Bipolar Disorder Treatment Medications Print SSRIs or Selective Serotonin Reuptake Inhibitors Medically reviewed by Medically reviewed by Steven Gans, MD on August 05, 2016 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD Written by Written by Marcia Purse Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. Learn about our editorial policy Marcia Purse Updated on September 13, 2018 Bipolar Disorder Overview Symptoms & Diagnosis Causes Treatment Living With In Children Your Rights Jonathan Nourok / Getty Images An SSRI is a type of antidepressant sometimes used in combination with other medications to treat bipolar depression. Let's take examine a list of SSRIs and understand how they are used in bipolar disorder. What Are SSRIs? SSRIs, or selective serotonin reuptake inhibitors, are a class of antidepressants that increase the amount of the neurotransmitter serotonin available in the brain, which has been shown to be effective in the treatment of depressive disorders including bipolar depression. List of SSRIs A list of SSRIs is below, shown with the brand name followed by a generic name in parentheses. Celexa (citalopram)Lexapro (escitalopram)Luvox (fluvoxamine)Paxil (paroxetine)Prozac (fluoxetine)Symbyax, which is Prozac plus the antipsychotic Zyprexa (fluoxetine + olanzapine)Zoloft (sertraline) When SSRIs Are Used in Bipolar Disorder According to the American Psychiatric Association, using an antidepressant therapy alone to treat bipolar depression is not recommended. This is because using antidepressants, like SSRIs, to treat bipolar depression has been linked to triggering mania and rapid cycling. There is also some scientific debate that antidepressants are simply not beneficial in treating bipolar depression—although this is controversial. That being said, many people with bipolar depression are prescribed antidepressants, especially if they have responded well before to antidepressants, if their depression is severe, or if they are not responding to mood-stabilizing medications alone. For instance, in the latter case, if a person with bipolar depression is not responding to lithium or lamotrigine—mood-stabilizing medications—than their doctor may add on an antidepressant, like Paxil (paroxetine). What Happens When I Stop An SSRI? Here is a look at the causes and symptoms of SSRI Discontinuation Syndrome, the uncomfortable reaction some people have to cut down or quit certain types of antidepressants. Here are tips for both pill and capsule handling to ease the effects of lowering your dosage or discontinuing an SSRI antidepressant medication—when a too-abrupt transition could cause troubling symptoms. What Should I Do? If you have bipolar depression and you are taking an SSRI, be sure to discuss with your doctor the potential side effects, and also the signs of a manic episode and rapid cycling. It's important you take your medication, as prescribed. Do not stop your medication without consulting your doctor—this is for your safety and well-being. Was this page helpful? Thanks for your feedback! Dealing with racing thoughts? Always feeling tired? Our guide offers strategies to help you or your loved one live better with bipolar disorder. Sign up for our newsletter and get it free. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. American Psychiatric Association. Practice Guideline For The Treatment of Patients With Bipolar Disorder. Salvi V, Fagiolini A, Swartz HA, Maina G, & Frank E. The use of antidepressants in bipolar disorder. J Clin Psychiatry. 2008 Aug;69(8):1307-18. Continue Reading