How SSRIs Are Used to Treat Social Anxiety Disorder

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Selective serotonin reuptake inhibitors (SSRIs) are usually the first choice of medication for treating social anxiety disorder (SAD). SSRIs affect your brain chemistry by slowing re-absorption of the neurotransmitter serotonin, a chemical that we think helps to regulate mood and anxiety.


There are several SSRIs that may be recommended in treating SAD including the following. Each medication is listed by the brand name followed by the generic name in parentheses:

Three SSRIs, Paxil, Zoloft, and Luvox CR have been approved by the FDA for treating social anxiety disorder. All three medications have been shown in clinical studies to offer improvement of symptoms.

Paxil was the first SSRI to receive FDA approval and is still often prescribed. However, the medication that works for one person doesn't always work for another. So, your doctor will work with you to find the right prescription for you.


Your doctor will give you specific instructions on how to take your medication. It is important that you follow these directions. Generally, you will take an SSRI once a day, usually in the morning. Your doctor will usually prescribe a low dose at first, which will be increased gradually.

The dose that you require does not necessarily relate to the severity of your symptoms. Sometimes it is simply a reflection of your unique metabolism. It may take several weeks for you to notice an improvement in your symptoms.

Side Effects

SSRIs are generally the preferred medication for SAD because the side effects tend to be well-tolerated. However, there are several possible side effects. Here's an overview of what you could experience.

  • Anxiety-like symptoms: irritability, nervousness, shaky hands, sweating
  • Eating problems: weight gain or loss, loss of appetite
  • Physical ailments: skin rashes, dry mouth, headaches, nausea, dizziness
  • Sexual dysfunction: decreased sex drive, delayed or absent orgasm, erectile dysfunction
  • Sleep problems: drowsiness, fatigue or insomnia

If you have great difficulty with side effects, your doctor may decide to prescribe a different SSRI. In general, lower initial doses that are gradually increased reduce the chance that you will have bad side effects.


SSRIs should never be taken at the same time as monoamine oxidase inhibitors (MAOIs). The results of such a combination can be fatal. In addition, never start taking one of these medications within weeks of stopping the other.

Although rare, it is possible during the initial phase of treatment for symptoms to worsen rather than improve. It is important to monitor symptoms during this time and report any negative changes to your doctor.

In 2004, the FDA released an advisory concerning SSRIs and risk of suicidal thoughts and behaviors, particularly in children and adolescents. In addition to the FDA advisory on suicidal thoughts, there has also been an advisory released regarding the use of triptans for migraine headaches in combination with SSRIs.

In combination, there is a risk of serotonin syndrome, a potentially life-threatening condition. In general, it is important to inform your doctor of all medications, both prescription and nonprescription, that you are already taking.

If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.

For more mental health resources, see our National Helpline Database.

Stopping Treatment

SSRIs should always be discontinued under the supervision of a medical professional. Abruptly stopping these medications can result in a relapse of anxiety symptoms.

You also can experience serotonin withdrawal symptoms, including trouble with coordination, tingly sensations, vivid dreams, flu-like symptoms, anxiety, and depressed mood. To avoid these serotonin withdrawal symptoms and the possibility of relapse, SSRIs should always be gradually tapered off.

4 Sources
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Ferguson JM. SSRI Antidepressant Medications: Adverse Effects and Tolerability. Prim Care Companion J Clin Psychiatry. 2001;3(1):22-27. doi:10.4088/pcc.v03n0105

  2. Bartlett D. Drug-Induced Serotonin Syndrome. Crit Care Nurse. 2017;37(1):49-54. doi:10.4037/ccn2017169

  3. Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018;75(5):566-572. doi:10.1001/jamaneurol.2017.5144

  4. Gabriel M, Sharma V. Antidepressant discontinuation syndrome. CMAJ. 2017;189(21):E747. doi:10.1503/cmaj.160991

Additional Reading
  • Bezchlibnyk-Butler KZ, Jeffries, JJ, eds. Clinical Handbook of Psychotropic Drugs. Toronto, Canada: Hogrefe & Huber; 2003.
  • U.S. Food and Drug Administration. FDA. Antidepressant Use in Children, Adolescents, and Adults. 

By Arlin Cuncic, MA
Arlin Cuncic, MA, is the author of "Therapy in Focus: What to Expect from CBT for Social Anxiety Disorder" and "7 Weeks to Reduce Anxiety." She has a Master's degree in psychology.