Addiction Drug Use Prescription Medications How Long Does Withdrawal From Hydrocodone Last? By Corinne O’Keefe Osborn Corinne O’Keefe Osborn LinkedIn Corinne Osborn is an award-winning health and wellness journalist with a background in substance abuse, sexual health, and psychology. Learn about our editorial process Updated on September 30, 2021 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by John C. Umhau, MD, MPH, CPE Medically reviewed by John C. Umhau, MD, MPH, CPE John C. Umhau, MD, MPH, CPE is board-certified in addiction medicine and preventative medicine. He is the medical director at Alcohol Recovery Medicine. For over 20 years Dr. Umhau was a senior clinical investigator at the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH). Learn about our Medical Review Board Print Table of Contents View All Table of Contents Overview Signs and Symptoms Coping and Relief Warnings Long-Term Treatment Resources Hydrocodone is a semi-synthetic opioid that works like codeine to relieve moderate pain. It is often prescribed in combination with other compounds in products like Vicodin or Lortab, which contain hydrocodone and acetaminophen. It is the most widely available opioid in the United States, which means that it is inexpensive and easy to come by. Many victims of the current opioid epidemic got their start with hydrocodone. Hydrocodone prescriptions have decreased in recent years, from 136.7 million prescriptions in 2013 to 83.6 million in 2017, but it is still the most commonly prescribed opioid in the United States. It is also one of the most widely abused prescription pain killers. Illustration by Cindy Chung, Verywell Overview Data from 2017 shows that roughly 6.3 million people age 12 or older had misused hydrocodone in the past year in the United States—amazingly, that is 2.3 percent of the population. Most of these people acquired the drug from someone they trusted, such as a doctor or family member. Unfortunately, hydrocodone misuse can quickly develop to dependence and addiction. Anyone who is physically dependent on opioids will experience withdrawal if they abruptly discontinue their dose. Symptoms can range from mild to severe, depending on how much you’ve been taking and for how long. If you are currently taking a high dose of hydrocodone, or a mix of hydrocodone and other opioids, then suddenly quitting "cold turkey" without tapering down is going to be really difficult. Even if you are on a lower, therapeutic dose of hydrocodone, the withdrawal is challenging—expect a feeling similar to having the flu (the severity will vary), plus psychological distress. Without treatment, most people experience chills, cramps, and diarrhea, along with nausea, sweating, and agitation. You might feel like your heart is pounding out of your chest or like you will never sleep again. Runny noses and teary eyes are common. Some people feel extremely anxious, and others feel intense despair and hopelessness. Opioid withdrawal isn’t easy, but it is quick. Symptoms typically subside within one week. Fortunately, there are medications that can get you through this period with minimal discomfort. Signs and Symptoms Like all forms of opioid withdrawal, hydrocodone withdrawal is not simple. Experiences vary from person to person, but typically include some combination of physical and psychological symptoms. Your personal experience will be shaped by a number of factors, including: your current dose and how often you take ithow long you have been using opioids or other drugswhether or not you are mixing hydrocodone with other drugs, such as heroin, Oxycontin, alcohol, or benzodiazepinesyour willingness to seek treatment and support your past experiences with substance abuseyour physical and mental health If you have been taking low doses of hydrocodone as directed by your doctor, then your withdrawal symptoms should be relatively mild. However, if you are a long-time poly-drug abuser, untreated withdrawal can be extremely uncomfortable. For most people, hydrocodone withdrawal symptoms start about eight to 24 hours after their last dose. Withdrawal will come on slower if you are also using extended release opioids, like methadone or Oxycontin. Common hydrocodone withdrawal symptoms include any of the following: Muscle, bone, and joint aches and painFlu-like feelingSweatingRunny noseHeadacheChillsNausea or vomitingCramping or diarrhea Insomnia or disturbed sleepTeary eyesTremorsAnxiety or restlessness GoosefleshHeart poundingAgitationSkin-crawling If you are looking for a better idea of how mild symptoms compare to intense symptoms, take a look at this opioid withdrawal scale. This is a tool that clinicians use to help them diagnose what stage of withdrawal their patients are in. For example, it shows that sweating can include anything from feeling flushed to sweat streaming down your face. Opioid withdrawal symptoms typically peak on the second or third day after your last dose, then start getting better. Most people feel better after five to seven days. Unfortunately, this isn’t always the end of it. Once acute withdrawal passes, some people experience something called protracted withdrawal, also known as post-acute-withdrawal syndrome (PAWS). Protracted withdrawal symptoms are much less severe and are mostly psychological in nature—meaning that you won’t be physically ill. Instead, you may experience waves of depression that come and go or bouts of insomnia. Not everyone experiences protracted withdrawal, but those who do can expect symptoms to appear on and off for around six months. Coping and Relief There are a number of steps you can take to ensure a smoother and less uncomfortable withdrawal experience. The best strategy for you will depend on your hydrocodone use patterns. Tapering If you have been using hydrocodone as directed for the treatment of pain, then your doctor can help you develop a tapering schedule. Tapering your medication means taking progressively smaller doses over a period of several weeks. By incrementally decreasing your dose, you give your body time to adjust. While you may experience some withdrawal symptoms each time the dose is reduced, they should be relatively mild. There is no standard tapering schedule, so it is important to work with your doctor to develop a schedule that fits your needs. As you reduce your dose, you may find that your pain returns. If so, talk to your doctor about alternatives. In addition to tapering your dose, there are other evidence-based treatments for opioid detox include medication-assisted treatment and symptom management. Medications Medications like methadone and buprenorphine (Suboxone) can help prevent the symptoms of withdrawal and make it easier to get clean. These drugs are made with long-acting opioids that prevent withdrawal without getting you high. Suboxone contains a mix of buprenorphine and naltrexone, an opioid antagonist. This means that it’s more or less impossible to abuse Suboxone to get high if injected. Suboxone can also prevent other opioids from getting you high, which reduces your chance of relapse. Clonidine and lofexidine (Lucemyra) are two more prescription drugs used to treat the symptoms of hydrocodone withdrawal. Clonodine and Lucemyra, similar medications originally designed to treat high blood pressure, are used to treat symptoms like sweating, chills, rapid heart rate, and anxiety. They can also help reduce drug cravings. Since they contain no opioids, any doctor can prescribe these medications. This makes them much easier to acquire than methadone and buprenorphine. Over-the-counter (OTC) medications that may make you more comfortable during withdrawal include: OTC pain relievers (Tylenol, Advil, Aleve)anti-diarrhea medications (Imodium, loperamide)antihistamines to help you sleep (Benadryl) anti-nausea medications (Pepto-Bismol, Kaopectate)nutritional supplements for anxiety (valerian root, chamomile) Herbal You may have heard about another herbal medication called kratom that people buy online. Some opioid users have had success using kratom to treat the symptoms of withdrawal, but there are a number of risks involved. Doctors are just beginning to learn how kratom works, but it is already clear that kratom is essentially just another natural opioid (like opium). In 2018, the FDA issued a warning against kratom, because they believe it has addictive and harmful properties. There have also been reports of contaminated batches making people ill. Warnings Although scientific evidence shows that medication-assisted treatment is the most effective way of treating opioid dependence, it is often surprisingly difficult to find. In fact, most people have trouble finding any substance use treatment at all. Lack of Treatment In 2017, it was estimated that 20.7 million people in the United States needed substance use treatment, but only 4 million received it. Only a small number of those who did receive help got it at a facility offering medication-assisted treatment. Treatment providers offering buprenorphine and methadone can definitely be difficult to find, but they do exist. It’s not an inability to find treatment that prevents people from getting help, rather it’s the belief that they don’t need help. Among the 20.7 million people who needed treatment for a substance use in 2017, only one million actually believed that they needed treatment. People typically underestimate the seriousness of their substance use disorder and overestimate their ability to “quit when they’re ready.” At-Home Withdrawal Today, it is possible to detox from hydrocodone at home without help. Unlike alcohol or benzodiazepine withdrawal, opioid withdrawal isn’t dangerous, though it can be extremely uncomfortable. Many people relapse within days or weeks of quitting. When you detox from hydrocodone, your tolerance level drops fast. If you were to relapse with your pre-detox dose, it could kill you. There are some people in the recovery community who believe that "abstinence-only" is the best way to go. They believe that medication-assisted treatment is just “replacing one drug with another.” Although this is technically true, it’s not so simple. Medications that prevent withdrawal have been shown to reduce relapse and give you the opportunity to participate in therapy. Without taking the time to address the issues that led to your substance abuse, your chance of relapse will remain high. Long-Term Treatment Your long-term treatment requirements will depend on the nature of your hydrocodone dependence. If you became dependent on opioids while taking them as prescribed by a doctor, you may not need any treatment after you get off the pills. If you are struggling with a substance use disorder, however, detox is only the first step on a long road. If your goal is long-term sobriety, then you will need to put a lot of effort into relapse prevention. If you have tried to quit opioids before, then you know how easy it is to relapse after detox. Research shows that the best way to prevent relapse is a combination of medication and psychotherapy. Preventing Relapse With Medication Your long-term treatment plan may involve a maintenance dose of methadone or buprenorphine or a medication called naltrexone (Vivitrol). Naltrexone is only useful after you detox, once your body is free of opioids. A Vivitrol injection taken once per month will prevent opioids from having an intoxicating effect. This discourages opioid use, because if you use, you will be wasting time and money for nothing. Naltrexone can also help ease opioid cravings and may help prevent a lethal overdose. Preventative Psychotherapy Medication paves the way for the second leg of long-term treatment, psychotherapy. During talk therapy, you will learn to identify the thoughts, feelings, and actions that trigger your cravings. You will also develop the skills you need to handle those triggers in a healthy way. Many people choose to continue taking their medication indefinitely, but you can also tapper off after a few months or years. Therapy can prepare you for that transition. There are many different types of treatment with varying levels of intensity. Places you can find help include: addiction treatment centersresidential programs community health clinicsyour primary care physiciana psychiatrist a therapist in private practicemethadone clinicsdoctors certified to prescribe buprenorphine (Suboxone) Resources If you or your loved one has a hydrocodone dependence, you will want to find a doctor or therapist who specializes in opioid use disorders. If you or a loved one are struggling with substance use or addiction, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area. For more mental health resources, see our National Helpline Database. Only certain doctors are allowed to prescribe buprenorphine (Suboxone). To find one in your area, check out this searchable directory. If you want to know more about Narcotics Anonymous (NA) take a look at their website. You can find a meeting near you with their searchable directory. A Word From Verywell Hydrocodone withdrawal is not easy, especially if you have been abusing opioids for a long time. Don’t be discouraged—there are ways to break the vicious cycle in which you feel trapped. Even if you have attempted detox several times before, you must keep up hope that the next one will work. If you want to get sober permanently, reach out for help. Find a treatment center offering evidence-based therapies like medication management. In addition, don’t let anyone shame you for taking a medication that treats your disease. Make the best decisions for you and your recovery. How Narcotic Anonymous Works 13 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. U.S. Drug Enforcement Administration. Hydrocodone. 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Am J Drug Alcohol Abuse. 2012;38(3):187–199. doi:10.3109/00952990.2011.653426 Gowing L, Ali R, White JM, Mbewe D. Buprenorphine for managing opioid withdrawal. Cochrane Database Syst Rev. 2017;2(2):CD002025. doi:10.1002/14651858.CD002025.pub5 Bryce C. Lofexidine (Lucemyra) for treatment of opioid withdrawal symptoms. Am Fam Physician. 2019;99(6):392–394. U.S. Food & Drug Administration. FDA and Kratom. Kadam M, Sinha A, Nimkar S, Matcheswalla Y, De Sousa A. A comparative study of factors associated with relapse in alcohol dependence and opioid dependence. Indian J Psychol Med. 2017;39(5):627–633. doi:10.4103/IJPSYM.IJPSYM_356_17 Sofuoglu M, DeVito EE, Carroll KM. Pharmacological and behavioral treatment of opioid use disorder. Psychiatr Res Clin Pract. 2019;1(1):4-15. doi:10.1176/appi.prcp.20180006 Jarvis BP, Holtyn AF, Subramaniam S, et al. Extended-release injectable naltrexone for opioid use disorder: a systematic review. Addiction. 2018;113(7):1188–1209. doi:10.1111/add.14180 McHugh RK, Hearon BA, Otto MW. Cognitive behavioral therapy for substance use disorders. Psychiatr Clin North Am. 2010;33(3):511–525. doi:10.1016/j.psc.2010.04.012 Additional Reading Amato L, Minozzi S, Davoli M, & Vecchi S. (2011). Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification. Cochrane Database of Systematic Reviews, 2011, Issue 9. DOI: 10.1002/14651858.CD005031.pub4 Drug Enforcement Administration. Hydrocodone. Food and Drug Administration. FDA Investigated Multistate Outbreak of Salmonella Infections Linked to Products Reported to Contain Kratom. National Institute on Drug Abuse. (2018). Misuse of Prescription Drugs: Research Report Series. 2018. Substance Abuse and Mental Health Services Administration. (2018). Key substance use and mental health indicators in the United States: Results from the 2017 National Survey on Drug Use and Health. U.S. Food and Drug Administration. Statement from FDA Commissioner Scott Gottlieb, M.D., on the agency’s scientific evidence on the presence of opioid compounds in kratom, underscoring its potential for abuse. By Corinne O’Keefe Osborn Corinne Osborn is an award-winning health and wellness journalist with a background in substance abuse, sexual health, and psychology. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Get Treatment for Addiction Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.