Brain Health How the Peripheral Nervous System Works By Kendra Cherry Kendra Cherry Facebook Twitter Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology. Learn about our editorial process Updated on September 07, 2022 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Steven Gans, MD Medically reviewed by Steven Gans, MD Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Print Verywell / Gary Ferster Table of Contents View All Table of Contents Definition PNS Structures PNS Nerves PNS Diseases Treatment for PNS Conditions Frequently Asked Questions The peripheral nervous system includes the nerves and ganglia outside the brain and spinal cord. The PNS includes the peripheral nerves, neuromuscular junctions, cranial nerves, and spinal nerves. This system also carries information to and from the central nervous system. The peripheral nervous system (PNS) is made up of two divisions: the somatic nervous system and the autonomic system. Each part of this system plays a vital role in how information is communicated throughout the body. This article discusses what the peripheral nervous system is, how it works, and the influence that it has on how the body functions, including what happens when there is a problem affecting the PNS. What Is the Peripheral Nervous System? The nervous system is divided into two parts: the central nervous system and the peripheral nervous system. The central nervous system (CNS) includes the brain and spinal cord, while the peripheral nervous system includes all of the nerves that branch out from the brain and spinal cord and extend to other parts of the body, including muscles and organs. The primary role of the PNS is to connect the CNS to the organs, limbs, and skin. The nerves of the PNS extend from the central nervous system to the outermost areas of the body. The peripheral system allows the brain and spinal cord to receive and send information to other areas of the body, which allows us to react to stimuli in our environment. The four primary functions of the PNS are to: Control autonomic body functionsControl motor movementsDigestionRelay sensory information to the central nervous system Examples of processes controlled by the peripheral nervous system include dilating or constricting the pupils in response to light, stimulating digestion, activating the sweat response, controlling blood flow, and regulating heart rate. The nerves that make up the peripheral nervous system are actually the axons or bundles of axons from nerve cells or neurons. In some cases, these nerves are very small, but some nerve bundles are so large that they can be seen by the human eye. Structures of the Peripheral Nervous System The peripheral nervous system itself is divided into two parts: the somatic nervous system and the autonomic nervous system. Each of these components plays a critical role in how the peripheral nervous system operates. The Somatic Nervous System The somatic system is the part of the peripheral nervous system responsible for carrying sensory and motor information to and from the central nervous system. The somatic nervous system derives its name from the Greek word soma, which means "body." The somatic system is responsible for transmitting sensory information as well as for controlling voluntary movement. This system contains two major types of neurons: Motor neurons: Also called efferent neurons, motor neurons carry information from the brain and spinal cord to muscle fibers throughout the body. These motor neurons allow us to take physical action in response to stimuli in the environment. Sensory neurons: Also called afferent neurons, sensory neurons carry information from the nerves to the central nervous system. The sensory neurons allow us to take in sensory information and send it to the brain and spinal cord. The Autonomic Nervous System The autonomic system is the part of the peripheral nervous system that's responsible for regulating involuntary body functions, such as blood flow, heartbeat, digestion, and breathing. In other words, it is the autonomic system that controls aspects of the body that are usually not under voluntary control. This system allows these functions to take place without needing to consciously think about them happening. The autonomic system is further divided into two branches: Sympathetic system: By regulating the flight-or-fight response, the sympathetic system prepares the body to expend energy to respond to environmental threats. When action is needed, the sympathetic system triggers a response by accelerating heart rate, increasing breathing rate, boosting blood flow to muscles, activating sweat secretion, and dilating the pupils. Parasympathetic system: This helps maintain normal body functions and conserve physical resources. Once a threat has passed, this system will slow the heart rate, slow breathing, reduce blood flow to muscles, and constrict the pupils. This allows the body to return to a normal resting state. Recap The PNS is made up of two divisions: the somatic nervous system and the autonomic nervous system. The somatic system contains sensory and motor neurons. It sends and receives sensory information and motor signals. The autonomic system is responsible for regulating involuntary body functions. Nerves in the Peripheral Nervous System The PNS is composed of nerves that are responsible for carrying signals between the central nervous system and the parts of the body that lie outside the CNS. This includes information from the senses, organs, and muscles. The axons of these nerve cells are bundled together and can be found throughout the body. Information is received by the dendrites of these cells, the information travels down the axon to the cell body. The message can then be communicated to other cells. The nerves that make up the peripheral nervous system connect with either the spinal cord or brain in order to transmit information to the CNS. PNS Nerves The main nerves that make up the peripheral nervous system include:Brachial plexusFemoral nerveLateral femoral cutaneous nervePeroneal nerveSciatic nerveSpinal accessory nerveTibial nerve Spinal Nerves Spinal nerves are responsible for transmitting information from the muscles, organs, and glands to the spinal cord. There are 31 spinal nerves that branch out to different areas of the body from the spinal cord. Cranial Nerves The cranial nerves are responsible for the receptors found in the head and neck area. Instead of connecting with the spinal cord, these nerves travel directly to the brain. There are 12 pairs of cranial nerves that transmit motor and sensory information from areas including the face, mouth, eyes, nose, and ears. Recap The PNS is made up of cranial nerves that connect directly with the brain and spinal nerves that connect with the spinal cord. Diseases of the Peripheral Nervous System There are a number of diseases and disorders that can affect the peripheral nervous system. Problems with the sensory and motor neurons in the PNS can result in changes in sensation, muscle weakness, or muscle paralysis. Some of the conditions that can affect the PNS include: Amyotrophic lateral sclerosis (ALS)Carpal tunnel syndromeDiabetesEpstein-Barr virusGuillain-Barre syndromeLupusPeripheral neuropathyPeripheral nerve injuriesRheumatoid arthritisThoracic outlet syndromeTumorsVitamin deficiency Symptoms of PNS diseases and disorders can include numbness, pain, tingling, burning, sensitivity to touch, and muscle weakness. Recap Disorders, injuries, toxins, and viruses can cause problems with the peripheral nervous system. Such conditions can lead to symptoms related to sensation, muscle strength, and muscle control. What Is Stiff-Person Syndrome (SPS)? Treatment for PNS Conditions Treatment for peripheral nerve problems depends on the cause and focuses on treating the underlying disorder and offering supportive care. For example, some PNS conditions may be caused by injury while others may be related to underlying health conditions, viruses, toxins, or genetic disorders. In addition to treating conditions that may be causing dysfunction or damage to PNS nerves, treatment may also involve surgery, physical therapy, occupational therapy, speech/language therapy, and respiratory support. A Word From Verywell The peripheral nervous system plays a critical role in motor and sensory function. If you are experiencing symptoms such as muscle weakness, numbness, loss of sensation, or sensitivity, talk to a healthcare provider for further evaluation. Frequently Asked Questions What does the peripheral nervous system do? The nerves of the peripheral nervous system are responsible for relaying information between the body and the brain. This includes involuntary body functions such as breathing, blood flow, and heartbeat as well as sensory information and control of voluntary movement. What is the peripheral nervous system made up of? The peripheral nervous system is made up of the nerves and ganglia that lie outside of the brain and spinal cord. It begins with the spinal nerves that branch off from the spinal cord and the cranial nerves that connect directly to the brain. What are the two divisions of the peripheral nervous system? The two divisions of the PNS are the somatic nervous system and the autonomic nervous system. The somatic system includes the nerves that transmit motor and sensory information to and from the CNS. The autonomic system regulates automatic body functions including digestion and blood pressure. How would an injury to the central nervous system affect the peripheral nervous system? Injuries to the CNS may affect the ability of the brain and spinal cord to send signals to the peripheral nervous system. For example, damage to the spinal cord may affect the ability to transmit motor and sensory information to the rest of the body.Some research suggests that traumatic brain injury may be associated with an increased risk for disorders that can affect the peripheral nervous system, such as ALS. 7 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Goldstein DS. Adrenal responses to stress. Cell Mol Neurobiol. 2010;30(8):1433–1440. doi:10.1007/s10571-010-9606-9 Bican O, Minagar A, Pruitt AA. The spinal cord: a review of functional neuroanatomy. Neurol Clin. 2013;31(1):1-18. doi:10.1016/j.ncl.2012.09.009 Cleveland Clinic. Cranial nerves. National Institute of Neurological Disorders and Stroke. Peripheral neuropathy fact sheet. Cleveland Clinic. Neuropathy (peripheral neuropathy). Columbia University Irving Medical Center. Peripheral nerve disorders. Evans TM, Jaramillo CA, Sataranatarajan K, et al. The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse model of motor neuron disease. Neuroscience. 2015;298:410-423. doi:10.1016/j.neuroscience.2015.04.041 Additional Reading Coon D, Mitterer JO. Introduction to Psychology: Gateways to Mind and Behavior With Concept Maps and Reviews. Cengage Learning. Eysenck MW. Simply Psychology. Taylor & Francis. By Kendra Cherry Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? 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