Mental Health News Most Comprehensive Microdosing Study to Date Finds it Improves Mental Health By Claire Gillespie Claire Gillespie Twitter Claire Gillespie is a freelance writer specializing in mental health. She’s written for The Washington Post, Vice, Health, Women’s Health, SELF, The Huffington Post, and many more. Learn about our editorial process Updated on August 14, 2022 Fact checked Verywell Mind content is rigorously reviewed by a team of qualified and experienced fact checkers. Fact checkers review articles for factual accuracy, relevance, and timeliness. We rely on the most current and reputable sources, which are cited in the text and listed at the bottom of each article. Content is fact checked after it has been edited and before publication. Learn more. by Karen Cilli Fact checked by Karen Cilli Karen Cilli is a fact-checker for Verywell Mind. She has an extensive background in research, with 33 years of experience as a reference librarian and educator. Learn about our editorial process Print Kat Ledbetter / Getty Images Key Takeaways Microdosing involves taking very small amounts of a drug in order to test its benefits while avoiding unwanted side effects.A recent study found evidence of the mental health benefits of microdosing psychedelic drugs like magic mushrooms.Participants who microdosed demonstrated greater improvements in mood and fewer symptoms of anxiety and depression than their non-microdosing peers. For many years, scientists have been investigating the possible benefits of psychedelic drugs like psilocybin (derived from "magic" mushrooms) and LSD for mental health issues like depression, post-traumatic stress disorder (PTSD), and addiction. A new study, published in Scientific Reports, provides further evidence of the therapeutic benefits of microdosing, which is when these drugs are taken in tiny amounts—that won't get you high. The participants who microdosed showed greater improvements in mood and mental health than those who didn't microdose. "There are an overwhelming number of anecdotal reports testifying to the benefits associated with psychedelic microdosing and a relative scarcity of empirical evidence to support these claims," says Joseph Rootman, MA, PhD student in Clinical Psychology at University of British Columbia, who co-led the study. "This gap in the literature calls for a quick response from the scientific community for investigation into this ongoing but largely untested practice." A Closer Look at the Study The study followed 953 people who took regular small amounts of psilocybin and a second group of 180 people who did not microdose. Over 30 days, participants were asked to complete a number of assessments relating to mental health symptomology, mood and, measures of cognition. For instance, part of the study was a smartphone finger tap test, which measures psychomotor ability and can be used as a marker for neurodegenerative disorders like Parkinson’s disease. "We generated a number of interesting novel findings," says Rootman. "For one, our study is the largest longitudinal study to date of microdosing psilocybin and one of the few studies to engage a control group." This allowed the researchers to investigate microdosing practices such as stacking, where psilocybin is combined with other non-psychedelic substances such as lion’s mane mushrooms. Joseph Rootman, MA There are an overwhelming number of anecdotal reports testifying to the benefits associated with psychedelic microdosing and a relative scarcity of empirical evidence to support these claims. — Joseph Rootman, MA "We found that the combination of psilocybin, lion's mane, and niacin was associated with an increased performance on a task of psychomotor performance, especially in older adults," says Rootman. He was particularly surprised to find that the stacked combination was more effective in individuals over age 55 than even psilocybin on its own. "Anecdotal reports suggest that the combination of psilocybin, lion’s mane, and niacin is beneficial in preventing cognitive decline among older adults and our findings, indeed, lined up with these suggestions in the context of a test of psychomotor ability," Rootman explains. Clinical psychologist Brian Pilecki, PhD, who has been studying psychedelics for over 20 years, points out an issue with the study. While it does have a control group, the participants were not randomly assigned to either the microdosing group or the control group (known as a double-blind study). "As a result, the study does not address the issue of how expectations may impact the perceived benefits of taking any substance (i.e. the placebo effect)," Pilecki explains. What to Know About Using Psilocybin for Depression The Benefits of Microdosing Previous studies have found that microdosers report reduced stress, improvements in mood, and a decrease in symptoms of depression, anxiety, post-traumatic stress, and obsessive–compulsive disorder. "In our study, microdosing was associated with greater observed improvements in mood, mental health, and psychomotor ability," Rootman says. From a scientific perspective, we still don't have a good understanding of the benefits of microdosing or how it works. "We also haven't really determined how psychedelics work in general, mostly because it hasn't been researched due to only relatively recent loosening of restrictions," Pilecki says. "What we do have is lots of reported benefits from individuals who say that microdosing has been helpful or positive for them." Placebo Effect May Explain Benefits of Psychedelic Microdosing The Future of Mental Health Care? Depression presents a major burden to public health globally, and a substantial number of patients do not respond to the presently available treatments. "Given this, the possibility for an alternative option that may help to attenuate the significant harm caused by this and other mental-mental health disorders merits consideration," says Rootman. "It is too early to say exactly how helpful microdosing is at this current time, which makes further research into the topic important as ever." Pilecki agrees that more research on psychedelics is required, whether it is microdosing or taking larger amounts. "In terms of microdosing, there is a lot of anecdotal reports of its benefits which warrants future study and investigation," he says. "It would be great to know what types of things microdosing helps most with, and what risks it might contain." What This Means For You New research has found promising evidence to support the claim that microdosing can benefit mental health. That being said, this is still very early data and much more research is needed before any concrete medical claims about these substances can be made. Smoking Toad Venom is the Hottest New Trend in Psychedelics 3 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Rootman JM, Kiraga M, Kryskow P, et al. Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls. Sci Rep. 2022;12(1):11091. doi:10.1038/s41598-022-14512-3 Cameron LP, Nazarian A, Olson DE. Psychedelic microdosing: Prevalence and subjective effects. J Psychoactive Drugs. 2020;52(2):113-122. doi:10.1080/02791072.2020.1718250 Tundo A, de Filippis R, Proietti L. Pharmacologic approaches to treatment resistant depression: Evidences and personal experience. World J Psychiatry. 2015;5(3):330-41. doi:10.5498/wjp.v5.i3.330 By Claire Gillespie Claire Gillespie is a freelance writer specializing in mental health. She’s written for The Washington Post, Vice, Health, Women’s Health, SELF, The Huffington Post, and many more. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? 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