How Long Does Versed (Midazolam) Stay in Your System?

Versed in Your Blood & Urine

Midazolam package
Roche
In This Article

Versed (midazolam) is a drug usually used for pre-anesthesia sedation and for procedural sedation for children and adults. It is often used for uncomfortable procedures such as colonoscopies because it produces memory loss.

Versed is in a class of drugs called benzodiazepines, which are central nervous system depressants and Schedule IV controlled substances. When combined with alcohol or other depressants, or when taken in large dosages, Versed can cause a loss of consciousness and respiratory failure, so it's important to know how long it remains in your system to avoid dangerous drug interactions and potential overdoses.

How Long Does Versed Stay in Your System?

Urine: Up to two days

How Long Does It Take to Feel the Effects?

There are several ways Versed can be administered, but it must always be done where there is immediate access to monitoring for breathing and heart function due to associated risks. It is administered by medical professionals in a hospital, day surgery clinic, or doctor's office.

It can be given as an injection, by tablet, or in a syrup. How Versed is taken will determine how fast it takes effect. An injection or IV takes effect in five to 15 minutes with maximum effect in 15 to 60 minutes and lasts about 2 hours (though the range is anywhere between one and six hours). As a syrup, the effects of Versed in children are seen in 10 to 20 minutes.

The cognitive effects of Versed can last longer, and you should plan your schedule so you won't be doing any tasks that require coordination and concentration. You won't be allowed to drive yourself home after Versed is administered for a procedure, and you'll need to take the day off of work.

How Long Does Versed Last?

The half-life of Versed, or how long it takes for half of the drug to leave your system, is roughly 1.8 to 6.4 hours.

Midazolam, the active ingredient in Versed, is broken down into the liver to both active and inactive metabolites. It is mostly excreted in the urine but is also eliminated in the feces.

Versed (midazolam) can be detected in blood and urine tests for prescription drugs and has a urine detection window of 0.5 to 2 days.

If you will be taking any such test, be sure to inform the testing laboratory that you have had it administered by your doctor so the test can be interpreted correctly.

Factors That Affect Detection Time

How long it takes your body to fully eliminate the drug depends on many factors, including age, liver function, and any other medications that were administered or you have been taking.

  • Age: Children, newborns, and geriatric patients can take longer than healthy adults to metabolize and eliminate the drug.
  • Liver and kidney function: People with liver or renal impairment have been found to have longer elimination half-lives.

How to Get Versed Out of Your System

The only proven way to get Versed out of your system is to stop taking it and allow your body time to process and eliminate it.

Symptoms of Overdose

Because Versed is a central nervous system depressant, there is a risk of death if an overdose occurs. Symptoms of an overdose of Versed include the following:

  • Confusion
  • Drowsiness
  • Shallow respiration
  • Clammy skin
  • Dilated pupils
  • Fast or irregular heartbeat
  • Low blood pressure
  • Weak and rapid pulse
  • Confusion
  • Dizziness
  • Blurred vision
  • Depression
  • Coma
  • Possible death

If you suspect a Versed overdose, call 911 immediately or call the poison control center (1-800-222-1222).

If you experience any of the following serious side effects that you think may be related to Versed, contact your doctor.

  • Loss of memory during the time while the drug is being administered and the time immediately following
  • Slow breathing
  • Agitation, hyperactivity, or combativeness
  • Drowsiness
  • Increased coughing
  • Vomiting
  • Nausea
  • Rash
  • Problems with coordination and alertness

Dangerous Interactions

It is important to not drink alcohol or take any other medications that depress your nervous system for 24 hours after you have been administered Versed. Be sure to tell your doctor about all the medications, vitamins, supplements, and herbal products that you're taking prior to your surgery or procedure, as some of these substances can cause serious interactions, including:

  • Antidepressants
  • Certain antifungals
  • Certain antibiotics
  • Certain calcium channel blockers
  • Antihistamines
  • Cough medicine
  • Anticonvulsants
  • Other sedatives
  • St. John's Wort
  • Grapefruit

If you are concerned about how long Versed will stay in your system after being administered, talk to your doctor to find out exactly what to expect. Any indication of how long a drug will stay in your system is only a best estimate, and you should plan accordingly.

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Article Sources
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  1. Pfizer. Midazolam. November 2019.

  2. Substance Abuse and Mental Health Administration. Treatment improvement protocols. Appendix B. Urine collection and testing procedures and alternative methods for monitoring drug use. November 2019.

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