NEWS Mental Health News SNT Experimental Depression Treatment Nearly 80% Effective By Krystal Jagoo Krystal Jagoo Krystal Kavita Jagoo is a social worker, committed to anti-oppressive practice, who has worked for three academic institutions across Canada. Her essay, “Inclusive Reproductive Justice,” was in the Reproductive Justice Briefing Book. Learn about our editorial process Published on December 10, 2021 Fact checked Verywell Mind content is rigorously reviewed by a team of qualified and experienced fact checkers. Fact checkers review articles for factual accuracy, relevance, and timeliness. We rely on the most current and reputable sources, which are cited in the text and listed at the bottom of each article. Content is fact checked after it has been edited and before publication. Learn more. by Karen Cilli Fact checked by Karen Cilli Karen Cilli is a fact-checker for Verywell Mind. She has an extensive background in research, with 33 years of experience as a reference librarian and educator. Learn about our editorial process Share Tweet Email Print Maskot / Getty Images Key Takeaways Stanford Neuromodulation Therapy (SNT), a new type of magnetic brain stimulation was found to be effective in treating 78.6% of patients with severe depression.Based on this study, remission tends to occur within days and can last for months, with fatigue and headaches as side effects.This treatment may offer bright possibilities for treating severe depression effectively in a short period of time. When dealing with treatment-resistant depression, individuals may sometimes need to explore a variety of options to experience benefits. A recently published study in the American Journal of Psychiatry found that SNT was effective in treating 79% of patients with severe depression. This double-blind randomized clinical trial was conducted with 29 participants with treatment-resistant depression, and 78.6% of the treatment group were no longer depressed after 5 days of treatment. Based on these findings, SNT may hold a great deal of promise for individuals who struggle to find relief from severe depression. The Research In this study, participants ranged in age from 22 to 80 and had dealt with depression for nine years on average, despite trying pharmacotherapy. Historically, transcranial magnetic stimulation (TMS) treatment has required six weeks of once-daily sessions, but SNT targeted the magnetic pulses according to each patient’s neurocircuitry, based on an MRI. Within 4 weeks of treatment, 12 of the 14 participants who had received the SNT treatment had improved, and 11 of them met the Food and Drug Association (FDA) criteria for remission, while only 2 of the 15 participants who had received the active placebo met the criteria for remission. While these findings are promising, a limitation of this research is its small highly educated sample size, which reduces generalizability. Another limitation of this study is the fact that 45% of its participants had comorbid psychiatric diagnoses, which may impact the efficacy of treatment. How Is Transcranial Magnetic Stimulation (TMS) Used to Treat Depression? Potential Game-changer for Severe Depression Founder of the Stanford Brain Stimulation Lab, and Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University, Nolan Williams, MD co-developed the Stanford Neuromodulation Therapy (SNT) stimulation technology. Dr. Williams says, "After observing such dramatic results in our open-label study, where 90% of the participants entered remission of their depressive symptoms after treatment with SNT, we set up a double-blind, randomized controlled study, considered the gold standard of science." SNT uses electromagnetic pulses to mimic the language of the brain, so Dr. Williams explains how MRI techniques uncover each patient’s unique brain networks so that treatment can target specific brain circuits and retrain the brain through a series of magnetic pulses that induce brain activity. Dr. Williams explains, "By speaking to the brain in its own language, the time commitment from the patient has been reduced from 6 weeks to 5 days, and the effectiveness of TMS treatment is dramatically improved." Since the protocol uses higher doses than repetitive transcranial magnetic stimulation (rTMS) in optimally spaced intervals, Dr. Williams notes that these patterns of stimulation provide time for the brain to build proteins to rewire itself, resulting in sustained changes in neural circuits. Nolan Williams, MD By speaking to the brain in its own language, the time commitment from the patient has been reduced from 6 weeks to 5 days, and the effectiveness of TMS treatment is dramatically improved. — Nolan Williams, MD Mental health emergencies can be particularly difficult to manage, but Dr. Williams highlights how SNT may be a game-changer. "For example, if you have a heart attack or a stroke, you can go to the hospital and receive sophisticated treatments that are only available at the hospital," he says. Options increase as the acuity of the illness increases but Dr. Williams notes, "If a person is experiencing a mental health emergency and goes to the hospital, the same options aren't there, and the ability to receive more effective treatment in the hospital is drastically reduced or non-existent." Dr. Williams further explains, "More than 550,000 American adults are hospitalized annually for suicidal depression. The highest peak in suicide attempt and completion is immediately after discharge from the hospital." When people have tried everything medicine has to offer to treat their depression, they can feel hopeless, but Dr. Williams says SNT offers something new for those with treatment-resistant depression. Dr. Williams highlights, "Mental illnesses and substance use disorders have been rising steadily, and the pandemic has only added fuel to the fire. It’s vital to the state of mental health in America that we continue to further advance treatment and research for illnesses of the brain." What Is Transcranial Magnetic Stimulation (TMS)? Another Tool for Severe Depression Behavioral health medical director at Community Health of South Florida Inc., psychiatrist Howard Pratt, DO, says, “This is another tool in psychiatrists’ toolbox for treating depression. The bottom line here is to not give up on treating depression if you have had treatment fail in the past." Dr. Pratt notes, "The science is there, but for this study, the sample size is smaller than I would like to see. If we see these results with larger groups then we will have a better gauge as to how effective this treatment is.” Since the stigma of seeking mental health treatment may pose a barrier, Dr. Pratt highlights how it sometimes has individuals reaching past the most effective treatment, which is a combination of therapy and medication. Howard Pratt, DO The bottom line here is to not give up on treating depression if you have had treatment fail in the past. — Howard Pratt, DO Dr. Pratt explains, "This research reminds us we need to keep reaching. I thought the study was brilliant. It’s looking at taking similar TMS treatment, which takes about six weeks to achieve results, which is about the same as for an antidepression medication, down to five days.” When patients talk with their psychiatrist about these innovations, Dr. Pratt recommends that they understand how the standard care is the treatment of choice and should be prioritized as the first line of treatment. Dr. Pratt explains, "The patient and the psychiatrist really have to start with therapy and that means talking, having in-depth conversations before turning to administering magnetic pulses on people’s brains.” What This Means For You As this research study demonstrates, SNT treatment may revolutionize recovery from severe depression when therapy and medication prove futile. Especially given the impact of the pandemic on mental health, such advances may bring hope for treatment-resistant depression. MDMA Added to List of Beneficial Psychedelics in Treatment of PTSD 1 Source Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Cole EJ, Phillips AL, Bentzley BS, et al. Stanford neuromodulation therapy (SNT): A double-blind randomized controlled trial. AJP. 2021. doi:10.1176/appi.ajp.2021.20101429 By Krystal Jagoo Krystal Kavita Jagoo is a social worker, committed to anti-oppressive practice. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Speak to a Therapist Online Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.