Depression Treatment How Is Transcranial Magnetic Stimulation (TMS) Used to Treat Depression? By Elizabeth Plumptre Elizabeth Plumptre LinkedIn Elizabeth is a freelance health and wellness writer. She helps brands craft factual, yet relatable content that resonates with diverse audiences. Learn about our editorial process Published on October 31, 2021 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Steven Gans, MD Medically reviewed by Steven Gans, MD Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Print PeopleImages / Getty Images Table of Contents View All Table of Contents What Is Transcranial Magnetic Stimulation? What to Expect During TMS Therapy How Does TMS Treat Depression? Who Can Receive Transcranial Magnetic Stimulation? Side Effects of rTMS Depression is one of the most common mental health conditions. At least 17.3 million American adults have had at least one depressive episode. These episodes are usually marked by persistent feelings of sadness, hopelessness, apathy, irritability, fatigue, and even suicidal thoughts. To manage these symptoms, therapy and medication are commonly recommended. However, there are cases where these treatments fail to provide relief or are not tolerated. In such instances, measures like Transcranial Magnetic Stimulation (TMS) may be used. For those who find their depression to be treatment-resistant, TMS may help with managing their condition. This treatment can potentially provide relief from mental health disorder symptoms. If you or a loved one are struggling with depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area. For more mental health resources, see our National Helpline Database. What Is Transcranial Magnetic Stimulation? TMS is a non-invasive procedure that applies strong magnetic fields to certain parts of the brain. For example, TMS can stimulate the prefrontal cortex (one area of the brain responsible for regulating mood) to help improve your overall mental state. For this procedure to garner positive results, it requires magnetic pulses to be applied repetitively to the nerve cells in regions of the brain. This is why it is sometimes called repetitive transcranial magnetic stimulation (rTMS). Recognizing its effects on depression, the Food and Drug Administration (FDA) has accepted TMS as a viable treatment option for the condition under certain circumstances. In addition, this treatment has shown some promise in managing conditions like bipolar disorder, obsessive-compulsive disorder, Alzheimer’s disease, schizophrenia, and others. What to Expect During Transcranial Magnetic Stimulation Therapy As stated, TMS is non-invasive, which means no anesthesia or surgical incisions are required for this procedure. Instead, a coil is placed on the scalp, which produces the powerful electromagnetic fields delivered to the brain's specified region. A physician or technician will determine the best location for maximum effect and then place the coil there. Placement of the coil is important because it must align with the part of the brain involved with the patient’s condition. The coil is placed while the patient is seated (this position is maintained for the duration of the therapy). While seated, the patient must be free of any jewelry or magnet-sensitive objects. People familiar with MRI machines may experience a similar ticking sound when they start TMS treatments. This sound is produced by the magnetic fields being projected to the brain. Because of this noise, patients may wear earplugs while receiving this therapy for noise-canceling and safety purposes. The patient may also feel some tapping while wearing the treatment coil. TMS sessions usually last for about a four- to six-week period, and the patient may receive treatment five times a week. Depending on the coil used and the magnetic pulses delivered to the brain, sessions can last between 30 and 40 minutes. However, the number of sessions may change depending on the patient's response or the severity of the patient’s condition. How Does Transcranial Magnetic Stimulation Treat Depression? While the exact mechanism of action isn’t clear, it is believed that repetitive TMS produces effects similar to antidepressants and electroconvulsive therapy. In addition to the prefrontal cortex, a depressed brain will also report decreased activity in areas like the frontal lobe, amygdala, and hippocampus—regions that affect emotions and mood. By sending in targeted magnetic waves, these brain regions may have increased activation. Repetitive TMS has also been shown to increase dopamine in certain brain regions. This is helpful because dopamine (the pleasure hormone) is an important neurotransmitter involved in the regulation of mood. TMS has been found to benefit between 50%-60% of people who failed to observe improvements after using medication alone to manage their depression. In addition, a study has shown that, in combination with therapy, 66% of TMS patients had a positive response to the treatment. And, 56% of patients' symptoms went into remission. This shows that TMS is a useful supplement to therapy in people who have treatment-resistant depression. However, while improvements in symptoms may occur, these effects are not permanent. There is a chance that depression symptoms will return after a while, so additional rounds of treatment may be necessary. Who Can Receive Transcranial Magnetic Stimulation? Anyone with depression who finds medication, therapy, and their combination ineffective for treatment may consider TMS. Studies have consistently demonstrated that electroconvulsive therapy (ECT) is the most effective intervention for treatment resistant depression, however unlike TMS, it requires anesthesia and comes with greater potential side effects. However, depressed patients with unremovable metal objects like metallic tattoos, certain brain stents, or monitoring electrodes in their heads may be excluded from this treatment. This is because the strong magnetic pulses may cause the metal to heat up, move, or malfunction. The field may even cause serious injury in some instances. Patients with tooth fillings or braces are, however, able to receive this treatment. Side Effects of rTMS Transcranial magnetic stimulation is a relatively safe procedure. Its non-invasive approach, high tolerability, and minimal risk make it safe enough for use in children, although more research is needed in this area. Likewise, these features make TMS safe, even for pregnant people. Older populations can also benefit from TMS therapy because of its safety and because TMS therapy has a low risk of interacting with medication. However, minor side effects like pain in the scalp and headaches have been observed in patients that have received this treatment. You might experience fewer side effects as you continue to go through treatment or take any recommended medication. Patients have also reported hearing issues immediately following the loud noise produced by the pulses. This is despite earplugs being administered during the procedure. The most serious side effect of this process, however, is a chance of experiencing seizures. However, this risk is considerably low. A Word From Verywell Transcranial magnetic stimulation can be a game-changer for the management of treatment-resistant depression. Its non-invasive technique and low risk of side effects may make it a choice treatment for certain patients struggling with the symptoms of depression. While there is evidence to support its positive effects in improving mood, more research is required to properly identify the mechanisms of action and likely effects of this treatment. 8 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. National Institute of Mental Health. Depression. 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Published 2019 Aug 12. doi:10.1136/gpsych-2019-100074 Chail A, Saini RK, Bhat PS, Srivastava K, Chauhan V. Transcranial magnetic stimulation: A review of its evolution and current applications. Ind Psychiatry J. 2018;27(2):172-180. doi:10.4103/ipj.ipj_88_18 By Elizabeth Plumptre Elizabeth is a freelance health and wellness writer. She helps brands craft factual, yet relatable content that resonates with diverse audiences. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Speak to a Therapist for Depression Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.