Addiction Coping and Recovery Overcoming Addiction Print Vivitrol Treatment for Alcoholism and Addiction How the Medication Changes Your Brain's Reaction to Alcohol Medically reviewed by Medically reviewed by Steven Gans, MD on August 05, 2016 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD Written by facebook twitter Written by Buddy T Buddy T is an anonymous writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. Learn about our editorial policy Buddy T Updated on June 03, 2019 Hero Images/Getty Images More in Addiction Coping and Recovery Overcoming Addiction Methods and Support Personal Stories Alcohol Use Addictive Behaviors Drug Use Nicotine Use Vivitrol is an extended-release formulation of naltrexone, an opioid receptor antagonist used in the treatment of alcoholism and opioid addiction. While naltrexone hydrochloride is for both daily and once-a-month dosages, Vivitrol is the once-a-month form of the medication. The U.S. Food and Drug Administration approved Vivitrol for the treatment of alcohol abuse in 2006. How It Works Vivitrol works by blocking the effect that opioids have on the brain, and reduces the cravings that many people experience after they quit. Physicians prescribe Vivitrol for patients who have already stopped drinking and using opioid drugs (such as morphine, heroin, and prescription pain medications) and who have gone through a detoxification process. With alcohol, it is not certain how Vivitrol actually works, but it seems to change how the brain responds to alcohol consumption. Monthly Injection You administer Vivitrol by intramuscular injection once a month. One of the main problems with the daily dosages of naltrexone was medication compliance; patients had to remember and be willing to take the pills each day. With the once-a-month shot, medication compliance is less of a factor in the treatment plan. Once-A-Month Naltrexone Injection Effective Is Vivitrol Right for You? Patients already completely detoxed from alcohol and opioids are candidates for Vivitrol. It is not intended to help someone stop drinking. According to the FDA, patients "must not have any opioids in their system when they start taking Vivitrol; otherwise, they may experience withdrawal symptoms from the opioids. Also, patients may be more sensitive to opioids while taking Vivitrol at the time their next scheduled dose is due. If they miss a dose or after treatment with Vivitrol has ended, patients can accidentally overdose if they restart opioid use." Patients with acute hepatitis or liver failure should not take Vivitrol. Vivitrol vs. Other Medications Vivitrol is the first non-narcotic, non-addictive, extended release medication approved for the treatment of opioid dependence. Methadone and buprenorphine, also approved for opioid addiction treatment, can be addictive. Methadone is available only through specialized clinics. Buprenorphine is available through doctors' offices, but it and methadone require daily doses. Side Effects According to the FDA, side effects of Vivitrol during trial studies include: Nausea and vomitingTirednessHeadacheDizzinessPainful jointsMuscle cramps Other potential serious side effects of Vivitrol include: Reactions at the injection site, which can be severe and may require surgical interventionLiver damageAllergic reactions, such as hives, rashes, facial swellingPneumoniaFeeling depressedSuicide, suicidal thoughts, and suicidal behavior Alkermes, the drug's manufacturer, claims the main side effects are: Inflammation of nasal passagesIncreased liver enzymesInsomnia Effectiveness Vivitrol works best in conjunction with an overall treatment program. Research shows it is more effective than medications requiring a daily dose and double-blind, placebo-controlled clinical trials show Vivitrol effectively prevents relapse and reduces drug cravings. FDA trials found Vivitrol patients are more likely to stay in treatment and to refrain from using illicit drugs and 36 percent were able to stay in treatment for the full six months without using drugs, compared with 23 percent in the placebo group. Naltrexone for Maintaining Drug Abstinence by Eliminating Desire Was this page helpful? Thanks for your feedback! Learn the best ways to manage stress and negativity in your life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Alkermes, Inc. Vivitrol.com Manufacturer's website. National Institute on Drug Abuse. "Important Treatment Advances for Addiction to Heroin and Other Opiates." U.S. Food and Drug Administration. "FDA Approves Injectable Drug to Treat Opioid-Dependent Patients." Continue Reading