Depression Types What Is Catatonic Depression? By Nancy Schimelpfening Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial process Updated on May 23, 2022 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Daniel B. Block, MD Medically reviewed by Daniel B. Block, MD LinkedIn Twitter Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Learn about our Medical Review Board Print JGI / Jamie Grill / Getty Images Table of Contents View All Table of Contents What Is Catatonic Depression? Symptoms of Catatonic Depression Causes of Catatonic Depression Diagnosis of Catatonic Depression Treatment for Catatonic Depression Coping What Is Catatonic Depression? Catatonic depression is when catatonia occurs concurrently with depression. Catatonia is a state in which a person experiences marked disturbances in motor activity. Although generally thought of as reduced engagement and activity, it may also manifest as excessive or peculiar motor symptoms. Catatonia can be a part of another mental disorder or medical condition, or it may be categorized as "unspecified." Unspecified catatonia includes all cases in which there is no major psychotic, affective, or medical disorder that can be diagnosed. Catatonia itself is not uncommon, affecting about 10% of people with psychiatric conditions in Western countries. However, it is rare for people with major depressive disorder to have it. When catatonia occurs with depression, it is generally within the context of bipolar disorder. In fact, people with symptoms of catatonia are most frequently diagnosed with bipolar disorder followed by schizophrenia, which is the second most common psychiatric condition associated with catatonia. If you or a loved one are struggling with depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area. For more mental health resources, see our National Helpline Database. Symptoms of Catatonic Depression Catatonia is a syndrome that includes many different signs and symptoms, some of which are fairly broad in nature. Possible manifestations can include: Stupor: Perhaps the most prominent sign is stupor. Stupor is characterized by a lack of mobility and speech.Posturing: Persons with catatonia are able to remain in the same posture for quite considerable periods of time.Waxy flexibility: The clinician who is examining someone with catatonia is able to position the individual in very uncomfortable poses which the individual will continue to maintain for a long period of time.Negativism: Attempts to move one of the catatonic person's body parts are met with resistance equal to the amount of strength that is being applied.Automatic obedience: People with catatonia automatically obey all instructions given by the examiner.Ambitendency: The person with catatonia alternates between cooperating with the examiner's instructions and resisting them.Psychological pillow: The catatonic individual lies down with their head a few inches above the bed, almost as if there is an invisible pillow resting under his head. This position can be maintained for an extended amount of time.Forced grasping: The individual repeatedly and forcibly grasps the examiner's hand when it is offered.Obstruction: The catatonic individual stops suddenly in the middle of a movement without any apparent reason for doing so.Echopraxia: This involves mimicking the actions of the person speaking.Aversion: A person with catatonia turns away when spoken to.Mannerisms: This symptom involves performing repeated, purposeful movements (e.g., saluting).Stereotypies: People with catatonia sometimes engage in repeated, non-purposeful movements (e.g., rocking).Motor perseveration: People with catatonia may also continue to make a particular movement even after it has lost its original relevance.Excitement: Another symptom of catatonia involves engaging in excessive and purposeless activity that is not driven by outside stimuli.Speech abnormalities: Speech may exhibit certain irregularities, such as repetition of what other people say or monotonous speech. Catatonic depression may also be characterized by other symptoms of depression such as low mood, feelings of hopelessness, poor concentration, and changes in sleep. Causes of Catatonic Depression While it is unknown exactly what causes people to become catatonically depressed, a number of theories have been put forth, including the following: Deficiency in gamma-aminobutyric acid (GABA) Dysregulation in glutamate Dysregulation in dopamine Abnormalities of metabolism in the thalamus and frontal lobes One evolutionary theory suggests that catatonia may be due to an exaggerated primal fear response. It is possible, these scientists suggest, that our prehistoric ancestors, who had to frequently deal with predators, evolved the ability to remain very still for long periods of time in order to avoid detection by dangerous animals. Catatonia, they say, might be this ancient defense mechanism being triggered into action by strong feelings of fear. Diagnosis of Catatonic Depression Diagnosing catatonic depression begins with conducting a health assessment of the person's symptoms. Doctors typically ask about when the symptoms first appeared. They will also want to know about anything that seems to make these symptoms improve or worsen. To diagnose catatonic depression, a physician or psychiatrist may often talk to family members or loved ones about the person's symptoms. A person who has catatonic depression may not be able to answer questions. Doctors must also rule out other conditions that may lead to similar symptoms. The "Diagnostic and Statistical Manual of Mental Disorders" (DSM-5) specifies that the diagnosis of catatonic depression requires the presence of at least three psychomotor symptoms. Diagnostic and Statistical Manual (DSM) Overview Treatment for Catatonic Depression Benzodiazepines and electroconvulsive therapy (ECT) are the two main treatments for catatonia, although certain other treatments, such as some atypical antipsychotics, may also be utilized. Benzodiazepines Benzodiazepines are the first-line choice for treating catatonia. They work by increasing the effects of the neurotransmitter GABA. This type of medication is also able to quickly provide relief for symptoms such as anxiety, sleeplessness, agitation, and muscle spasms. About 70% of people with catatonia do well with a benzodiazepine called Ativan (lorazepam). Benzodiazepine Uses, Indications, and Side Effects Electroconvulsive Therapy (ECT) Benzodiazepines are generally tried first, but ECT may be the first choice for malignant catatonia. ECT is performed under general anesthesia so that the individual does not experience any pain during the procedure. ECT is the most efficacious treatment available for catatonia. Research suggests that it works for about 80% to 100% of people with catatonia. Research suggests that benzodiazepines are an effective first-line treatment for catatonia and that ECT may be used as a second-line treatment if benzodiazepines are ineffective, but researchers suggest that ECT should be considered as a first choice intervention in instances of severe catatonia. The two therapies—prescription medication and ECT—may also be combined. How ECT Is Used for Treating Depression Other Treatments Some other treatments that may also be used include N-methyl-D-aspartate (NMDA) and repetitive transcranial magnetic stimulation (rTMS). Research suggests that N-methyl-D-aspartate (NMDA), an amino acid derivative and NMDA receptor agonist that mimics the actions of glutamate, shows some effectiveness in relieving catatonic symptoms. RTMS is a noninvasive procedure in which magnetic pulses are directed toward certain areas of the brain. These magnetic currents are thought to stimulate brain cells in a way that may reduce depression and anxiety. Such treatments are promising, but further research is needed to determine their effectiveness in treating catatonic depression. Press Play for Advice On Reducing Depression Hosted by Editor-in-Chief and therapist Amy Morin, LCSW, this episode of The Verywell Mind Podcast shares how you can use behavioral activation to reduce your depression. Click below to listen now. Subscribe Now: Apple Podcasts / Spotify / Google Podcasts Coping With Catatonic Depression Symptoms of catatonic depression are serious. If you suspect that you may be in the early stages of becoming catatonically depressed, the best thing you can do to cope is to get treatment as soon as possible from a medical or mental health professional. Seek help: While you are experiencing symptoms of catatonic depression, you may need to be hospitalized. As you are recovering, you may continue to require assistance and supportive care. A friend or loved one may need to help you with daily living tasks and to help you get to and from your treatment appointments.Avoid triggers: Certain triggers, such as drugs and alcohol, can sometimes play a part in triggering catatonia or symptoms of severe depression. Focus on minimizing your exposure to things that tend to make your symptoms worse.Adhere to your treatment: Once symptoms begin to improve, you may be able to manage your condition with antidepressants and psychotherapy. These treatments focus on treating the underlying depression. Carefully following your treatment plan may help reduce the risk of additional catatonic episodes. If you have a loved one who is catatonically depressed, you can help by learning to recognize the signs of catatonia. If you spot these signs, have a plan in place that will help you determine how to get your loved one treatment and care. A Word From Verywell While catatonia can be serious and life-threatening, the prognosis is good with appropriate treatment. While there is a lack of large-scale clinical studies examining current treatment approaches, the available research supports the effectiveness of both benzodiazepines and electroconvulsive therapy (ECT). Prompt recognition and treatment at the beginning of the catatonic state are essential for the best outcomes. ECT and rTMS for Treating Depression 5 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Liu, YW, et al. Refractory depression with catatonic features was remitted with administration of intravenous dopamine and consequent buproprion as maintenance treatment. Aust N Z J Psychiatry. 2016; 50(6): 599. doi:10.1177/0004867415616697 Moskowitz, AK. "Scared stiff": Catatonia as an evolutionary-based fear response. Psychol Rev. 2004; 111(4): 984-1002. doi:10.1037/0033-295X.111.4.984 Luchini, F, et al. Electroconvulsive therapy in catatonic patients: Efficacy and predictors of response. World J Psychiatry. 2015; 5(2): 182-192. doi:10.5498/wjp.v5.i2.182 Bhati, MT, Datto, CJ, and O'Reardon, JP. Clinical manifestations, diagnosis, and empirical treatments for catatonia. Psychiatry. 2007;4(3):46-52. PMID: 20805910. Sienaert P, Dhossche DM, Vancampfort D, De Hert M, Gazdag G. A clinical review of the treatment of catatonia. Front Psychiatry. 2014;5:181. doi:10.3389/fpsyt.2014.00181 Additional Reading Dhossche DM, Goetz M, Gazdag G, Sienaert P. New DSM-5 category unspecified catatonia is a boost for pediatric catatonia: Review and case reports. Neuropsychiatry. 2013;3(4):401-410. Sienaert P, Dhossche DM, Gazdag G. Adult catatonia: Etiopathogenesis, diagnosis and treatment. Neuropsychiatry. 2013;3(4):391-399. By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Speak to a Therapist for Depression Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.