OCD Treatment Herbal Remedies for OCD and Anxiety Disorders By Owen Kelly, PhD Owen Kelly, PhD Owen Kelly, PhD, is a clinical psychologist, professor, and author in Ontario, ON, who specializes in anxiety and mood disorders. Learn about our editorial process Updated on March 08, 2020 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Elena Klimenko, MD Medically reviewed by Elena Klimenko, MD Facebook LinkedIn Elena Klimenko, MD, is a board-certified doctor in internal medicine and licensed in medical acupuncture and homeopathy. Learn about our Medical Review Board Print Avalon_Studio / Getty Images Table of Contents View All Table of Contents Research Standards Alternative Medicine and Herbs Side Effects Other Therapies Alternative medicines such as herbal remedies have been growing in popularity especially as treatments for anxiety disorders such as obsessive-compulsive disorder (OCD). When you examine the science behind each treatment, it's important to take research quality and the consistency of research results in mind. It's also smart to consider potential side effects and safety concerns. Herbal Remedy Research Standards There are special considerations to take into account when looking at scientific studies that investigate the effectiveness of herbal remedies for OCD, anxiety disorders, or any other mental health condition. Sometimes, study results sound impressive because basic research standards were compromised. First, studies using herbs which are not in a standardized form may have varying activity levels of chemical components. Studies must take into account the accurate identity of the plant as well as whether the active constituents come from the leaf, root, seed, or stem of the plant. Studies evaluating the effectiveness of medications should also include a placebo treatment group that receives a “sugar pill” that is inactive and could not possibly account for any reduction in symptoms. By using a placebo treatment, it is possible to tell if the actual drug had an effect or not. Lastly, it is important that neither the researchers nor the study participants know who is receiving what treatment until the study is over to avoid bias. A medical study in which neither the patient nor the physicians know who is using the medication or supplement and who is receiving a placebo is called a double-blind study. Alternative Medicine and Herbs for OCD Nutritional supplements are available for OCD and anxiety. But you should inform yourself about the evidence-based benefits and potential side effects before you decide to take one. Currently, there is limited evidence that herbal remedies like those mentioned here are beneficial in reducing the severity of OCD symptoms. But research is ongoing. Most herbal remedies are available at drugstores without a prescription. However, it's important to talk to your doctor before taking any supplement. In addition to having side effects, many of these nutritional supplements can interfere (enhance or decrease) the actions of prescription medications. St. John’s Wort St. John’s Wort (Hypericum perforatum) is best know as an herbal anti-depressive, although its effectiveness in treating depression and other forms of mental illness is controversial. St. John’s Wort has been widely used (and in some cases, licensed) in Europe for decades to treat mood and anxiety disorders. An analysis has found that hypericum—the chemical that's thought to be the key ingredient in St. John’s Wort—appears to affect the serotonin system. Disruptions in the serotonin system are thought to be important in the development of symptoms of OCD. Given that antidepressant medications such as Paxil (paroxetine) and Anafranil (clomipramine) that target the serotonin system are also effective in treating OCD, it has been suggested that St. John’s Wort could be an alternative therapy for reducing OCD symptoms. But, the evidence that St. John’s Wort is an effective treatment for OCD is limited. A case study (one patient) suggested that St. John’s Wort was effective in reducing symptoms. A second study (12 people with OCD) found that it produced a significant reduction in symptoms that were similar to what would be expected with treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant medication. Neither study properly accounted for the placebo effect. In both cases, the people participating in the research studies were told upfront that they were going to be receiving St. John’s Wort in the hopes of reducing their OCD symptoms. Simply knowing that they were receiving a potentially beneficial treatment could have been enough to cause people to feel better. At least one randomized-controlled trial looked at whether St. John’s Wort was effective in reducing OCD symptoms. In the study, 60 people randomly received either St. John’s Wort or placebo. The reduction in symptoms among those who took St. John’s Wort was no different than it was in those who took a placebo. Results like this question the effectiveness of St. John's Wort as an OCD treatment. Milk Thistle Milk thistle (Silybum marianum) is an herbal remedy that has long been used in Iran. In 2010, a double-blind, placebo-controlled study compared the effects of milk thistle to the antidepressant Prozac (fluoxetine) in treating OCD (600 milligrams of milk thistle vs 30 milligrams of Prozac daily). It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. N-Acetylcysteine N-Acetylcysteine is an amino acid that moderates glutamine in the brain. N-acetylcysteine helps produce glutathione, an important antioxidant. A single study of a single person found that N-acetylcysteine improved the actions of the SSRI Luvox (fluvoxamine), resulting in a significant decrease in OCD symptoms. 5-HTP and Inositol Since the dysregulation of serotonergic and glutamatergic pathways in the brain appears to occur with OCD, other herbs that work in this pathway have also been considered for their possible benefits. Some of these include 5-hydroxytryptophan (5-HTP) and inositol. Kava (Piper Methysticum) Kava is an herbal medication found in clinical trials to reduce anxiety, nervous tension, restlessness, and mild depression. It has been used for hundreds of years in Polynesia, the Micronesia Islands, and Hawaii. The key constituent in Kava is kavalactone, which stimulates production of both serotonin and gamma amino butyric acid (GABA) in the body which produce a calming effect to the body. It's best to take Kava from a water-based extract at less than 250 mgs per day. Kava is not recommended during lactation or pregnancy. Kava has been banned or restricted in some countries after suggestions that it may cause liver problems in some individuals. Side Effects Although many consumers believe that herbals are safer and have fewer adverse effects than prescription medications, treatments like St. John’s Wort are not regulated as closely as conventional medications are and they may cause unpleasant or even dangerous side effects in some people. Herbal treatments can also interfere with prescription medications that you may already be taking. For example, if you are currently taking an SSRI to treat OCD, it is essential that you consult your treating physician before taking St. John’s Wort as it could affect your body’s ability to metabolize it. This could lead to a problem known as serotonin syndrome. Other Complementary Therapies Don't forget that there are other alternatives for treating the symtoms of OCD. Beyond supplements, lifestyle interventions such as mindfulness meditation, acupuncture, and yoga may be effective as well. Unfortunately, there have been few clinical trials looking at these interventions for people with OCD and those that have been done are of fairly poor quality. Yet, unlike prescription drugs and herbal medications, lifestyle interventions rarely have significant side effects and may also help reduce stress. The Best Online Therapy Programs We've tried, tested and written unbiased reviews of the best online therapy programs including Talkspace, Betterhelp, and Regain. 8 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. National Institute on Aging. Placebos in Clinical Trials. Cui YH, Zheng Y. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults. 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Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(4):887-895. doi:10.1016/j.pnpbp.2011.02.011 National Center for Complementary and Integrative Health. Kava. National Center for Complementary and Integrative Health. St. John's Wort. By Owen Kelly, PhD Owen Kelly, PhD, is a clinical psychologist, professor, and author in Ontario, ON, who specializes in anxiety and mood disorders. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Speak to a Therapist for OCD Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.