Provisional and Differential Diagnosis Differences

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Your doctor is going to be very careful when diagnosing depression or any other mental disorder. There are certain steps to follow and he may not be entirely certain about the initial diagnosis.

In some cases, you may have either a "provincial" or "differential" diagnosis until more information can be gathered.

What does that mean and what's the standard procedure for a diagnosis? These are the questions we'll answer so you can fully understand the process. The key is to be patient and honest because this will help her create the proper treatment plan for you.

What Is a Provisional Diagnosis?

A provisional diagnosis means that your doctor is not 100 percent sure of a diagnosis because he needs more information. Essentially, based on the information he has, he is making an educated guess about the most likely diagnosis.

Under the newest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), a provisional diagnosis is indicated by placing the specifier "provisional" in parentheses next to the name of the diagnosis. For example, it might say something like 309.81 Posttraumatic Stress Disorder (provisional).

Once more information is gathered and a final diagnosis is made, this specifier is removed.

What Is a Differential Diagnosis?

A differential diagnosis means that there is more than one possibility for your diagnosis. Your doctor must differentiate between these to determine the actual diagnosis. Only after that is done can he choose the best method for treating you.

Unfortunately, there are currently no lab tests to identify depression. Instead, the diagnosis is based on your medical history and your symptoms. It is also necessary to rule out other potential causes because there are several conditions which may appear to be depression on the surface.

According to Dr. Michael B. First, Professor of Clinical Psychiatry at Columbia University and author of the DSM-5 Handbook of Differential Diagnosis, making a good differential diagnosis of depression involves six steps.

Step 1: Rule Out Malingering and Factitious Disorder

According to First, a doctor's initial step should be an attempt to determine whether or not a patient is faking his symptoms. In general, there are two possible reasons for this: malingering and factitious disorder.

Malingering Disorder

  • When someone feels they have something to gain from a particular diagnosis. For example, they may want to avoid certain responsibilities.

Factitious Disorder

  • When someone derives psychological benefit from taking the role of a sick person.

Step 2: Rule Out Drug-Related Causes

Certain drugs—both legal and illegal—can cause the same symptoms as depression. This can include the following:

Legal drugs

  • Beta-blockers: metoprolol and Inderal (propranolol)
  • Corticosteroids: cortisone, prednisone, methylprednisolone, and triamcinolone
  • Benzodiazepines: Xanax (alprazolam), Restoril (temazepam), and Valium (diazepam)
  • Drugs that affect hormones: birth control pills, estrogen replacement therapy
  • Stimulants: Ritalin (methylphenidate) and Provigil (modafinil)
  • Anticonvulsants: Tegretol (carbamazepine), Topamax (topiramate), and Neurontin (gabapentin)
  • Statins and other cholesterol-lowering drugs
  • Anticholinergic drugs: Bentyl

Illegal drugs

  • Alcohol
  • Phencyclidine: PCP (Angel Dust)
  • Hallucinogens: LSD, magic mushrooms (psilocybin), ketamine
  • Opioids
  • Cocaine
  • Inhalants (solvents, aerosol sprays, gases, nitrates)

It is fairly easy to know if someone is taking prescriptions, it may be necessary for a doctor to do a little investigation when it comes to drugs of abuse.

Clinicians can gain clues about illicit drug use, First says, by interviewing the patient. Sometimes, the family is interviewed as well. They can also look for signs of intoxication and perform blood or urine tests to screen for the presence of drugs.

Step 3: Rule Out General Medical Conditions

There are various conditions in which depression is a symptom. It is very important to rule these out because it may require treatment beyond psychotherapy or an antidepressant to remove or mitigate the underlying causes of depression. 

To do this, a clinician will ask about previously diagnosed conditions. They are particularly interested in those that may have begun around the same time as depression. Lab tests may be ordered to screen for conditions commonly associated with the symptoms of depression.

Some conditions commonly mistaken for depression include:

Step 4: Determine the Primary Disorder

Once other potential causes have been eliminated, it is necessary to distinguish which specific psychiatric disorder the patient has.

Clinicians must differentiate major depressive disorder from related mood disorders and other disorders which often coexist with depression. This is done by following the criteria established in the DSM-5.

Step 5: Differentiate Adjustment Disorders From Other Categories

There are times when a person's symptoms are significant but below the threshold to make another diagnosis.

First suggests that the clinician consider a diagnosis of Adjustment Disorder. This is a condition in which the symptoms are maladaptive—not typical—in response to the psychological stressor. This means that the symptoms keep you from coping with the disorder. Some common examples of maladaptive behavior include avoidance, passive communication, anger, and substance abuse.

If that category is not appropriate, they could then consider placing the diagnosis into either "Other" or "Unspecified" categories.

"Other"

  • Indicates that a person has a cluster of symptoms which do not presently exist as a discrete diagnostic category outlined in the DSM-5.

"Unspecified"

  • Indicates that a person's symptoms do not neatly fit into an existing category. However, with more information, a diagnosis may be possible.

Step 6: Establish Boundary With No Mental Disorder

Finally, the clinician needs to make a judgment call. They need to determine whether the patient is experiencing significant impairment or distress in his everyday life that would qualify as a mental disorder.

In addition, he must distinguish major depressive disorder from grief. While grief may cause significant impairment and distress, it may not necessarily qualify as a mental disorder.

A Word From Verywell

Properly diagnosing depression or any other mental health condition is the first step in treating the whole person. With a proper diagnosis, you can work with your psychiatrist to come up with an effective treatment plan, which involves a combination of medications, psychotherapy, and lifestyle changes, to get back in balance and feel like yourself again.

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Article Sources

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  1. Carpenter, WT, Regier, D. Diagnostic categories: Provisional, not otherwise classified, or place-holder? Schizophr Bull. 2016; 42(6): 1305-1306. doi:10.1093/schbul/sbw127

  2. First, MB. DSM-5 Handbook of Differential Diagnosis. Washington, DC: American Psychiatric Association. 2014. doi:10.1176/appi.books.9781585629992

  3. Butler, C, Zeman, AZJ. Neurological syndromes which can be mistaken for psychiatric conditions. J Neurol Neurosur PS. 2005; 76: i31-i38. doi:10.1136/jnnp.2004.060459

  4. O'Donnell, ML, Agathos, JA, Metcalf, O, Gibson, K, Lau, W. Adjustment disorder: Current developments and future directions. Int J Environ Res Public Health. Jul 2019; 16(14): 2537. doi:10.3390/ijerph16142537

  5. Zisook S, Corruble E, Duan N, et al. The bereavement exclusion and DSM-5. Depress Anxiety. 2012;29(5):425-43. doi:10.1002/da.21927

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