The ADHD vs. Non-ADHD Brain

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Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder. This means there are differences in the ADHD brain that affect a child’s development. ADHD does not influence intelligence. It does, however, affect a person's ability to regulate attention and emotions, and it results in hyperactivity and impulsivity as well as organization problems.

Differences in the ADHD Brain

ADHD is a condition that comes under a lot of scrutiny. Naysayers question if it is real or say it is caused by lack of motivation, willpower, or bad parenting—none of which is true. However, if you or your child has ADHD, you can feel vulnerable to these comments.

Knowing that there are biological differences in the ADHD brain—compared to the brain of a person who does not have ADHD—can be validating for someone dealing with the condition, as it provides additional evidence of the realities of ADHD.

The differences can be divided into three areas: structure, function, and chemistry.


Watch Now: Strategies for Living Well With ADHD

Brain Structure

For many years, research showed there were clear structural differences in the ADHD brain. The largest review ever of ADHD patient brain scans was carried out at Radboud University Nijmegen Medical Centre and published in 2018.

Researchers reported that people with ADHD had smaller brain volume in five subcortical areas, and their total brain size was smaller, too. These differences were greater in children and less in adults.

Parts of the ADHD brain mature at a slower pace (approximately one to three years) and never reach the maturity of a person who does not have ADHD.

Another interesting finding was that the amygdala and hippocampus are smaller in the brains of people with ADHD. These areas are responsible for emotional processing and impulsivity and had previously not been definitively connected to ADHD.

Brain Function

There are several types of brain imaging techniques that allow researchers to study how the ADHD brain operates and functions. These include:

  • Functional magnetic resonance imaging (fMRI)
  • Positron emission tomography (PET)
  • Single-photon emission computer tomography (SPECT)

There are alterations in blood flow to various areas of the brains in people with ADHD compared to people who do not have ADHD, including decreased blood flow to certain prefrontal areas. Decreased blood flow indicates decreased brain activity.

The prefrontal area of the brain houses the executive functions and they are responsible for many tasks including planning, organizing, paying attention, remembering, and emotional reactions.

Evidence also suggests that ADHD may be related to dysfunctional brain connectivity. Research using resting-state MRIs suggests that individuals with ADHD may have increased functional connectivity in certain regions of the brain.

One study published in 2010 found that children with ADHD do not have the same connections between the frontal cortex of the brain and the visual processing area. This suggests that the ADHD brain processes information differently than a non-ADHD brain.

Brain Chemistry

The brain is a busy communication network where messages are relayed from one neuron (brain cell) to the next. There is a gap between neurons, which is called a synapse. In order for the message to be passed along, the synapse needs to be filled with a neurotransmitter. Neurotransmitters are chemical messengers, and each one is responsible for different functions.

The key neurotransmitters for ADHD are dopamine and noradrenaline. In the ADHD brain, there is dysregulation of the dopamine system. For example, there is either too little dopamine, not enough receptors for it, or the dopamine is not being used efficiently.

Stimulant medications help ADHD because they encourage more dopamine to be produced or keep dopamine in the synapses longer.


Brain scans cannot be used to diagnose ADHD. There is no objective test to diagnose ADHD. The diagnosis of ADHD requires a full evaluation by a qualified doctor, psychologist, or psychiatrist. Diagnosis includes:

  • An in-depth interview with the patient
  • A review of school reports and medical history
  • Tests to measure attention, distractibility, and memory.

With that information, the clinician can determine if the diagnostic guideline for ADHD set by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) is met.

While PET and fMRI scans can be useful for research, they really only give an insight into how the brain is functioning at the moment the test was performed. Brain scans do not take into account how the brain operates in different situations, in the way a clinical test can during a detailed interview.

In addition, the scan data that has been studied is generally based on group averages, and may not apply to any particular individual. The results have not been normed, which is when large quantities of data are gathered and compared.

7 Sources
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC; 2013.

  2. Mueller AK, Fuermaier AB, Koerts J, Tucha L. Stigma in attention deficit hyperactivity disorderAtten Defic Hyperact Disord. 2012;4(3):101-114. doi:10.1007/s12402-012-0085-3

  3. Hoogman M, Bralten J, Hibar DP, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysisLancet Psychiatry. 2017;4(4):310-319. doi:10.1016/S2215-0366(17)30049-4

  4. Kim BN, Kim JW, Kang H, et al. Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorderJ Psychiatry Neurosci. 2010;35(5):330-336. doi:10.1503/jpn.090168

  5. Sörös P, Hoxhaj E, Borel P, et al. Hyperactivity/restlessness is associated with increased functional connectivity in adults with ADHD: a dimensional analysis of resting state fMRIBMC Psychiatry. 2019;19(1):43. doi:10.1186/s12888-019-2031-9

  6. Mazaheri A, Coffey-corina S, Mangun GR, Bekker EM, Berry AS, Corbett BA. Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;67(7):617-23. doi:10.1016/j.biopsych.2009.11.022

  7. Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW. The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry. 2011;69(12):e145-157. doi:10.1016/j.biopsych.2011.02.036

By Jacqueline Sinfield
Jacqueline Sinfield is an ADHD coach, and the author of "Untapped Brilliance, How to Reach Your Full Potential As An Adult With ADHD."