What Are Mood Stabilizers?

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What Are Mood Stabilizers?

Mood stabilizers are psychiatric pharmaceutical medications prescribed to help control the mood swings present in bipolar disorders. These medications control the severity of the highs and lows experienced by restoring the chemical balance in the brain.

Most commonly, mood stabilizers are used to treat those with bipolar disorder. However, they can also be used to treat those with schizoaffective disorder, borderline personality disorder (BPD), and in some instances, depression.

Types of Mood Stabilizers

There are currently three main types of drugs used as mood stabilizers in the United States for various conditions.

Mineral (Lithium)

Lithium is an element that occurs naturally in the world — it is third on the periodic table. It was first discovered in Australian and Chilean mines in 1817. However, it would only have its mood-stabilizing effects recognized later in the century, and its usage would only be approved by the U.S. Food and Drug Administration (FDA) in 1970.

The exact mechanism of how lithium works as a mood stabilizer is not yet fully known. However, research has suggested it interacts with several neurotransmitters, chemicals, and neuron receptors in the brain cells. This has the overall impact of decreasing abnormal activity in the brain.

Lithium’s most recognized brand names include Eskalith, Lithobid, and Lithonate.

Common side effects of lithium include increased thirst and urination, headaches, nausea, diarrhea, dizziness or drowsiness and changes in appetite. However, with continual usage, some of these may decrease in severity.

Anticonvulsants

Certain anticonvulsants, also referred to as anti-seizure medications, are also used as mood stabilizers. Although they were initially used to treat seizures, they were found useful in treating bipolar disorder due to their ability to calm hyperactivity in the brain.

The most widely known anticonvulsants used as mood stabilizers include:

While Depakote and Tegretol are particularly useful in treating mania, Lamictal has been found to be more effective at treating and preventing depressive symptoms in bipolar disorder. Nevertheless, they’re found to be very useful in helping to stabilize moods overall.

Anticonvulsant side effects vary depending on the particular agent. Common side effects may include headaches, dry mouth, dizziness and drowsiness, fatigue, and weight gain. However, these may also lessen over time with continual use.

Antipsychotics

For those with bipolar disorder, acute episodes of mania can result in psychosis in up to 53% of individuals. Due to this, antipsychotics are often prescribed for the acute treatment of mania. In addition, the newer category of "atypical" antipsychotics also have mood stabilizing properties of their own.

The most commonly used antipsychotics for this purpose include:

While atypical antipsychotics are much less likely to cause extrapyramidal side effects than the earlier generation of antipsychotics, they are known to cause other side effects such as drowsiness, blurred vision, weight gain, and metabolic problems.

How They Work

It is not precisely known how these medications stabilize an individual’s mood. These agents have been found to impact a variety of functions within nerve cells in the brain. These include modulating enzymes and impacting ion channels, cell membranes, proteins, and receptors.

Of note, electroconvulsive therapy (ECT), which works by inducing a small seizure in the brain under anesthesia, is also known to have mood stabilizing effects. It is often used for mood episodes when medications aren't effective.

Conditions Used For

Mood stabilizers are usually used to treat the following conditions:

  • Bipolar disorder: This is the most common use for mood stabilizers, and the area where most research into their use is found. As a result, they are commonly prescribed and are an essential aspect of treatment for bipolar disorder. Responses to different types vary from person to person, so various treatment plans are individualized. Mood stabilizers can both treat mood episodes and prevent recurrence of these episodes. When combined with coping strategies, healthy lifestyle choices, and therapy, many individuals find their symptoms significantly lessen in severity.
  • Schizoaffective disorder: Schizoaffective disorder is a chronic mental health condition where individuals experience a combination of psychosis symptoms (hallucinations and delusions) and mood disorder symptoms (mania, hypomania and/or depression). Mood stabilizers have been found effective at stabilizing and preventing the highs and lows experienced by individuals who fall under the bipolar-specifier for schizoaffective disorder.
  • Borderline personality disorder: Mood stabilizers have been used for those experiencing emotional dysregulation and impulsivity.

Side Effects

Each type of mood stabilizer has its own unique side effects that vary from person to person. Here are some common side effects you can experience:

  • Headaches
  • Nausea
  • Vomiting
  • Dizziness
  • Constipation
  • Diarrhea
  • Weight gain or loss
  • Dry mouth
  • Fatigue

Many of these side effects may tend to diminish with continual medication use as your body adjusts. However, you should seek medical attention if they begin to interfere with your professional or personal life.

Warnings and Interactions

Those who take lithium regularly can sometimes experience a serious condition called lithium toxicity. The kidneys usually excrete lithium; however, the concentration can rise should this mechanism fail or the intake increases excessively.

In most cases, the signs of this toxicity are easily identified and managed. In addition, healthcare providers regularly monitor the lithium concentration levels through routine blood tests.

It is also recommended that those taking lithium ensure they are hydrated to maintain a healthy blood serum level. Long-term lithium usage can also result in chronic kidney disease and thyroid abnormalities, so healthcare providers will also check kidney and thyroid function in conjunction with treatment.

Other mood stabilizers like Tegretol and Depakote also require blood level testing to ensure the serum level remains at a steady concentration. Liver functions and blood counts are generally monitored when using these medications. It is also advised that individuals limit their alcohol usage when using these types of medication due to their ability to increase its effect.

It is also important to note that all antipsychotics carry a Black box warning due to their association with increased mortality in elderly patients with dementia.

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16 Sources
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  1. Alda M. Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics. Mol Psychiatry. 2015;20(6):661–670.

  2. Medline Plus. Lithium

  3. Grunze HCR. Anticonvulsants in bipolar disorder. Journal of Mental Health. 2010;19(2):127–141.

  4. Grunze HCR. The effectiveness of anticonvulsants in psychiatric disorders. Dialogues Clin Neurosci. 2008;10(1):77–89.

  5. Burton CZ, Ryan KA, Kamali M, et al. Psychosis in bipolar disorder: Does it represent a more “severe” illness? Bipolar Disord. 2018;20(1):18–26.

  6. Muralidharan K, Ali M, Silveira LE, et al. Efficacy of second generation antipsychotics in treating acute mixed episodes in bipolar disorder: a meta-analysis of placebo-controlled trials. J Affect Disord. 2013;150(2):408–414.

  7. Gould TD, Chen G, Manji HK. Mood stabilizer psychopharmacology. Clin Neurosci Res. 2002;2(3–4):193–212.

  8. Verdolini N, Hidalgo-Mazzei D, Murru A, et al. Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines. Acta Psychiatr Scand. 2018;138(3):196–222.

  9. Rybakowski JK. Genetic influences on response to mood stabilizers in bipolar disorder. CNS Drugs. 2013;27(3):165–173.

  10. National Alliance on Mental Health. Schizoaffective disorder.

  11. Wy TJP, Saadabadi A. Schizoaffective disorder. In: StatPearls. StatPearls Publishing; 2022.

  12. Belli H, Ural C, Akbudak M. Borderline personality disorder: bipolarity, mood stabilizers and atypical antipsychotics in treatment. J Clin Med Res. 2012;4(5):301–8.

  13. Hedya SA, Avula A, Swoboda HD. Lithium toxicity. In: StatPearls. StatPearls Publishing; 2022. 

  14. National Kidney Foundation. Lithium and Chronic Kidney Disease.

  15. Mental Illness Research Education and Clinical Center. Facts About Mood Stabilizers.

  16. Maust DT, Kim HM, Seyfried LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiatry. 2015;72(5):438–445.