How Modafinil Promotes Wakefulness

Plenty of people misuse cognitive-enhancing or psychostimulant drugs in a nonprescription capacity in order to increase productivity, combat fatigue and help with intellectual challenges. Although abuse of cognitive-enhancing drugs like amphetamine, methylphenidate, and modafinil (Provigil) is typically associated with university students--an estimated 7 to 20 percent of U.S. college students have reported misusing the drugs--other more surprising groups of people misuse these drugs, too. 

For example, 8.9 percent of surgeons surveyed in Germany reported the nonprescription use of cognitive-enhancing drugs.

Modafinil is supposed to be less addictive than other psychostimulants like amphetamine; however, we still don't understand exactly how this drug works or its long-term effects. Moreover, modafinil can cause some serious adverse effects and should be taken only when prescribed by a physician.

Modafinil is sometimes called a "wakefulness-promoting agent." Researchers believe that this drug works by increasing synaptic availability of neurotransmitters like monoamines, catecholamines, dopamine, serotonin, adenosine, histamine and noradrenaline. Modafinil affects the hypothalamus, hippocampus, and amygdala which are parts of the brain.

Modafinil is a tablet taken by mouth usually once-a-day. Most people who work during the day take the drug in the morning on either a full or empty stomach. However, shift workers who take the drug to promote wakefulness take the drug before their shifts begin.

Modafinil is used to treat problems with consciousness, arousal, and wakefulness. Some conditions treated with modafinil include the following:

• Narcolepsy
• Shift-work sleep disorder
• Obstructive sleep apnea
• Traumatic brain injury
• Adjuvant treatment of depression
• ADHD
• Palliative or end-of-life care

With respect to palliative or end-of-life care, many specialists choose to prescribe psychostimulants like modafinil because they improve mood faster than psychiatric medications. Furthermore, dependence is of less concern during end-of-life care.

Modafinil's most common adverse effects include the following:

• Vomiting
• Nausea
• Agitation
• Anxiety

Other adverse effects include the following:

• Insomnia
• Diarrhea
• Constipation
• Sweating
• Hoarseness
• Difficulty breathing
• Chest pain
• Irregular heartbeat
• Suicidal ideation (thoughts of suicide)
• Hallucination
• Rash
• Blisters
• Hives

Some of these adverse effects are scary and dangerous so be sure to contact your physician if you experience any of them.

Additionally, some of these adverse effects such as insomnia, restlessness, chest pain, nausea, and confusion may result from overdose with modafinil. If you suspect an overdose, call emergency services or contact a physician immediately.

Modafinil isn't for everyone, and before your physician prescribes you this medication, you should inform her of the following:

• Allergy to modafinil or armodafinil (an enantiomer of modafinil)
• Antidepressant medications including SSRIs, TCAs, and benzodiazepines
• Antiseizure medications like phenytoin and carbamazepine
• Antifungal medications like itraconazole and ketoconazole
• Illicit drug misuse or dependence
• Vitamins, nutritional supplements, and herbal supplements

People who have angina or recently had a heart attack shouldn't be given modafinil. Furthermore, it's unclear the effect that modafinil has on seizure threshold. Thus, modafinil may be dangerous in people with epilepsy and other seizure disorders.

There are no long-term studies on the effects of modafinil on the brain. A physician must carefully consider whether to prescribe modafinil and weigh the benefit of its stimulant properties with potentially adverse effects. Although modafinil is probably less addictive than other stimulants like amphetamines and methylphenidate, it still can likely lead to dependence. 

Please understand that every time a physician makes the decision to prescribe modafinil, this decision is patient specific. In other words, if you've prescribed modafinil or any other psychostimulant, this prescription is only for you. You shouldn't share or sell modafinil—or any prescription drug for that matter. Such diversion is harmful and illegal.