Medications for Treating Panic Disorder

Medication is one of the most popular and effective treatment options for panic disorder, panic attacks, and agoraphobia. Your doctor may prescribe medication to reduce the intensity of panic attacks, decrease overall feelings of anxiety, and potentially treat co-occurring conditions, such as depression.

Medications for panic disorder are typically from one of two categories: antidepressants and anti-anxiety drugs.

This article discusses how medications are used to treat panic disorder and which medications are most often prescribed. It also covers some of the other treatment options that may be effective for panic symptoms.

Panic Disorder Treatment

Treatment for panic disorder may involve medication in addition to psychotherapy. In some cases, more than one medication may be prescribed to help manage symptoms of panic and anxiety.

For example, an antidepressant may be prescribed to help reduce the frequency of panic symptoms, while benzodiazepines may be used on an as-needed basis to help reduce the severity of panic attacks.

Psychotherapy can also be effective for treating panic disorder. Types of psychotherapy that may be helpful include cognitive behavioral therapy (CBT), exposure therapy, and panic-focused psychodynamic psychotherapy (PFPP).

Antidepressant Medications for Panic Disorder

When first introduced in the 1950s, antidepressants were primarily used to treat mood disorders. However, it was later discovered that these medications effectively help reduce anxiety, lessen the symptoms of panic, and decrease the intensity and frequency of panic attacks.

Antidepressants affect the chemical messengers in the brain, known as neurotransmitters. There are thought to be many different types of these chemical messengers that communicate between brain cells.

Selective Serotonin Reuptake Inhibitors (SSRIs)

Selective serotonin reuptake inhibitors (SSRIs) are a popular class of antidepressants prescribed to decrease symptoms of anxiety and depression. Serotonin is a naturally occurring neurotransmitter in the brain.

These medications work by influencing only serotonin ("selective") and by preventing serotonin absorption ("reuptake") by the nerve cells in the brain. By balancing serotonin functioning, SSRIs are able to reduce anxiety and improve mood.

Common SSRIs include:

• Celexa (citalopram)
• Paxil (paroxetine)
• Prozac (fluoxetine)
• Zoloft (sertraline)

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

Serotonin-norepinephrine reuptake inhibitors (SNRIs) also block the reuptake of serotonin and norepinephrine. Norepinephrine is a neurotransmitter that plays a role in concentration and alertness. 

Common SNRIs include:

• Cymbalta (duloxetine)
• Effexor XR (venlafaxine)

Research has found that SNRIs are effective for treating anxiety disorders, particularly social anxiety disorder. Side effects can occur while taking SNRIs and may include fatigue, insomnia, changes in appetite, and changes in sexual function.

Tricyclic Antidepressants (TCAs)

Tricyclic antidepressants (TCAs) have become less popular in treating anxiety and mood disorders since SSRIs were introduced. However, TCAs can still be an effective treatment option for people with anxiety disorders.

Like SSRIs, TCAs work to block the reuptake of the chemical messenger serotonin. Additionally, many TCAs also prevent the reuptake of norepinephrine, another neurotransmitter in the brain that is often associated with the fight-or-flight stress response.

Common TCAs include:

• Adapin, Sinequan (doxepin)
• Asendin (amoxapine)
• Elavil (amitriptyline)
• Norpramin (desipramine)
• Pamelor (nortriptyline)
• Surmontil (trimipramine)
• Tofranil (imipramine)
• Vivactil (protriptyline)

Monoamine Oxidase Inhibitors (MAOIs)

Monoamine oxidase inhibitors (MAOIs) are one of the earliest developed antidepressants used to effectively treat mood and anxiety disorders. MAOIs work by inhibiting the activity of the enzyme monoamine oxidase. 

This enzyme is involved in breaking down neurotransmitters like norepinephrine, serotonin, and dopamine. Dopamine helps regulate many functions, including movement, physical energy levels, and feelings of motivation.

Common MAOIs include:

• Emsam (selegiline)
• Nardil (phenelzine)
• Marplan (isocarboxazid)
• Parnate (tranylcypromine)

Anti-Anxiety Medications

Anti-anxiety medications are prescribed for their fast-acting relief of panic symptoms. These medications work to relax the central nervous system, which can lower the intensity of panic attacks and cause a person to feel calmer.

Due to their tranquilizing effect and rapid relief, anti-anxiety medications are often prescribed to treat panic disorder.

Benzodiazepines

Benzodiazepines are the most commonly prescribed class of anti-anxiety medication for panic disorder. Known for their sedative effect, these medications can quickly reduce panic attack symptoms and induce a more relaxed state.

Benzodiazepines slow down the central nervous system by targeting the gamma-aminobutyric acid (GABA) receptors in the brain, inducing a sense of relaxation. In spite of the potential risks and side effects of these medications, benzodiazepines have been found to safely and effectively treat panic disorder.

Common benzodiazepines include:

• Ativan (lorazepam)
• Klonopin (clonazepam)
• Librium (chlordiazepoxide)
• Valium (diazepam)
• Xanax (alprazolam)

Benzodiazepines can be habit-forming, so they are typically prescribed for short-term relief of anxiety symptoms.

A Word From Verywell

Medication can be helpful in the treatment of panic disorder and panic attacks, particularly when utilized in combination with psychotherapy. If you are experiencing symptoms of anxiety or panic, talk to your healthcare provider about which medications may be right for you.