Discovery and Functions of Acetylcholine

Acetylcholine molecule
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Acetylcholine (ACh) is an abundant neurotransmitter in the human body. It is found in both the central nervous system (CNS) and the peripheral nervous system (PNS).

The name acetylcholine is derived from its structure. It is a chemical compound made up of acetic acid and choline. Cholinergic synapses are those in which transmission is mediated by acetylcholine.

Why It's Important

Why is acetylcholine so important in the body? It serves a number of critical functions, many of which can be impaired by diseases or drugs that influence the function of this neurotransmitter.

Acetylcholine can be found in all motor neurons, where it stimulates muscles to contract. From the movements of the stomach and heart to the blink of an eye, all of the body's movements involve the actions of this important neurotransmitter.

It is also found in many brain neurons and plays an important role in mental processes, such as memory and cognition.


Acetylcholine was the first neurotransmitter to be identified. It was discovered by Henry Hallett Dale in 1914, and its existence was later confirmed by Otto Loewi. Both individuals were awarded the Nobel Prize in Physiology or Medicine in 1936 for their discovery.

Function in the Body

Acetylcholine has numerous functions in the body.


In the PNS, acetylcholine is a major part of the somatic nervous system. Within this system, it plays an excitatory role leading to the voluntary activation of muscles.

Within the autonomic system, acetylcholine controls a number of functions by acting on neurons in the ​sympathetic and parasympathetic systems. It is also involved in the contraction of smooth muscles and dilation of blood vessels, and it can promote increased body secretions and a slower heart rate.

Because acetylcholine plays an important role in muscle actions, drugs that influence this neurotransmitter can cause various degrees of movement disruption and even paralysis.

For example, the brain might send out a signal to move the right arm. The signal is carried by nerve fibers to the neuromuscular junctions. The signal is transmitted across this junction by the acetylcholine neurotransmitter, triggering the desired response in those specific muscles.

Brain and CNS

Acetylcholine also acts at various sites within the CNS, where it can function as a neurotransmitter and as a neuromodulator. It plays a role in motivation, arousal, attention, learning, and memory, and is also involved in promoting REM sleep.

Disrupted levels of acetylcholine may be associated with Alzheimer's disease. Drugs and substances that interrupt acetylcholine function can have negative effects on the body and can even lead to death. Examples of such substances include some types of pesticides and nerve gasses.

The venom of a black widow spider also interacts with acetylcholine. When a person is bitten by a black widow, their acetylcholine levels rise dramatically, leading to severe muscle contractions, spasms, paralysis, and even death.

A Word From Verywell

Acetylcholine is a critical neurotransmitter that plays an important role in the normal function of the brain and body. Disruptions in the release and function of this neurotransmitter can result in significant problems in areas such as memory and movement.

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