Depression Treatment Medication Negative Effects of Antidepressants By Nancy Schimelpfening Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial process Updated on October 06, 2020 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Daniel B. Block, MD Medically reviewed by Daniel B. Block, MD LinkedIn Twitter Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Learn about our Medical Review Board Print Joe Raedle / Staff / Getty Images Table of Contents View All Table of Contents Common Side Effects Serious Side Effects Consult Your Doctor All medications, including antidepressants, can produce unwanted negative effects that we refer to as side effects. Some of these negative effects may be quite mild, while others may be more severe. In addition, they may go away or become less severe in time. If you experience problems with side effects, you should mention these to your doctor as they may be able to either give you strategies for coping with the side effects or prescribe a different antidepressant for you that has fewer or more tolerable side effects. Common Side Effects Some of the more common negative effects that people may experience with antidepressants include: Anxiety Blurred vision Constipation Dizziness Dry mouth Fatigue Feeling numb Insomnia Nausea Sexual side effects Weight gain Your doctor will be able to offer you appropriate coping strategies that can help. Your doctor may also make changes in your dose or transition you to a different medication that you can better tolerate. Side effects may decline after a few weeks once your body adapts to the medications, but some people experience some of these side effects for longer. Tactics that can help people cope with side effects include taking medication with food, increasing fluid intake, getting enough rest, and engaging in regular exercise. Coping With Nausea While on Antidepressants Serious Side Effects Though they are rare, some side effects of antidepressants are serious, so you should be aware of them. Among these are: Serotonin Syndrome Serotonin syndrome occurs when a neurotransmitter in the brain called serotonin reaches dangerously high levels. Symptoms of serotonin syndrome include confusion, agitation, muscle twitching, sweating, shivering, and diarrhea. In addition, severe cases may include symptoms such as very high fever, seizures, irregular heartbeat, and unconsciousness. This side effect is linked to the use of antidepressants including: Selective serotonin reuptake inhibitors (SSRIs) Serotonin-norepinephrine reuptake inhibitors (SNRIs) Monoamine oxidase inhibitors (MAOIs) Tricyclic antidepressants Other agents such as Viibryd, Trintellix, nefazodone, and trazodone Serotonin syndrome is generally triggered when an SSRI or SNRI medication is used in combination with a second medication that also affects serotonin levels, such as another antidepressant. If a person begins to exhibit any of the above symptoms, medical care should be sought immediately as this condition can be life-threatening. Is It Possible to Overdose on Antidepressants? Hyponatremia Hyponatremia is a condition in which sodium, or salt, levels in the blood fall to abnormally low levels. When this happens, dangerous amounts of fluid can build up inside the body's cells. This side effect can occur with SSRIs because these drugs can potentially impact the effects of a hormone involved in regulating sodium and fluid levels within the body. Older people may be especially prone to hyponatremia. Mild cases of hyponatremia can cause symptoms such as: ConfusionFeeling illHeadacheLoss of appetiteMuscle pain In more severe cases, people may also experience such symptoms as listlessness and fatigue, disorientation, agitation, psychosis, and seizures. In addition, hyponatremia has the potential to lead to coma or death. People who experience even mild symptoms of hyponatremia should seek immediate medical care. Suicidal Thoughts You should be aware that when you're first starting an antidepressant, you may experience a temporary worsening of your depression and potentially even increased thoughts of suicide. Studies indicate that this may be especially true for people younger than age 25. If you, or someone you are caring for, experience any worsening of depression, increased thoughts of suicide or death, or unusual changes in behavior in the first weeks after starting a new antidepressant, it is important to get medical assistance immediately. If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911. For more mental health resources, see our National Helpline Database. Allergic Reactions Allergic reactions can occur with antidepressants, either because a person is allergic to the active ingredient of the medication or because they are allergic to the dyes, fillers, or other inactive ingredients present in the pill or capsule. Symptoms of an allergic reaction can include swelling, itchy rash, hives, blisters, or difficulty breathing. A severe allergic reaction can become life-threatening if it blocks a person's ability to breathe. Medical help should be sought for an allergic reaction, especially if there is swelling in the face or breathing difficulty. Mania In people with bipolar disorder, antidepressants can potentially trigger an episode of mania, especially if used without a mood-stabilizing drug. Symptoms of mania include increased energy and activity, problems with sleeping, racing thoughts, impulsive behavior, grandiose thinking, extreme elevation of mood, irritability, and pressured speech. While mania is not necessarily life-threatening, it requires medical assistance to treat. Seizures Certain antidepressants can increase a person's risk of having a seizure. In some cases, the seizures may happen in a person who has never had one before. Most antidepressants do not increase seizure risk, although Wellbutrin (bupropion) is the antidepressant that is most likely to trigger one. Certain older antidepressants called tricyclics can increase a person's seizure risk as well. Generally, the newer antidepressants are less likely to trigger seizures. Seizures involve such symptoms as uncontrollable jerking movements of the arms and legs, staring spells, confusion, abnormal sensations, and loss of consciousness. All seizures should be reported to a doctor. If it is the first time a person has had a seizure, emergency services should be called. When to Call 911 A seizure lasts more than five minutesThe person does not wake upAnother seizure begins immediately afterwardThe person is pregnant, injured, or has diabetesThe seizure occurs in waterThere is anything unusual about the seizure compared to others that the person has had before Consult Your Doctor Keep in mind, however, that it is never a good idea to stop taking your antidepressant without first discussing it with your doctor. An unpleasant set of symptoms known as discontinuation syndrome may occur if you stop taking your medication too abruptly. Symptoms of discontinuation syndrome include: Agitation Anxiety Blurred vision Electric shock sensations Fatigue Hallucinations Insomnia Irritability Muscle pain Sweating Tingling Upset stomach Vivid dreams It's always best to taper off of your antidepressant very slowly with your doctor's guidance. This gives your brain time to get used to the changes, and you will notice fewer effects if you stick with your doctor's plan. 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CMAJ. 2017;189(21):E747. doi:10.1503/cmaj.160991 By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Speak to a Therapist for Depression Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.