood stabilizers and psychotherapy. Most experts agree that psychotherapy can be beneficial to anyone deemed at risk of developing symptoms of bipolar disorder, ideally starting early. A Word From Verywell While the NOS diagnosis can be frustrating for anyone looking for a more definitive diagnosis for their mood symptoms, it is often about your clinician trying to be precise in the application of established diagnostic criteria for particular disorders. Often, the diagnosis will become clearer over time. For example, it is not uncommon that someone initially diagnosed with a depressive disorder may ultimately turn out to have a bipolar and related disorder diagnosis at some point down the road. 4 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Parker G. DSM-5 and psychotic and mood disorders. J Amer Acad Psychiatry Law. 2014;42(2):182-190. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Arlington, VA: American Psychiatric Association, 2013. National Alliance on Mental Illness. Bipolar disorder. Swartz HA, Swanson J. Psychotherapy for Bipolar Disorder in Adults: A Review of the Evidence. Focus (Am Psychiatr Publ). 2014;12(3):251–266. doi:10.1176/appi.focus.12.3.251 Additional Reading Leboyer M, Kupfer D. Bipolar disorder: new perspectives in health care and prevention. J Clin Psychiatry. 2010:71(12):1689-95. doi:10.4088/JCP.10m06347yel. By Marcia Purse Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Speak to a Therapist Online Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.