Schizophrenia What Is Catatonia? By Sara Lindberg, M.Ed Sara Lindberg, M.Ed Sara Lindberg, M.Ed., is a freelance writer focusing on mental health, fitness, nutrition, and parenting. Learn about our editorial process Updated on February 13, 2022 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Steven Gans, MD Medically reviewed by Steven Gans, MD Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Print Getty Images / Rune Johansen Table of Contents View All Table of Contents Definition Symptoms Causes Diagnosis Treatment Coping What Is Catatonia? Catatonia is a psychomotor disorder that affects both speech and behavior functions. It can manifest as a state of stupor and unresponsiveness or as restlessness, agitation, and confusion. Catatonia was first identified as a discrete syndrome in 1874 by Karl Kahlbaum. The early description of the condition was focused on motor symptoms, and treatment was focused on supportive care rather than medical interventions. Currently, the incidence of catatonia is a little more than 10 percent of patients with acute psychiatric illnesses, particularly affective disorders. However, some experts believe that many cases go unreported. There are three main forms of catatonia: akinetic, hyperkinetic, and malignant catatonia. Akinetic: The most common type of catatonia that features a lack of movement, staring, and non-responsive behavior. Hyperkinetic: This is the excited type of catatonia that involves impulsive movement. Malignant: This causes the most severe symptoms and can lead to other health problems, and in some instances, it can result in death. Catatonia used to be closely linked to schizophrenia. In fact, until recently, it was considered a subtype of schizophrenia. But it’s now more commonly associated with a broad spectrum of medical and psychiatric illnesses, particularly mood disorders. Catatonia Symptoms The symptoms of catatonia will vary depending on the severity and type. However, there are some signs and symptoms that will be common across cases of catatonia. Stupor: Lack of physical movement or speechMutism: Non-verbal or very little verbal communicationPosturing: Active maintenance of a posture against gravityWaxy flexibility: Slight resistance to positioning Negativism: Opposition or no response to instructions Stereotypy: Involuntary, rhythmic movement repeatedly performed over time, including body rocking, hand waving, shoulder shrugging, and more Echolalia: Repeating words said by other peopleEchopraxia: Mimicking movements done by other peopleAutomatic obedience: Exaggerated cooperation on the patient’s part when interacting with another person Some signs occur more frequently. One study involving more than 230 catatonic patients found that staring, immobility, mutism, and withdrawal were reported with a greater frequency than other symptoms. What Is Catatonic Depression? Causes of Catatonia The exact cause of catatonia is not clear. However, experts say a catatonic state can be triggered by a range of conditions, including psychiatric illness and neurological and other medical illnesses. Some common theories include a dysregulation in gamma-aminobutyric acid (GABA), which is the primary inhibitory neurotransmitter in the brain, a dysregulation in glutamate, dysregulation of dopamine, or abnormalities of metabolism in the thalamus and frontal lobes. Other common hypotheses for catatonia include the following: Psychiatric disorders: Schizophrenia, mood disorders such as depression and bipolar disorder, and affective disorder are all underlying conditions that can cause catatonia.Neurological disorders: Catatonia can be caused by brain disorders like neurodegenerative disease and encephalitis. It can also be triggered by strokes, neoplasms, or other diseases. Medical conditions: Although psychiatric conditions are the most common underlying cause, some medical conditions can also cause catatonia. Renal failure, progressive multifocal leukoencephalopathy, autoimmune, paraneoplastic, infectious, metabolic, and certain drug exposures, and poisonings can lead to the development of catatonia. It's important to note that the majority of cases will have a detectable underlying cause, but some catatonic cases can also arise from an unknown cause. Diagnosing Catatonia Diagnosing catatonia is based on clinical observations. Practitioners can use a scale to diagnose catatonia. One of the most commonly used scales is the Bush-Francis Catatonia Rating Scale. Other tools include the Rogers Catatonia Scale, the Northoff Catatonia Rating Scale, and the Braunig Catatonia Rating Scale. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), a patient must present (either during an examination or observed) with three or more of the following symptoms to be diagnosed with catatonia. Catalepsy Waxy flexibilityStuporAgitationMutismNegativism PosturingMannerisms StereotypyGrimacing EcholaliaEchopraxia Catatonia was separated from schizophrenia in the DSM-5. This allowed catatonia syndrome to be diagnosed as a specifier to a variety of major mental and medical disorders. This has made it easier for practitioners to diagnose the condition. Diagnostic and Statistical Manual (DSM) Overview Catatonia Treatment The treatment of catatonia generally falls under one of two categories: pharmaceutical or electroconvulsive therapy (ECT). Benzodiazepines: In general, the first line of defense for treating catatonia are medications, with benzodiazepines being the top pick. Lorazepam, which belongs to the benzodiazepines, is often administered in high doses sometimes ranging to over 20 milligrams per day. At this dosage, patients typically see a response relatively quickly. Glutamate antagonists: While not used very often, glutamate antagonists, and more specifically, amantadine, has shown some success in treating catatonia. Electroconvulsive therapy: In cases where a patient does not respond to benzodiazepines, a doctor may recommend electroconvulsive therapy (ECT). During ECT, a medical professional will administer a brief electrical stimulation through the brain while the patient is under anesthesia. The purpose is to trigger a brief seizure with the goal of causing changes in brain chemistry. In patients demonstrating symptoms of malignant catatonia, ECT is often recommended as the first treatment option since this type of catatonia has a high rate of mortality if not treated immediately. In many cases, mental health experts or doctors need to treat catatonia before they can accurately diagnose and address any underlying conditions. What to Expect During Electroconvulsive Therapy Coping With Catatonia Catatonia is a serious medical condition that requires prompt medical treatment. That said, if a caregiver or loved one is in need of support, information, or other services, reaching out to an expert can help them cope with the physical and emotional aspects of caring and living with someone with catatonia. A Word From Verywell If you suspect someone you know is experiencing catatonia, contact a doctor or call 911 right away. In some cases, catatonia can be serious and life-threatening. However, with a proper diagnosis and the right treatment plan, the prognosis is good. 6 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Wilcox J, Duffy P. The Syndrome of Catatonia. 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