How Long Does Norco Stay in Your System?

Avoid Risks of Interactions and Overdose

Norco 7.5 Label
How Long Does Norco Stay in the Body?. Watson

Norco is a combination product containing acetaminophen and hydrocodone that is prescribed for moderate to severe pain. There is a risk of drug interactions and overdoses due to both of the drugs in the combination. By understanding how long they stay in your system you may be able to prevent these reactions.

Risks With Norco in Your System

Hydrocodone is an opiate narcotic and it has the risk of dangerous interactions with alcohol and other medications.

These risks include breathing problems, sedation, and coma. It is critical that you don't use alcohol or street drugs while you are taking Norco.

Discuss all of your prescription, non-prescription, and over-the-counter medications, supplements, and vitamins with your doctor or pharmacist. While many drugs interact with hydrocodone, the highest risks are with benzodiazepines (Xanax, Librium, Klonopin, Diastat, Valium, Ativan, Restoril, Halcion and others), muscle relaxants, sedatives, sleeping pills, tranquilizers, and medicines for mental illness or nausea.

You may not realize the amount of risk that comes from the acetaminophen in Norco, since that is found in Tylenol and other over-the-counter remedies. That's a big part of the problem, as people are often taking more than one medication that has acetaminophen. If you exceed 4000 milligrams per day, you risk irreversible liver damage that could be fatal.

Many accidental deaths have occurred with combination products, and so the amount of acetaminophen is now limited to 325 mg. per dose of any combination product.

How Long Does Norco Stay in Your System?

The acetaminophen in Norco has a half-life in the blood of 1.25 to 3 hours, depending on whether a person has poor liver function.

Most of it has passed out through the urine in 24 hours.

The half-life of hydrocodone is about 4 hours, which it the time in which half of it is no longer acting in your system. After five or six half-lives, a drug has been mostly eliminated from your system. Hydrocodone can be detected in the urine for up to 3 days. If you take a urine drug screen while you are taking Norco, it is likely to test positive for opiates. Be sure to disclose your medications to the testing laboratory so they can interpret your test accurately.

Another risk of pain relievers that contain hydrocodone is that you may have withdrawal symptoms if you have been taking them for several weeks and then stop. Work with your doctor to avoid this problem.

Signs of a Norco Overdose

Knowing how long Norco remains in the system and help prevent an accidental overdose by taking too much of the medication too soon. 

Here are some of the signs and symptoms of a Norco overdose:

Call 9-1-1 immediately if you suspect someone has taken an overdose of Norco. First responders may be able to revive the person by administering Narcan.


Hydrocodone and acetaminophen overdose. MedlinePlus NIH.

Hydrocodone Combination Products. MedlinePlus NIH.

Opiates. Mayo Medical Laboratories.