The Health Benefits of St. John's Wort

St. John's Wort May Ease Depression

St. John's wort (Hypericum perforatum) is a flowering plant named for its bright yellow flowers which were said to bloom for the first time around St. John the Baptist's birthday. The word "wort" means "plant" in Old English.

People have been using St. John's wort for centuries. Today, the popular herb is often used to ease the symptoms of depression.

possible health benefits of St. John's wort
Verywell / Jessica Olah

Health Benefits

St.John's wort is widely believed to boost mood and provide some relief from depression. The herb is also being explored for the following health concerns:

An oil made from St. John’s wort has also been used topically for wound healing and for a variety of other skin conditions such as eczema and hemorrhoids.

Depression

Although the benefit of St. John's wort is still being explored, research suggests the herb can be more effective than a placebo in alleviating mild-to-moderate depression.

A 2015 study published in the Annals of Family Medicine examined whether antidepressants were more effective than a placebo for patients being treated for depression by their primary care doctor. setting. The scientists examined 66 previously published studies (with a total of 15,161 participants) and found that both antidepressant medications and St. John's wort extracts were more effective than a placebo for treating mild-to-moderate depression.

People taking St. John's wort were also more likely to continue treatment, as the herb was associated with fewer adverse effects compared to tricyclic and tetracyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), a noradrenaline reuptake inhibitor (NRI), a serotonin-noradrenaline reuptake inhibitor (SNRI; venlafaxine), and noradrenergic and specific serotonergic antidepressant agents (NaSSAs).

Major Depression

The most comprehensive research on St. John's wort and major depression include a report published in the Cochrane Database of Systematic Reviews in 2008. Researchers looked at 29 previously published clinical trials (with a total of 5489 participants) that compared the effects of St. John's wort to a placebo or standard antidepressant medication for a period of four to 12 weeks.

The study's authors found that St. John's wort extracts may be more effective than a placebo and were as effective as standard antidepressants. Additionally, the herb appeared to have fewer side effects. 

The authors noted that the studies conducted in German-speaking countries (where St. John's wort has a long history of use and is often recommended by physicians) reported more positive results than studies conducted in the United States and other countries.

Possible Side Effects

St John's wort can cause serious interactions with commonly used medications because of how it gets broken down by the liver. The herb can interact with medication in different ways. It can make some drugs less effective while making the effect of others stronger.

The types of medications that may interact with St. John's Wort includes:

  • Antibiotics
  • Antidepressants
  • Oral contraceptives
  • Immunosuppressants
  • Blood thinners such as warfarin
  • Sedatives and medications used to treat anxiety
  • Drugs used to treat cancer, heart conditions, and HIV/AIDS
  • Over-the-counter medications (for sleep, coughs, and colds)

St. John's wort can also interact with other herbs and supplements. You should avoid taking any nutritional supplement or remedy that can raise serotonin, such as 5-hydroxytryptophan (5-HTP), L-tryptophan, and SAMe, if you are taking St. John's wort.

Taking St. John's wort with antidepressants or any substance that raises serotonin can cause serotonin syndrome, a potentially dangerous condition resulting from an excess of serotonin. Symptoms of serotonin syndrome include confusion, fever, hallucinations, nausea, loss of muscle coordination, sweating, and shakiness.

If you experience any of these symptoms, stop taking St. John’s wort and seek immediate medical attention. Without treatment, the condition can be fatal.

The most common side effects reported by people taking oral St. John’s wort supplement for a short period of time include:

  • Mild stomach upset
  • Diarrhea
  • Dry mouth
  • Headache
  • Tiredness
  • Dizziness
  • Anxiety
  • Restlessness
  • Tingling
  • Allergic skin reactions
  • Sexual or erectile dysfunction
  • Vivid dreams
  • Liver injury
  • Psychosis (rare)
  • When used topically, St. John's wort may cause a skin rash.

St. John’s wort (both oral or topical) can increase the sensitivity of your skin and eyes to sunlight. If you have a condition such as Lupus or are taking medication that can cause photosensitivity (such as some acne medications) review the risks and benefits of taking St. John's wort with your doctor or pharmacist.

There may be certain situations where it would be unsafe for you to take a supplement such as St. John's wort, or you will need an adjusted dose.

For example, if you are pregnant, breastfeeding, trying to conceive, or taking oral contraceptives (birth control pills) it's important to talk with your doctor before you start taking St. John's wort.

St. John's wort may worsen symptoms in people with certain conditions, including:

Some research has indicated taking certain herbal supplements, including St. John's wort, may increase your risk of complications if you are put under anesthesia. You should not take St. John's wort for two weeks before having surgery.

If you have received an organ transplant, you will need to avoid St. John's wort as it can interact with the medications given to help prevent transplant rejection.

Dosage and Preparation

There is not enough scientific data to provide a standard recommended dose of St. John's wort, though there are doses commonly used by researchers who are investigating the herb's effect on depression.

In NIH-funded trials, participants were given a 300 mg dose of a specific concentration of St. John's wort extract three times a day (900 mg total per day). The maximum dose given was 1,800 mg per day. By the end of the eight-week trial, the average daily dose was 1,300 mg per day.

The amount of St. John's wort for you will depend on many different factors including your age, biological sex, and medical history. It's best to work with your doctor, pharmacist, and/or an alternative health practitioner to personalize your dose to ensure effectiveness and safety.

What to Look For

St. John's wort is widely available in pharmacies, supermarkets, and health food stores and comes in different doses. Check the Supplement Facts label for the product you choose to ensure you are getting the appropriate dose. This label also provides information about other ingredients the supplement may contain.

The National Institutes of Health (NIH) suggests looking for products with a seal of approval from a third-party organization that provides quality testing, such as U.S. Pharmacopeia, Consumer Lab, and NSF International.

A seal of approval from these organizations assures a product was properly manufactured, that it actually includes the ingredients listed on the label, and does not contain harmful levels of contaminants. A seal of approval does not guarantee a product's safety or effectiveness.

Other Considerations

If you or someone you know is living with depression, you may be seeking different options to manage your symptoms. While the research on St. John's wort is promising, it's crucial that you work with your health care provider and discuss whether it's appropriate for you, rather than trying it on your own.

Delaying or forgoing treatment for depression can have serious consequences. As you are deciding on treatment, remember to tell each health care provider you work with about all the medications you are taking, including herbal or nutritional supplements, to ensure no potentially dangerous interactions occur.

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Article Sources

  1. Linde K, Kriston L, Rücker G, et al. Efficacy and Acceptability of Pharmacological Treatments for Depressive Disorders in Primary Care: Systematic Review and Network Meta-Analysis. Ann Fam Med. 2015 Jan-Feb;13(1):69-79. 

  2. Linde K, Berner MM, Kriston L. St John's Wort for Major Depression. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD000448. 

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