Addiction Drug Use Hallucinogens How Long Does LSD (Acid) Stay in Your System? LSD (Acid) in Your Blood, Urine, & Hair By Buddy T Buddy T Facebook Twitter Buddy T is an anonymous writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. Learn about our editorial process Updated on December 10, 2019 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Steven Gans, MD Medically reviewed by Steven Gans, MD Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Print Verywell / Cindy Chung Table of Contents View All Table of Contents Effects Duration Detection Times Elimination Symptoms of Overdose Getting Help LSD (lysergic acid diethylamide), often called acid, is an illicit hallucinogenic drug that affects your perceptions for several hours and is detectable on drug screening tests. The drug can be detected by urine, blood, and hair tests, but does not show up on standard saliva tests. LSD is classified as a Schedule I drug, meaning there is no currently accepted medical use. While LSD is not considered addictive, it can have intense effects and a potential for long-term physical and mental consequences. Tolerance to the drug builds quickly, which means that it takes increasingly higher doses to experience the same effects. Verywell / Cindy Chung How Long Does It Take to Feel Effects? LSD is usually swallowed as a capsule or liquid or absorbed in your mouth on a paper square. Users feel the effects of LSD 20 to 90 minutes after taking a dose, peaking at two to four hours, and diminishing over six to eight hours. In addition to sensory and mood effects, LSD use may also result in: DelusionsDizzinessDry mouthElevated body temperatureHallucinationsIncreased blood pressureIncreased heart rateLoss of appetiteNauseaNumbnessSleepinessSweatingTremorsWeakness While on an LSD acid trip, people can have rapid emotional shifts, intensified and distorted sensory experiences, and changes in the perception of time. If a large dose of LSD is taken, it can produce some very unpleasant effects, sometimes called a "bad trip." But some people can experience a bad trip no matter how much they consumed. LSD can also produce delusions and visual hallucinations, which can cause some people to panic. People can also experience severe, terrifying thoughts and feelings of despair, fear of losing control, or fear of insanity and death. One long-term but the rare danger of LSD use is a condition called hallucinogen persisting perceptual disorder (HPPD) in which flashbacks persist and produce distress or impairment for the user in social or occupational functioning. What to Know About LSD Use How Long Does LSD Last? The half-life of LSD is around 5.1 hours. The effects can last up to 12 hours. Research has found that peak levels following a single-dose occur at a median of 1.5 hours after administration. After peaking, drug levels decline and reach half of the peak levels at approximately 3.6 hours after administration but the effects of the drug can last for up to 12 hours. Once orally ingested, the substance is quickly absorbed through the gastrointestinal tract and mucous membranes. The drug reaches the bloodstream and organs quickly, about 10 to 15 minutes after being ingested. The drug is primarily processed by the liver, where it is metabolized into a number of other inactive metabolites. Within 24 hours, almost all the drug has been metabolized and excreted. Approximately 13% of the drug is eliminated as a metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD). Research suggests that this byproduct is present in urine samples at concentration levels 16 to 43 times higher than LSD. Researchers have attempted to develop different methods for detecting LSD, but the fact that the drug is unstable, broken down so quickly, and usually taken in relatively small amount presents challenges. Urine LSD can generally be detected in urine tests within eight hours of use and up to two to four days after use. Blood In one study, researchers found that LSD was detectable in blood samples taken 16 hours after participants had been given 200mcg of LSD. For those given a smaller dose of 100mcg, researchers were able to detect the substance in blood tests 8 hours after administration. Because levels decline steadily over time, the ability to detect the substance dropped considerably after the 16-hour mark. Hair LSD, like many other drugs, can be detected with a hair follicle drug test for up to 90 days. However, the use of hair testing is relatively rare. Because the drug is often taken at such low doses, it can be very difficult to detect in both research and forensic settings. While hair tests may occasionally be used to check for LSD, they tend to be costly and their results may be unreliable. False Positive Testing There are some medications that may cause false-positive urine drug screens for LSD, including: AmbroxolAmitril (amitriptyline)Buspar (buspirone)Cardizem (diltiazem)FentanylProzac (fluoxetine)Risperdal (risperidone)Ritalin (methylphenidate)Trandate (labetalol)Verelan (verapamil)Wellbutrin (bupropion)Zoloft (sertraline) As a result, positive LSD results are critically evaluated and initial positive results must be confirmed by a second independent testing technique. Always disclose any prescription or over-the-counter medications you are taking to the lab so clinicians can accurately interpret your drug screen results. What Does It Feel Like to Use LSD? Factors That Affect Detection Time There are a number of different factors that can affect how long LSD can be detected in the body. How soon LSD is eliminated depends on your metabolism and factors such as your weight, whether you are well-hydrated, and how healthy all of your bodily systems are. Keep in mind that if you have any other drugs in your system, they may be detectable on drug screens for longer than LSD and might influence how long LSD stays in your system. You cannot be assured of the purity of an illegally manufactured drug and there may be other detectable substances in LSD doses. With LSD, timing is a key factor that influences whether the drug will be detectable by screening tests. After 24 hours, the drug will no longer be detectable in blood tests. After 72 hours, the drug is much more difficult to detect on urine tests. Some other factors that can influence detections times for LSD include age, liver function and metabolism. Here is an overview of the impact they have on detection. Age Younger people metabolize LSD faster than those over the age of 65. This is due to the fact that younger people typically have faster metabolisms and better liver function than older adults. Liver Function The liver plays a key role in the metabolism of LSD, so the drug may be detectable longer in those with reduced or impaired liver function. Metabolism As with other substances, overall metabolism plays a part in determining how quickly LSD is cleared from the body. People with faster metabolisms may process the drug much more quickly than those with slower metabolisms. How to Get LSD Out of Your System If you need to get LSD out of your system quickly, there are some steps that you can take to possibly speed up the process. Discontinue use: With LSD, timing is the critical factor. It is much harder to detect the drug after 24 hours from your last use on blood tests. So, the sooner you stop using, the better.Exercise: Physical activity may accelerate metabolism.Stay hydrated: As with other drugs, hydration levels can have an impact on how quickly LSD is metabolized. Because LSD and its metabolites are excreted through urine, drink plenty of fluids to flush the drug out. Symptoms of Overdose The use of LSD at high doses and in combination with some other substances, including some antidepressants, can lead to a potentially dangerous phenomenon known as serotonin syndrome. This condition is caused when there is too much serotonin in the body, resulting in symptoms including confusion, muscle spasms, tremors, rapid heartbeat, and nausea. While there is no known lethal dose of LSD, taking too much can result in a terrifying experience that is commonly known as a "bad trip." This experience is dangerous because it may result in hallucinations, self-harm, risky behaviors, or suicide. Self-destructive behaviors like running away from home, cutting, or talking about suicide need to be addressed, whether or not bullying is the root cause. Potential symptoms that may occur after a "bad trip" can include: AccidentsDelusionsHallucinationsMood swingsPanic ParanoiaSelf-injurySevere anxietySuicide If you suspect that someone is having an adverse reaction to LSD use, contact emergency services right away. Stay with the person and try to keep them calm until help arrives. What Happens During a Bad Trip? Getting Help LSD affects your mind and body significantly for at least 12 hours after a dose. You cannot be assured of the dosage and purity of an illegally manufactured drug, which can influence how long you feel the effects and how long it remains in your system. LSD can affect your ability to function normally at work, at home, and at school. If you feel like you need help, talk to your doctor about your options. Treatment approaches may include outpatient or inpatient rehab that focuses on individual counseling, group therapy, and family therapy. There are no FDA-approved drugs used in the treatment of LSD use. However, your doctor may prescribe medications to help treat symptoms of other psychiatric conditions including depression and anxiety. If you are concerned about your LSD use, you can also contact the SAMHSA National Helpline at 1-800-662-4357 or utilize their online treatment locator to find treatment resources near you. For more mental health resources, see our National Helpline Database. How to Find the Right Drug Treatment Program 10 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Hwang KAJ, Saadabadi A. Lysergic Acid Diethylamide (LSD). StatPearls. March 2019. https://www.ncbi.nlm.nih.gov/books/NBK482407/. Preller KH, Razi A, Zeidman P, Stämpfli P, Friston KJ, Vollenweider FX. Effective connectivity changes in LSD-induced altered states of consciousness in humans. Proc Natl Acad Sci U S A. 2019;116(7):2743–2748. doi:10.1073/pnas.1815129116 Dolder PC, Schmid Y, Steuer AE, et al. Pharmacokinetics and pharmacodynamics of lysergic acid diethylamide in healthy subjects. Clin Pharmacokinet. 2017;56(10):1219-1230. doi:10.1007/s40262-017-0513-9 Klette KL, Anderson CJ, Poch GK, Nimrod AC, Elsohly MA. Metabolism of iysergic acid diethylamide (LSD) to 2-oxo-3-hydroxy LSD (O-H-LSD) in human liver microsomes and cryopreserved human hepatocytes. J Anal Toxicol. 2000;24(7):550-6. doi:10.1093/jat/24.7.550 Richeval C, Allorge D, Vanhoye X, Gaulier JM. LSD Detection and interpretation in hair. Curr Pharm Des. 2017;23(36):5496-5501. doi:10.2174/1381612823666170622102943 Saitman A, Park HD, Fitzgerald RL. False-positive interferences of common urine drug screen immunoassays: A review. J Anal Toxicol. 2014;38(7):387-396. doi:10.1093/jat/bku075 Röhrich J, Zörntlein S, Lotz J, Becker J, Kern T, Rittner C. False-positive LSD testing in urine samples from intensive care patients. J Anal Toxicol. 1998;22(5):393-5. doi:10.1093/jat/22.5.393 Gagajewski A, Davis GK, Kloss J, Poch GK, Anderson CJ, Apple FS. False-positive lysergic acid diethylamide immunoassay screen associated with fentanyl medication. Clin Chem. 2002;48(1):205-6. Last J. LSD Does Not Stay in Your Body Forever. The Vaults of Erowid website. May 2006. Nichols DE, Grob CS. Is LSD toxic? Forensic Sci Int. 2018;284:141-145. doi:10.1016/j.forsciint.2018.01.006 Additional Reading Hermle L, Simon M, Ruchsow M, Geppert M. Hallucinogen-persisting perception disorder. Ther Adv Psychopharmacol. 2012;2(5):199–205. doi:10.1177/2045125312451270 NIH MedlinePlus. Toxicology Screen: MedlinePlus Medical Encyclopedia; 2019. By Buddy T Buddy T is an anonymous writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. 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