When Your Antidepressant Makes You Tired

antidepressant fatigue

Verywell / JR Bee

Side effects from antidepressants are hard to avoid. Fatigue is one of them. This mostly is true of tricyclic antidepressants like Elavil (amitriptyline) and Tofranil (imipramine), which doctors don't often prescribe any more.

But even the newer classes of antidepressants—including selective serotonin reuptake inhibitors (SSRIs) such as Prozac (fluoxetine) and serotonin and norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta (duloxetine)—can lay you low.

Given that depression itself can make you feel exhausted, it can be frustrating to find that the medication you're taking to treat it isn't helping with your fatigue. If you're dealing with this particular problem, here are some ways you may be able to get the benefits of your medication without constantly feeling like you need a nap.

Why Antidepressants Cause Fatigue

Certain antidepressants work by acting on brain chemicals called neurotransmitters—in particular norepinephrine and serotonin—causing them to linger in the spaces between nerve cells where they carry out their job of regulating mood.

At the same time, though, these medications affect other neurotransmitters, including histamine and acetylcholine, sometimes leading to unpleasant side effects such as dry mouth, blurry vision, weight gain, and sedation. It's this last side effect that may be responsible for the fatigue you experience when you take an antidepressant.

What to Avoid

If you're truly fighting to keep your eyes open, there are some important things to avoid doing. Do not get behind the wheel of your car. Let someone else do the driving, call a car service or cab, or use public transportation until you've found a workaround for your fatigue.

Steer clear of alcohol and any medications that also tend to be sedating. The combo of either with your antidepressant could make your fatigue worse.

Strategies to Reduce Tiredness

You may be tempted to give in to exhaustion and set up camp on your couch, but there are other things you can do if your antidepressant is wiping you out. Here are some possibilities.


Make time to nap during the day. This doesn't mean you have to climb under the covers and snooze the afternoon away. According to the National Sleep Foundation, just 20 minutes of sleep is enough to leave most people feeling refreshed and energized. In fact, more shut-eye than that can make you even groggier.

Work Out

Get some exercise. It sounds counterintuitive—how could moving possibly be helpful when the last thing you feel like doing is moving? A 2008 study at the University of Georgia found that regular low-intensity exercise could reduce fatigue by as much as 65%, for example.

This was especially true of people in the study who did low-intensity exercise as opposed to moderate-intensity activity. That means that a leisurely walk could do more to perk you up than, say, a challenging stint on an exercise bike.

Take Medications at Night

Pop your pill at bedtime. Unless there's some reason your doctor would prefer you down your depression medication in the morning or during the day, taking it at night may help you fall asleep more easily so you get the rest you need to feel more alert during waking hours. 

Give It Time

Wait it out. For most people, the side effects of antidepressants wear off as their bodies become adjusted to the medication.

When to See a Doctor

If after several weeks you're still feeling zonked, you and your doctor may need to go back to the drawing board and try a different drug or supplement your medication with a second drug that's stimulating, such as Provigil (modafinil).

1 Source
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Puetz TW, Flowers SS, O'Connor PJ. A randomized controlled trial of the effect of aerobic exercise training on feelings of energy and fatigue in sedentary young adults with persistent fatigue. Psychother Psychosom. 2008;77(3):167-74. doi:10.1159/000116610

By Nancy Schimelpfening
Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.