Symptoms of Clinical Depression

symptoms of depression

Verywell / Joshua Seong

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The two "core" symptoms of depression are low mood and loss of interest in activities. In addition to those, people may also experience changes in appetite, trouble sleeping, tiredness, feelings of guilt, trouble concentrating, or thoughts of death.

While only a qualified medical or mental health provider can diagnose depression, there are certain warning signs that can help you identify whether you or someone you care about may be depressed.

The symptoms of depression may be different in different people. So while one person may struggle to get out of bed, someone else might be able to go to work every day without co-workers noticing anything unusual.

And sometimes symptoms that look like depression aren't really depression. Substance use issues, medical problems, medication side effects, or other mental health conditions may produce symptoms that look similar to depression. 

Signs and Symptoms

The DSM-5 recognizes several different types of depressive disorders. The two most common types include clinical depression, also referred to as major depressive disorder (MDD), and persistent depressive disorder (PDD). People with PDD often experience the same type of symptoms as those with MDD, but they are typically less severe and last longer.

There are over 1,000 different combinations of symptoms that could lead to an MDD diagnosis. If you recognize signs that you or someone you may know be depressed, professional help may be warranted. Depression is very treatable with medication, talk therapy, or a combination of the two.

Depressed Mood

Depressed mood is consistent with both major depression and persistent depressive disorder. In major depression, a person feels depressed most of the day. Children or adolescents, on the other hand, may appear more irritable than sad.

A person with a depressed mood may report feeling sad or "empty," or may cry frequently. Having a low mood is one of the two core symptoms which is used to diagnose depression.  

People with PDD experience a depressed mood more days than not for at least two years. As with MDD, children with PDD may appear more irritable than depressed. However, for a PDD diagnosis, they must experience this for at least one year.

Decreased Interest

The second core symptom of major depressive disorder is a decreased interest or pleasure in things that you once enjoyed, also known as anhedonia. (Sidenote: The DSM-5 does not explicitly use the term anhedonia, but it is captured in the main criteria as “decreased interest and pleasure in most activities most of the day.")

Anhedonia is different from apathy. While apathy refers to a lack of interest and motivation, anhedonia is a lack of feeling, specifically, pleasure. It is not uncommon for a person to experience apathy and anhedonia simultaneously.

Symptoms of anhedonia can be divided into the following two categories:

  • Physical anhedonia: Those with physical anhedonia are less able to experience sensory pleasures. For example, foods you once enjoyed now taste bland. Sex may not feel pleasurable or you may lose interest in it.
  • Social anhedonia: People with social anhedonia tend to experience decreased pleasure from social situations. For example, someone who used to love meeting up with their friends for brunch is now indifferent to attending these get-togethers or returning phone calls.

Changes in Appetite

Another common sign of depression is a change in how much you eat. For some people, this means a loss of appetite. You may have to force yourself to eat because eating has completely lost its appeal. Or maybe you simply don't have the energy to prepare meals.

Feelings of sadness or worthlessness can also lead to overeating. In these instances, food is typically being used as a coping mechanism. You may find that food elevates your mood, but when the temporary pleasure of eating is gone, you reach for more food to suppress your feelings.

One study followed thousands of men and women for a period of 11 years. Those who reported feelings of depression and/or anxiety during that time had larger changes in their weight and a greater chance of being diagnosed as obese.

Hunger is a biological need to eat while appetite is simply to desire to eat. A loss of appetite is when, despite hunger and your body's ongoing need for nutrients, you have no desire to eat.

Sleep Disturbances

Sleep disturbance is present in as many as 90% of people with depression. It can take the form of either difficulty sleeping (insomnia) or sleeping excessively (hypersomnia).

Insomnia is the most common and is estimated to occur in approximately 80% of people with depression. With insomnia, people may have trouble falling asleep or staying asleep. Less frequently, in about 15% to 25% of cases, people with depression find themselves sleeping too much. This is more likely in younger people.

Sleep issues can be both a cause of depression and a symptom of depression. Thus, improving your ability to sleep is important for making you feel better now and reducing your likelihood of a future depression relapse.

Psychomotor Disturbance

Psychomotor skills are skills where movement and thinking are combined. This includes things like balance and coordination, such as when picking a coin up off the floor or threading a needle.

Psychomotor disturbance is typically classified as either psychomotor agitation or psychomotor retardation.

  • Psychomotor agitation: This involves excessive motor activity associated with a feeling of inner restlessness or tension. The activity is usually purposeless and repetitive and consists of behaviors such as pacing, fidgeting, hand-wringing, and an inability to sit still.
  • Psychomotor retardation: The opposite of psychomotor agitation, this involves slowed speech, thinking, and body movements. This can hamper everyday life in many ways, from signing your name to getting out of bed to even keeping up in conversation.


Chronic feelings of fatigue can be a symptom of both persistent depressive disorder and major depressive disorder. This loss of energy, which can equate to feeling tired most if not all of the time, can interfere with your ability to function normally. 

Maybe you don't feel well enough to take care of your children or tend to your housework. Perhaps the fatigue is enough that you need to call in sick at work a lot because you can't get out of bed. The fatigue that comes with clinical depression can sometimes feel overwhelming.

Feelings of Worthlessness or Guilt

Depression can put a negative spin on everything, including the way you see yourself. You may think of yourself in unappealing and unrealistic ways, such as feeling as if you are worthless.

You may also find that have trouble letting a past mistake go, resulting in feelings of guilt. You might become preoccupied with these "failures," personalize trivial events, or believe that minor mistakes are proof of your inadequacy.

An example of this would be a relationship that ended after you had a fight with your partner and said some not-so-pleasant things. This could lead you to consider yourself the cause of the breakup while potentially ignoring other issues in your relationship, such as a partner who is abusive or a poor communicator.

Excessive, inappropriate guilt and feelings of worthlessness are common symptoms of major depressive disorder. In some cases, the feeling of guilt may be so severe that it leads to delusion, which is an inability to see things for what they really are, therefore holding onto false beliefs.

Difficulty Concentrating

Both major depressive disorder and persistent depressive disorder involve difficulty concentrating and making decisions. People with depression may recognize this in themselves, or others around them may notice that they're struggling to think clearly

This effect has been found especially in older adults. They may notice that they're having trouble processing thoughts quickly and attribute their symptoms to cognitive decline.

Recurrent Thoughts of Death

Recurrent thoughts of death that go beyond the fear of dying are associated with major depressive disorder. An individual with major depression may think about suicide, make a suicide attempt, or create a specific plan to kill themselves. 

The Centers for Disease Control and Prevention reports that more than nine million adult Americans have suicidal thoughts annually. Additionally, these thoughts are highest for those between the ages of 18 and 25.

If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 1-800-273-8255 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.

For more mental health resources, see our National Helpline Database.

Complications & Comorbidities

Clinical depression is one of the most common complications reported by people with chronic diseases and conditions, including heart disease, cancer, diabetes, obesity, and arthritis. Often, the illness triggers depression, especially in people who are biologically vulnerable to the disorder. 

It's not uncommon for people with depression to live with two disorders or illnesses at once. This is known as a comorbidity. For instance, someone with chronic pain may become depressed (and vice versa).

Similarly, substance use disorders and depression often coexist. Someone with depression may turn to alcohol to self-medicate, and alcohol use disorder can also cause someone to experience symptoms of depression.

While neither condition actually causes the other, they do often coexist and one condition can exacerbate the symptoms of the other.

The following are some common co-occurring conditions in people with clinical depression:

Common Myths or Misconceptions

Despite ongoing efforts by researchers, medical professionals, and patients to raise awareness, stigma continues to be a reality for people living with depression. This is partly because of the many damaging myths that exist.

These misconceptions can prevent someone from recognizing the signs and symptoms of depression or from getting the help they need. Here we debunk some common depression myths.

You Can "Get Over It"

Being diagnosed with depression does not mean that you are being "crazy" or weak. Nor is it your fault or something you can simply snap out of on your own.

Depression is caused by a complex mix of factors, including an imbalance of neurotransmitters (mood-regulating chemicals) in your brain. Just like people diagnosed with diabetes can’t will their pancreas to produce more insulin, you can’t “try harder” to overcome depression. It’s a real disease that requires proper treatment. 

Depression Only Causes Mental Symptoms

Depression certainly includes mental symptoms like sadness, anxiety, irritability, and hopelessness. But physical symptoms are also a reality for many people living with depression.

This can include fatigue, body aches, headaches, and digestive troubles. People with depression can also have a weaker immune system, potentially putting them at greater risk of catching the latest bug or virus.

Only Women Get Depressed

Depression can occur in people of any race, ethnic, or economic group, and at any age. Women are almost twice as likely as men to be diagnosed with depression, but the jury is still out on how much of this is due to women reporting and seeking treatment more often than men.

Children and adolescents can also be at risk for depression. Unfortunately, many children with depression go untreated because adults don't recognize the warning signs, which are often different when compared to adults.

Depression Is Untreatable

Although depression can make you feel hopeless, there is hope for those who seek a diagnosis and comply with treatment. In fact, depression is one of the most treatable types of mental illness, with 80% to 90% percent of people responding to treatment.

What's more, treatment doesn't just involve taking medication for the rest of your life. Therapy and lifestyle modifications also play a key role in managing symptoms and preventing relapse.

Get Advice From The Verywell Mind Podcast

Hosted by Editor-in-Chief and therapist Amy Morin, LCSW, this episode of The Verywell Mind Podcast shares what it means to have 'existential depression,' featuring Melissa & Doug's co-founder Melissa Bernstein.

Follow Now: Apple Podcasts / Spotify / Google Podcasts / RSS

A Word From Verywell

One of the dangers of depression is that its symptoms can keep people from seeking help. But if you notice these symptoms in yourself or someone you love, don't hesitate to talk to a mental health provider. Depression can make it hard to enjoy life fully, but you don't have to suffer needlessly. Effective help is available.

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Article Sources
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  1. Cleveland Clinic. Persistent depressive disorder. Updated 2015.

  2. Fried EI, Nesse RM. Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study. J Affect Disord. 2015;172:96-102. doi:10.1016/j.jad.2014.10.010

  3. Treadway MT, Zald DH. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev. 2011;35(3):537-555. doi:10.1016/j.neubiorev.2010.06.006

  4. Brumpton B, Langhammer A, Romundstad P, Chen Y, Mai X-M. The associations of anxiety and depression symptoms with weight change and incident obesity: The HUNT study. Intl J Obesity. 2012;37:1268-1274(2013). doi:10.1038/ijo.2012.204

  5. Tsuno N, Besset A, Ritchie K. Sleep and depression. J Clin Psychiatry. 2005;66(10):1254-1269. doi:10.4088/jcp.v66n1008

  6. Dauvilliers Y, Lopez R, Ohayon M, Bayard S. Hypersomnia and depressive symptoms: methodological and clinical aspects. BMC Med. 2013;11:78. doi:10.1186/1741-7015-11-78

  7. Fang H, Tu S, Sheng J, Shao A. Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. J Cell Mol Med. 2019;23(4):2324-2332. doi:10.1111/jcmm.14170

  8. Sobin C, Sackeim HA. Psychomotor symptoms of depression. Am J Psychiatry. 1997;154(1):4-17. doi:10.1176/ajp.154.1.4

  9. van den Kommer T, Comijs H, Aartsen M, Huisman M, Deeg D, Beekman A. Depression and cognition: How do they interrelate in old age? Am J Ger Psy. 2013;21(4):398-410. doi:10.1016/j.jagp.2012.12.015

  10. Centers for Disease Control and Prevention. Suicide: Facts at a glance. Published 2015.

  11. Zdanowicz N, Reynaert C, Jacques D, Dubois T. Depression and immunity: A psychosomatic unit. Psychiatr Danub. 2017;29(Suppl 3):274-278.

Additional Reading
  • Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Washington, DC: American Psychiatric Publishing; 2013.​