Depression Causes The History of Depression Accounts, Treatments, and Beliefs Through the Ages By Nancy Schimelpfening Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial process Updated on April 19, 2022 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Amy Morin, LCSW Medically reviewed by Amy Morin, LCSW Facebook LinkedIn Twitter Amy Morin, LCSW, is the Editor-in-Chief of Verywell Mind. She's also a psychotherapist, the author of the bestselling book "13 Things Mentally Strong People Don't Do," and the host of The Verywell Mind Podcast. Learn about our Medical Review Board Print De Agostini / Archivio J. Lange / Getty Images Table of Contents View All Table of Contents Earliest Accounts Ancient Beliefs Common Era 18th and 19th Centuries 19th and 20th Centuries Today's Understanding While no single person can be credited with the discovery of depression, there are many great thinkers whose ideas contributed—and continue to contribute—to our growing knowledge of what this illness really is. In order to better understand how researchers, doctors, and psychologists think about this condition today, it can be helpful to take a look back at the history of depression. What Is Clinical Depression? Earliest Accounts of Depression The earliest written accounts of what is now known as depression appeared in the second millennium B.C.E. in Mesopotamia. In these writings, depression was discussed as a spiritual rather than a physical condition. Like other mental illnesses, it was believed to be caused by demonic possession. As such, it was dealt with by priests rather than physicians. The idea of depression being caused by demons and evil spirits has existed in many cultures, including those of the ancient Greeks, Romans, Babylonians, Chinese, and Egyptians. Because of this belief, it was often treated with methods such as beatings, physical restraint, and starvation in an attempt to drive the demons out. While many believed that demons were the root cause of depression, there were a number of ancient Greek and Roman doctors who believed that depression was a biological and psychological illness. Greek and Roman doctors used therapeutic methods such as gymnastics, massage, diet, music, baths, and a medication containing poppy extract and donkey's milk to treat their patients. Ancient Greek and Roman Philosophy Hippocrates, a Greek physician, suggested that depression (initially called "melancholia") was caused by four imbalanced body fluids called humours: yellow bile, black bile, phlegm, and blood. Specifically, he thought that melancholia was caused by too much black bile in the spleen. Hippocrates' treatments of choice included bloodletting, baths, exercise, and diet. A Roman philosopher and statesman named Cicero, in contrast, believed that melancholia had psychological causes such as rage, fear, and grief. In the last years before the common era, in spite of some steps toward believing in more physical and mental causes of depression, it was still a very common belief among even educated Romans that depression and other mental illnesses were caused by demons and by the anger of the gods. The Common Era During the common era, many barbaric and primitive treatments for depression continued to be the norm. Cornelius Celsus (25 BCE to 50 CE) reportedly recommended the very harsh treatments of starvation, shackles, and beating in cases of mental illness. A Persian doctor named Rhazes (865–925 CE), however, did see mental illness as arising from the brain. He recommended such treatments as baths and a very early form of behavior therapy which involved positive rewards for appropriate behavior. During the Middle Ages, religion, especially Christianity, dominated European thinking on mental illness, with people again attributing it to the devil, demons, or witches. Exorcisms, drowning, and burning were popular treatments of the time. Many people were locked up in so-called "lunatic asylums." While some doctors continued to seek physical causes for depression and other mental illnesses, they were in the minority. During the Renaissance, which began in 14th century Italy and spread throughout Europe during the 16th and 17th centuries, witch hunts and executions of the mentally ill were still quite common; however, some doctors were revisiting the idea of mental illness having a natural rather than a supernatural cause. In the year 1621, Robert Burton published "Anatomy of Melancholy," in which he outlined the social and psychological causes of depression (such as poverty, fear, and loneliness). In this book, he made recommendations like diet, exercise, travel, purgatives (to clear toxins from the body), bloodletting, herbs, and music therapy in the treatment of depression. The Age of Enlightenment During the 18th and 19th centuries, also called the Age of Enlightenment, depression came to be viewed as a weakness in temperament that was inherited and could not be changed. The result of these beliefs was that people with this condition should be shunned or locked up. During the latter part of the Age of Enlightenment, doctors began to suggest the idea that aggression was at the root of the condition. Treatments such as exercise, diet, music, and drugs were now advocated and doctors suggested that it was important to talk about your problems with your friends or a doctor. Other doctors of the time spoke of depression as resulting from internal conflicts between what you want and what you know is right. And yet others sought to identify the physical causes of this condition. Treatments during this period included water immersion (staying underwater for long as possible without drowning) and using a spinning stool to put the brain contents back into their correct positions. Additional treatments included: Diet changesEnemasHorseback ridingVomiting Benjamin Franklin is also reported to have developed an early form of electroshock therapy during this time. Modern Treatments for Depression The 19th and 20th Century In 1895, the German psychiatrist Emil Kraepelin became the first to distinguish manic depression, what we now know as bipolar disorder, as an illness separate from dementia praecox (the term for schizophrenia at the time). Around this same time, psychodynamic theory and psychoanalysis—the type of psychotherapy based on this theory—were developed. Psychoanalytic Explanations In 1917, Sigmund Freud wrote about mourning and melancholia where he theorized about melancholia as being a response to loss, either real (for example, a death) or symbolic (such as failure to achieve the desired goal). Freud further believed that a person's unconscious anger over their loss leads to self-hatred and self-destructive behavior. He felt that psychoanalysis could help a person resolve these unconscious conflicts, reducing self-destructive thoughts and behaviors. Other doctors during this time, however, saw depression as a brain disorder. Behavioral Explanations The behaviorist movement in psychology contributed to the idea that behaviors are learned through experience. The behaviorists rejected the idea that depression was caused by unconscious forces and instead suggested that it was a learned behavior. Just as these depressive behaviors had been learned, they could also be unlearned. Principles of learning such as association and reinforcement could be used to establish and strengthen more effective, healthier behaviors. While psychologists today recognize that experience is not the sole determinant of behavior, behaviorism led to the development of a number of treatment approaches that continue to play an important role in the treatment of depression and other mental disorders. Cognitive Explanations During the 1960s and 1970s, cognitive theories of depression began to emerge. The cognitive theorist Aaron Beck proposed that the way that people interpret negative events could contribute to symptoms of depression. Beck suggested that negative automatic thoughts, negative self-beliefs, and errors in processing information were responsible for depressive symptoms. According to Beck, depressed people tend to automatically interpret events in negative ways and view themselves and helpless and inadequate. The psychologist Martin Seligman suggested that learned helplessness could play a role in the development of depression. According to this theory, people often give up on trying to change their situation because they feel that nothing they do will make a difference. This lack of control leaves people feeling helpless and hopeless. The emergence of these cognitive models of depression played an important role in the development of cognitive behavioral therapy (CBT), which has been shown to be effective in the treatment of depression. Press Play for Advice On Dealing With Hopelessness Hosted by Editor-in-Chief and therapist Amy Morin, LCSW, this episode of The Verywell Mind Podcast shares how you can manage feelings of hopelessness. Click below to listen now. Follow Now: Apple Podcasts / Spotify / Google Podcasts Biological and Medical Explanations Where older conceptualizations of depression stressed the role of early experiences, more recent approaches increasingly stress the biopsychosocial model that looks at the biological, psychological, and social factors that play a role in depression. During the 1970s, the medical model of mental disorders emerged and suggested that all mental disorders are primarily caused by physiological factors. The medical model views mental health conditions in the same way as other physical illnesses, which means that such conditions can also be treated with medication. Biological explanations for depression focus on factors such as genetics, brain chemistry, hormones, and brain anatomy. This view played an important role in the development and increased use of antidepressants in the treatment of depression. How the Medical Model Explains Mental Disorders The 19th and 20th Century Treatments During the late 19th and early 20th centuries, treatments for severe depression generally weren't enough to help patients. Desperate for relief, many people turned to lobotomies, which are surgeries to destroy the brain's prefrontal lobe. Though reputed to have a "calming" effect, lobotomies often caused personality changes, a loss of decision-making ability, poor judgment, and sometimes even death. Electroconvulsive therapy (ECT), which is an electrical shock applied to the scalp in order to induce a seizure, was also sometimes used for patients with depression. In the 1950s and 60s, doctors divided depression into subtypes of "endogenous" and "neurotic" or "reactive." Endogenous depression was thought to result from genetics or some other physical defect, while the neurotic or reactive type of depression was believed to be the result of some outside problems such as a death or loss of a job. The 1950s were an important decade in the treatment of depression thanks to the fact that doctors noticed that a tuberculosis medication called isoniazid seemed to be helpful in treating depression in some people. Where depression treatment had previously been focused only on psychotherapy, drug therapies now started to be developed and added to the mix. In addition, new schools of thought, such as cognitive behavioral and family systems theory emerged as alternatives to psychodynamic theory in depression treatment. One of the first drugs to emerge for the treatment of depression was known as Tofranil (imipramine), which was then followed by a number of other medications categorized as tricyclic antidepressants (TCAs). Such drugs provided relief for many people with depression but were often accompanied by serious side effects that included weight gain, tiredness, and the potential for overdose. Other antidepressants later emerged, including Prozac (fluoxetine) in 1987, Zoloft (sertraline) in 1991, and Paxil (paroxetine) in 1992. These medications, known as selective serotonin reuptake inhibitors (SSRIs), target serotonin levels in the brain and usually have fewer side effects than their predecessors. Newer antidepressant drugs that have emerged in the past couple of decades include atypical antidepressants such as Wellbutrin (bupropion), Trintellix (vortioxetine), and serotonin-norepinephrine reuptake inhibitors (SNRIs). The 5 Major Classes of Antidepressants Our Understanding of Depression Today The term major depressive disorder (MDD) was first introduced by clinicians in the United States during the 1970s. The condition officially became part of the DSM-III in 1980. The current edition of the diagnostic manual is the DSM-5 and is one of the primary tools used in the diagnosis of depressive disorders. While the condition is much better understood today than it was in the past, researchers are still working to learn more about the causes of depression. At the present time, doctors believe that depression arises from a combination of multiple causes including biological, psychological, and social factors. Causes and Risk Factors of Depression Modern views of depression incorporate an understanding of the many symptoms of this condition as well as the often cyclical effect that the symptoms can have. For example, depression can cause disturbances in sleep, appetite, and activity levels; in turn, poor sleep, diet, and exercise can exacerbate symptoms of depression. In addition to considering the psychological factors that contribute to depression, doctors are also aware that certain medical conditions such as hypothyroidism may cause depressive symptoms. The diagnosis of depression includes ruling out other medical conditions and other possible causes such as alcohol or substance use. How Depression Is Diagnosed With the DSM-5 Thanks to the improved understanding of the causes of depression, effective treatments have emerged. Psychotherapy and medications that target molecules called neurotransmitters are generally the preferred treatments, although electroconvulsive therapy may be utilized in certain instances, such as in treatment-resistant depression or severe cases where immediate relief is required. Other, newer, therapies, including transcranial magnetic stimulation and vagus nerve stimulation, have also been developed in recent years in an attempt to help those who have failed to respond to therapy and medications. Unfortunately, the causes of depression are more complex than we yet understand, with no single treatment providing satisfactory results for everyone. Because depression is such a complex condition, mental health professionals often recommend a treatment approach that includes medications, psychotherapies, and lifestyle modifications. Tips for Living With Depression 14 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Reynolds EH, Wilson JV. Depression and anxiety in Babylon. J R Soc Med. 2013;106(12):478-481. doi:10.1177/0141076813486262 Tipton CM. 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The biomedical model of mental disorder: A critical analysis of its validity, utility, and effects on psychotherapy research. Clinical Psychology Review. 2013;33:846-861. doi:10.1016/j.cpr.2012.09.007 Health. Hysteria, Demons, and More: Depression Throughout History. Health Media Ventures. Inc. Hillhouse TM, Porter JH. A brief history of the development of antidepressant drugs: From monoamines to glutamate. Exp Clin Psychopharmacol. 2015;23(1):1-21. doi:10.1037/a0038550 Nemade R, Reiss NS, Dombeck M. Major Depression and Other Unipolar Depressions. CenterSite, LLC. Sober Media Group. The Economist. Depression Through the Ages: Melancholy Journey. The Economist Newspaper Limited. By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. 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