Why Some People Are More Prone to Depression Than Others

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Why does one person become depressed but another does not—even when they are under the same circumstances? Figuring out what makes someone more prone to depression continues to be one of the most pressing questions for researchers and mental health professionals.

Although researchers don’t have an exact answer as to why some people are more prone to depression than others, there's likely more than one causative factor. Research has implicated everything from physical and chemical differences in the brain to social and environmental risk factors.

The complexity of depression is what makes it a challenging condition to diagnose and treat. Understanding what could make a person more likely to experience depression is the first step in developing prevention and treatment strategies tailored to reduce individual vulnerability to the condition. 

Developing a more complete understanding of the various mechanisms that drive depression could also help researchers get better at predicting who will get depressed as well as predicting how the condition will manifest (the course it will take).

With this information, mental health professionals would be better prepared to predict how a person might respond to antidepressants or other forms of therapeutic treatment.  

What Causes Depression? 

According to the World Health Organization, over 300 million people worldwide live with depression. While the experience of depression is shared by many all over the world, the contributing factors will be different for each person with the condition. 

Causes of depression
Illustration by Joshua Seong. © Verywell, 2018.

There are some factors, like genetics, that you don’t have control over. However, there are others, such as your diet, that are more modifiable. While making a change can't necessarily prevent depression, it may help reduce your risk. 

Whether you can change them or not, it's helpful to be aware of factors that could make you more likely to develop depression in your lifetime. Just remember that researchers are still figuring out the role each factor plays. Having one—or even several—of the factors thought to contribute to depression doesn’t mean you will definitely become depressed. 

Still, depression is common in people of all ages, races, gender identities, and socioeconomic status. According to the 2017 report from the National Institute of Mental Health, depression affects approximately 17.3 million people in the United States. In 2018, the CDC reported that approximately 1.9 million children (ages 3-17) in the U.S. have been diagnosed with depression.

Biology and Genetics

Brain Chemistry 

Researchers don't agree on the exact way brain chemicals relate to depression, but the connection has been discussed for many decades. Some theories that have been around for a long time assumed that low levels of neurotransmitters (which the brain cells use to send signals to each other) could cause depression.

Other researchers have proposed that being depressed causes low levels, rather than it being the other way around. The relationship may even go both ways. 

What is known is that some people with depression feel better when they take medications that work on these neurotransmitters. However, researchers aren’t convinced this is enough to prove the relationship between brain chemistry and depression, in large part because some people with depression don’t feel better when they take antidepressants

Altering the levels of one neurotransmitter can have risks: for example, if the brain has too much serotonin (which can happen if a person is taking an antidepressant that acts on serotonin plus other medications or supplements that do as well) it can lead to a potentially serious condition called serotonin syndrome.


Researchers know that people who have family members who are depressed are more likely to become depressed. However, having a family history of depression doesn’t mean someone will definitely get depressed in their lifetime. There are still other factors that have to line up in order for a genetic predisposition to result in depression.

A large genome-wide study published in The American Journal of Psychiatry in 2019 found that people with a genetic predisposition for mental illness may be at a higher risk of attempting suicide regardless of which disorder they have.

Chronic Pain and Illness

Depression is common in people living with chronic illnesses such as multiple sclerosis, type 2 diabetes, and migraines. Research has shown that chronic pain conditions may cause biochemical changes that lead to symptoms of depression.

A person with chronic pain and illness may become depressed due to their situation, especially when they are facing a loss of quality of life, a reduced level of day-to-day functioning, prolonged pain, and/or death.

It’s also been shown that people who are diagnosed with one mental illness are more likely to develop another. Conditions such as anxiety and depression commonly co-occur.

While different mental health conditions may be diagnosed at the same time and can influence one another, they may need to be treated in different ways. 


Certain hormonal shifts can increase your risk of depression. For example, the hormonal changes associated with the menstrual cycle, pregnancy, giving birth, and menopause can all contribute to depression. 

The Centers for Disease Control and Prevention (CDC) estimates that around 1 in 9 women in the U.S. report experiencing postpartum depression. Approximately 4% of fathers report depression in the first year after a child is born. 

It’s also not unusual for people with thyroid conditions to experience depression. While symptoms tend to be more common in people with a low-functioning thyroid (hypothyroidism) people with an overactive thyroid (hyperthyroidism) can also experience anxiety and depression.

Living Environment & Exposures

Early Trauma and Abuse

One of the more well-studied depression risk factors is trauma in early childhood. Adverse Childhood Experiences (ACEs) are known to increase a person’s lifetime risk of developing both mental and chronic physical illness, including depression. 

Research into ACEs is ongoing, but previous studies have confirmed a strong link between specific childhood experiences and depression later in life. 

The CDC groups ACEs into three types:

  • Abuse (physical, emotional, sexual)
  • Neglect (physical, emotional)
  • Household Dysfunction (divorce, substance use, a parent who is mentally ill/incarcerated/being abused by another)

An individual’s ACE score is strongly linked to their risk of mental and physical illness, poverty, and even early death. Risk increases as the number of ACEs increases. A person with four or more ACEs is at the highest risk.

Researchers believe that child abuse may change the brain physically, as well as alter its connectivity structure. Studies have also shown that neuroendocrine function may be altered in people who experienced high levels of stress as children.

A 2019 study from the Massachusetts General Hospital has even proposed that traumatic experiences in the first three years of life may even change a child's DNA.


According to the 2017 survey from the American Psychological Association, 64% of American adults said money was a significant source of stress in their lives. People living in poverty were twice as likely to have depression compared to those living at or above the poverty level.

Not only does living in poverty place a person at higher risk for depression but if they are unable to work or do not have access to support and social services, mental illness can make it harder for someone to break out of a cycle of socioeconomic disadvantage.  

Several studies and pilot programs have shown that when people with mental illness were given financial assistance, symptoms of depression and anxiety improved. 

Environmental Exposures

Where a person lives can have an impact on mental health in a number of ways. For example, some people report they become depressed during certain months of the year, sometimes called seasonal affective disorder (SAD).

There are also studies that cite pollution and other environmental exposures as potential contributing factors to depression.  For example, some research has linked lead exposure in childhood to poor mental health later in life.

In another study, children who grew up in areas with poor air quality appeared to be more likely to be depressed or be diagnosed with conduct disorder by the time they turned 18.

Your environment can also be an asset to your mental health. Research has shown that spending time in nature can also help people cope with depression. One study found kids who spent time in nature had better mental health as adults.

Social & Lifestyle


Certain personality traits, including low self-esteem, pessimism, neuroticism, and being self-critical or "a perfectionist" have been associated with a greater tendency toward depression and other mental health conditions, such as anxiety and eating disorders.

Researchers are especially interested in learning more about a personality trait that may make someone less likely to experience depression. Resilience, or the qualities or traits that make some people more likely to “bounce back” from adverse experiences, may also be key to preventing and treating depression.

Stress and Conflict

Major life events—and that can include "good" events like getting married or "bad" events like losing a job—can all create stress. When we are stressed, our cortisol levels rise. One theory is that high levels of cortisol (especially when they are chronically elevated) could affect serotonin levels.

Work-related stress, in particular, can be a driver of depression. Losing a job is an obvious stressor, but the work environment can also contribute to stress—especially if it doesn't feel supportive.

According to polls conducted by the American Psychiatric Association in 2017, 2018, and 2019, only half of U.S. workers report feeling that they can discuss mental health openly at work. 

Conflict at work or school can also make it more likely a person will become depressed. A 2010 study in Japan linked interpersonal conflict at work to depression (particularly among male employees with a higher socioeconomic status).

The year before, researchers in Sweden had published a study showing that having serious conflicts with coworkers or bosses, and/or feeling excluded or left out at work, contributed to depression in employees.

It’s not just adults who experience conflict away from home: kids and teens can encounter interpersonal challenges at school which have the potential to affect their short and long term mental and physical health. 

A 2017 report from the National Center for Education Statistics found that 20% of students between the ages 12-18 said they had been bullied at school in the previous year.

According to the CDC, kids who are bullied are more likely to experience mental health problems, including anxiety and depression. They’re also more likely to have physical ailments, particularly headaches and stomachaches. 

Going through conflicts with friends and/or family may also increase the chances that a person who is prone to depression will develop the condition.

While fighting can put a strain on relationships, several studies have indicated romantic partners might be more influenced by how supported they feel by a partner rather than how often they fight. 

In a study from 2010, researchers noted that when asked about relationship satisfaction, romantic partners felt the level of support between themselves and their partner had more of an impact than the level of conflict.

Researchers want to learn more about this process, as well as whether genetic determinants can make someone more resilient to the effects of stress.


Grieving is a process that can look and feel like depression, except that it usually follows a particular time frame beginning with an event (such as the death of a loved one) and gradually moving toward resolution or a stage of acceptance.

Researchers are learning, though, that bereavement can take on the qualities of a condition similar to clinical depression, particularly in terms of how long it persists for (years as opposed to months).

Complicated grief, as it is often termed, appears to be more likely when someone loses a loved one in a sudden, unexpected, and especially violent way (such as a car accident).

Additional studies are needed to formally define complicated grief as a distinct condition, but it’s an apparent relationship to depression, as well as post-traumatic stress disorder (PTSD) is frequently noted by researchers.

The stress caused by a death, major loss, or another life stressor can be enough to trigger an episode of depression in someone who already possesses the tendency towards this condition.

Social Media

While the research is still fairly new and ongoing, many studies have investigated the effect of social media on mental health, especially in young people. 

Several studies have indicated that social media use can trigger depressive symptoms and anxiety through insecurity, comparison, “fear of missing out,” and bullying/harassment (which, whether experienced in-person or online, raises a child’s lifetime risk for depression).   

Overuse of social media may also contribute to depression by reducing a person’s level of physical activity and real-life interaction. A sedentary lifestyle and being socially isolated are two factors that can contribute to poor mental health independent of social media habits.  

The research hasn’t been all bad, though. Technology, the internet, and social media may also prove useful for helping to detect and manage depression.

Prescription Medications

Certain medications are known to have the potential to increase a person’s risk of depression, including:

Medications used to treat mental illness and sleep disorders can also worsen or cause depression in some people. People under the age of 25 are especially at risk for increased depression and suicidality after starting certain antidepressants. Therefore, the FDA has given these medications a black box warning

Substance Use

It’s not uncommon for people with mental illness to self-medicate with drugs and alcohol. However, it’s also important to note that not unlike prescription medications, certain illegal drugs can also make a person feel depressed. 

According to data from the National Alliance on Mental Health’s Drug and Health Survey, 7.9 million people in the U.S. were living with both depression and a substance use disorder in 2014. 

When substance use and depression occur at the same time (sometimes called “dual diagnosis) it can be difficult to find the right treatment. People often need a diverse team of support from doctors, therapists, and addiction treatment specialists to help them recover.

If a person needs to withdraw from a substance, it's sometimes safest for them to do so under medical care. Treatment at a mental health facility can also help a person address both substance use disorders and symptoms of depression that may accompany them. 

Diet and Physical Activity

Recent studies have indicated that adults with mild depression may be able to prevent an episode of major depression through a combination of lifestyle changes.

Gut microbes and diet may also play a role in the development of depression. Some research has shown that certain diets, such as the Mediterranean diet, might help older adults avoid depression. 

Diets that are high in sugar and trans fat, especially heavily processed food, can promote or worsen depression, especially when paired with a sedentary lifestyle.  A possible reason for the link is that diets high in these foods can lead to weight gain.

A 2018 study found that people were more likely to become depressed if they were overweight—even if the extra weight wasn’t causing them to have other health problems such as high blood pressure or type 2 diabetes.

The benefits of exercise for our health are well-known, but we are learning more about how exercising can help people with depression manage their symptoms.

Several recent studies confirmed previous research indicating that regular exercise and a healthy diet doesn’t just help people manage depression, but can help prevent it.

Children and young adults also benefit from eating well and getting regular physical activity. 

A Word From Verywell

Each person’s experience of living with depression will vary, as will the individual factors that contribute to the development and course of the condition. Mental illness is common and treatable, but it can take time to find the safest and most effective treatment for each person. People who have more than one co-occurring condition including substance use or physical health issues, benefit from a broad team of support. Working with doctors and mental health professionals, developing coping strategies at work and school, and having support from family and friends are of vital importance to every person living with depression, as well as those with risk factors for developing the condition in their lifetime. 

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