Addiction Nicotine Use How to Quit Smoking Using Chantix to Quit Smoking By Terry Martin Terry Martin Facebook Twitter Terry Martin quit smoking after 26 years and is now an advocate for those seeking freedom from nicotine addiction. Learn about our editorial process Updated on July 05, 2020 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Armeen Poor, MD Medically reviewed by Armeen Poor, MD Armeen Poor, MD, is a board-certified pulmonologist and intensivist. He specializes in pulmonary health, critical care, and sleep medicine. Learn about our Medical Review Board Print Verywell / Gary Ferster Have you been thinking about trying Chantix to quit smoking? Chantix (varenicline tartrate) is a non-nicotine prescription medicine that was developed by Pfizer, Inc. specifically to help people quit smoking. Chantix works on two levels. First, it partially activates sites in the brain, known as nicotinic acetylcholine receptors, that are affected by nicotine. This gives new ex-smokers mild nicotine-like effects and eases symptoms of nicotine withdrawal. Second, Chantix has the unique ability to stop nicotine from attaching to those nicotine receptors if you do smoke while using it. How Nicotine Affects Brain Chemistry Nicotine gives you an almost immediate kick of euphoria (a feeling or state of intense excitement and happiness) that's the result of rapidly changing brain chemistry. It starts within seven seconds of the first puff on a cigarette. The nicotine molecule is very similar in shape to a neurotransmitter (a chemical messenger that transports and maintains signals between nerve cells and other body cells) called acetylcholine, which affects many bodily functions, including breathing, heart rate, learning, and memory. Acetylcholine also affects other neurotransmitters that have an influence over appetite, mood, and memory. In the brain, nicotine binds to nerve cell receptor sites in places where acetylcholine would, creating the same effects. Once it's attached, a release of dopamine is triggered. Dopamine is the neurotransmitter thought to be responsible for reinforcing the pleasure/reward associations people have with smoking. It is this chemical process that is thought to be responsible for addiction. Other addictive drugs such as cocaine, amphetamines, and opioids also trigger the release of dopamine. The acute effects of nicotine wear off within minutes, so people continue dosing themselves frequently throughout the day to maintain the effects of nicotine and to prevent withdrawal symptoms. How Chantix Affects Nicotinic Receptors When Chantix is introduced into the brain, it targets alpha4beta2 nicotinic receptors, which are a specific type of nicotinic receptor. It docks with these receptors, triggering a release of dopamine in the same way nicotine would, though not quite as much. For ex-smokers, the effect is equal to a low to medium dose of nicotine that lasts until the drug wears off, which is several hours. In this way, Chantix helps to relieve symptoms of nicotine withdrawal that people experience when they quit smoking. The added bonus is that while Chantix is docked at these receptor sites, nicotine cannot be. If you smoke a cigarette while you have Chantix in your system, the cigarette will not offer its usual dopamine boost. Smoking will be a flat and dull experience, which may make quitting easier to achieve. Safety Concerns and Side Effects of Chantix Research on Chantix's Effectiveness Six clinical trials involving 3,659 chronic cigarette smokers tested the effectiveness of Chantix as a therapy for smoking cessation. The trials showed that Chantix was more effective than a placebo to help people quit smoking. In two trials, people using Chantix therapy were more successful at quitting smoking (22% succeeded) than those using Zyban (bupropion hydrochloride) as a quit smoking aid (16% succeeded). For those taking a placebo, success at the one-year mark was approximately 8%. In another study, researchers looked at 1,086 people who quit smoking using Chantix, the nicotine patch, or the patch and nicotine lozenges used in combination. The results indicated that the three methods were similar in success rates at both six months and one year. At six months, 23% of participants who used the patch were still smoke-free, compared to 24% of those using Chantix, and 27% of people who used a combination of the patch and lozenges. At one year, the success rate was 21% for the patch, 19% for Chantix, and 20% for the combination method. Other research has also suggested that a combination of Chantix and the nicotine patch is more effective than using Chantix alone. However, more studies are needed. Even Small Success Is a Victory While the success rate may not seem like great odds, keep in mind the sheer number of people who are addicted to nicotine and dying because of it today. Globally, smoking-related diseases cause more than 8 million deaths every year. Products and Aids for Quitting Smoking Put another way, tobacco claims a human life every five seconds somewhere in the world. A drug that has the potential to help about 25% of people using it to quit smoking is worth considering. It's also important to have quit aid choices available, because what works for one might not work for the next person. Greater choice ultimately equals a greater chance for success. A Word From Verywell In the years since Chantix became available, a number of serious health concerns associated with its use have been identified, including changes in behavior, hostility, agitation, depressed mood, and suicidal thoughts or actions. For some people, these symptoms begin when taking the drug. Others develop them after several weeks or even after stopping Chantix. As with any drug, it's important to tell you doctor about any history of depression or other mental health problem before taking Chantix. Together, you can decide whether it might be a good quit smoking aid for you. If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911. For more mental health resources, see our National Helpline Database. 6 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Naqvi NH, Bechara A. The airway sensory impact of nicotine contributes to the conditioned reinforcing effects of individual puffs from cigarettes. Pharmacol Biochem Behav. 2005;81(4):821-9. doi:10.1016/j.pbb.2005.06.005 U.S. Food and Drug Administration. ScienceDaily. FDA approves novel medication for smoking cessation. PharmaTimes. Chantix better than Zyban? Baker TB, Piper ME, Stein JH, et al. The effects of the nicotine patch vs. varenicline vs. combination nicotine replacement therapy on smoking cessation at 26 weeks: A randomized controlled trial. JAMA. 2016;315(4):371-379. doi:10.1001/jama.2015.19284 World Health Organization. Tobacco. Pfizer. About Chantix. Additional Reading Koegelenberg CF, Noor F, Bateman ED, et al. Efficacy of varenicline combined with nicotine replacement therapy vs, varenicline alone for smoking cessation: A randomized clinical trial. JAMA. 2014;312(2):155-61. doi:10.1001/jama.2014.7195 By Terry Martin Terry Martin quit smoking after 26 years and is now an advocate for those seeking freedom from nicotine addiction. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Get Treatment for Addiction Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.