Using Marijuana to Treat Depression

Cannabis plant
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With states across the nation passing laws allowing for the medical use of marijuana, much debate has ensued over which conditions should qualify patients for approved use. Depression is one such condition that has been discussed, and the research is mixed. 

Depression and marijuana use often exist side-by-side in patients, but teasing apart their relationship with one another is a chicken-and-egg problem researchers have yet to solve.

Marijuana and Depression

A February 2015 study by researchers at the University of Buffalo's Research Institute on Addictions found that chemical compounds in the brain known as endocannabinoids, which are linked to feelings of overall well-being, activate the same receptors as many of the active compounds in marijuana.

In testing on rats, the researchers found that the production of endocannabinoids was lower in states of chronic stress than under normal conditions. They concluded that the chemicals in cannabis may be a useful treatment in restoring normal endocannabinoid function and alleviating symptoms of depression.


Although there is some evidence that marijuana may have antidepressant properties, many argue there are also some important drawbacks to its usage.

There is a well-known phenomenon called "amotivational syndrome," in which chronic cannabis users become apathetic, socially withdrawn, and perform at a level of everyday functioning well below their capacity prior to their marijuana use.

There are other studies that indicate that marijuana is associated with an increased risk of depression.

Root Causes

Most health care researchers and practitioners accept the theory that genetic, environmental, or other factors are the root cause of depression. Some believe that these same causes can lead to marijuana use. Participants in a 1997 pilot study reported that one of the reasons they continued to smoke marijuana was that they felt it relieved their symptoms of depression and anxiety.

Some research indicates that marijuana users (especially regular or heavy users) are more likely to be diagnosed with depression than those who don't use the drug.

But research has failed to conclude that there is a causation relationship at play: it is not clear that depression directly results from marijuana use.

In some patients with a predisposition to other mental illnesses, such as schizophrenia, and bipolar disorder, marijuana use may serve as a trigger for the disease's expression. There also is some evidence that teenagers who attempt suicide may be more likely to have used marijuana than those who have not made an attempt.

As with marijuana use and depression, more research is needed to better understand these associations. As states continue to pass medical marijuana laws and refine the criteria for eligibility, more research will likely go further toward exploring the relationship between depression and marijuana use.

If you or a loved one are struggling with depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area.

For more mental health resources, see our National Helpline Database.

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  1. University at Buffalo. RIA neuroscience study points to possible use of medical marijuana for depression. February 2015.

  2. Lac A, Luk JW. Testing the amotivational syndrome: marijuana use longitudinally predicts lower self-efficacy even after controlling for demographics, personality, and alcohol and cigarette use. Prev Sci. 2018;19(2):117-126. doi:10.1007/s11121-017-0811-3

  3. Gruber AJ, Pope HG, Oliva P. Very long-term users of marijuana in the United States: a pilot study. Subst Use Misuse. 1997;32(3):249-64. doi:10.3109/10826089709055849

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