How Long Does Versed (Midazolam) Stay in Your System?

Versed in Your Blood & Urine

Midazolam package
Roche
In This Article

Versed (midazolam) is a drug usually used for pre-anesthesia sedation and for procedural sedation for children and adults. It is often used for uncomfortable procedures such as colonoscopies because it produces memory impairment.

Versed is in a class of drugs called benzodiazepines, which are central nervous system depressants and Schedule IV controlled substances.

When combined with alcohol or other depressants, or when taken in large dosages, Versed can cause a loss of consciousness and respiratory failure, so it's important to know how long it remains in your system to avoid dangerous drug interactions and potential overdoses.

How Long Does Versed Stay in Your System?

Urine: Up to two days

How Long Does It Take to Feel Effects?

There are several ways Versed can be administered, but it must always be done where there is immediate access to monitoring for breathing and heart function due to associated risks. It is administered by medical professionals in a hospital, day surgery clinic, or doctor's office.

It can be given as an injection, by tablet, or in a syrup. How Versed is taken will determine how fast it takes effect. In adults, an injection or IV takes effect in about 15 minutes with maximum effect in 30 to 60 minutes, lasting around 2 hours (though recovery can take up to 6 hours in some cases). As a syrup, the effects of Versed in children are seen in 10 minutes and last for about 45 minutes.

The cognitive effects of Versed can last longer, and you should plan your schedule so you won't be doing any tasks that require coordination and concentration.

You won't be allowed to drive yourself home after Versed is administered for a procedure, and you'll need to take the day off of work.

How Long Does Versed Last?

The half-life of Versed, or how long it takes for half of the drug to leave your system, is roughly 1.8 to 6.4 hours—or an average of about 3 hours.

Midazolam, the active ingredient in Versed, is metabolized by the liver and gut before it is eliminated in the urine. Versed (midazolam) can be detected in blood and urine tests for prescription drugs and has a urine detection window of 1 to 2 days.

If you will be taking any such test, be sure to inform the testing laboratory that you have had it administered by your doctor so the test can be interpreted correctly.

Factors That Affect Detection Time

How long it takes your body to fully eliminate the drug depends on a number of factors, including age, liver function, and any other medications that were administered or you have been taking.

  • Age: Children, newborns, and geriatric patients can take longer than older children and healthy adults to metabolize and eliminate the drug.
  • Liver and kidney function: People with liver or renal impairment have been found to have longer elimination half-lives.

How to Get Versed Out of Your System

The only way to get Versed out of your system is to stop taking it and allow your body time to process and eliminate it.

Symptoms of Overdose

Because Versed is a central nervous system depressant, there is a risk of death if an overdose occurs. Symptoms of an overdose of Versed include the following:

  • Coma
  • Confusion
  • Difficulty with balance and movement
  • Drowsiness
  • Loss of consciousness for an extended period of time
  • Possible death
  • Slowed breathing
  • Slowed heartbeat
  • Slowed reflexes

If you suspect a Versed overdose, call 911 immediately or call Poison Control at 1-800-222-1222).

Getting Help

If you experience any of the following serious side effects that you think may be related to Versed, contact your doctor.

  • Aggression
  • Agitation
  • Ongoing nausea and vomiting
  • Persistent rash
  • Restlessness
  • Slowed or irregular heartbeat
  • Stiffening and jerking of the arms and legs
  • Uncontrollable shaking of a body part

Dangerous Interactions

It is important to not drink alcohol or take any other medications that depress your nervous system for 24 hours after you have been administered Versed. Be sure to tell your doctor about all the medications, vitamins, supplements, and herbal products that you're taking prior to your surgery or procedure, as some of these substances can cause serious interactions, including:

  • Anticonvulsants
  • Antidepressants
  • Antihistamines
  • Certain antibiotics
  • Certain antifungals
  • Certain calcium channel blockers
  • Grapefruit
  • Narcotic cough medicines
  • Other sedatives
  • St. John's Wort

A Word From Verywell

If you are concerned about how long Versed will stay in your system after being administered, talk to your doctor to find out exactly what to expect. Any indication of how long a drug will stay in your system is only a best estimate, and you should always plan accordingly.

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Article Sources
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