Zoloft as Treatment for Social Anxiety Disorder

Table of Contents
View All
Table of Contents

Zoloft is the brand name of the generic medication sertraline hydrochloride, a prescription medication used to treat depression, anxiety disorders, and other serious mental health problems. Manufactured by Pfizer, Zoloft is approved by the Food and Drug Administration (FDA) for the treatment of social anxiety disorder and is the only medication approved for long-term treatment.

A selective serotonin reuptake inhibitor (SSRI), Zoloft slows reabsorption of the chemical serotonin in the brain. Serotonin is believed to play a role in the regulation of mood and anxiety.

how to take zoloft
Illustration by Alexandra Gordon, Verywell

How to Take Zoloft

Zoloft comes in tablet or liquid form. You must swallow the tablets whole—not chewed or crushed.

You must combine the liquid form of Zoloft with one of the following before use: water, ginger ale, lemon-lime soda, lemonade, or orange juice. Combine the prescribed amount of medication with one-half cup of the chosen liquid, and be sure to prepare each dose immediately before you take it, not in advance.

In general, Zoloft is taken once daily, with or without food. If you forget to take a daily dose, take it when you remember. However, if it is close to the time of your next dose, it is better to skip the missed dose altogether.

Take the medication as directed until your healthcare provider provides other guidance. Your doctor will slowly taper your dosage when you stop taking Zoloft. Discontinuing the medication on your own could lead to troubling symptoms.

It is important to continue taking Zoloft as long as your doctor instructs, even if you begin to feel better. If you abruptly stop taking Zoloft, you may experience withdrawal symptoms such as nausea, tremors, lightheadedness, muscle pains, weakness, insomnia, and anxiety.


For people with social anxiety disorder, a typical dosage of Zoloft starts at 25 mg, with an increase to 50 mg after one week. Weekly increases up to a maximum dose of 200 mg are permitted for patients who do not respond to lower doses.


Zoloft should be used with caution if you:

  • Are allergic to sertraline
  • Are being treated with medication for alcohol abuse
  • Are breastfeeding
  • Are pregnant or planning to become pregnant
  • Have a bipolar disorder or a family history of bipolar disorder
  • Have impaired liver or kidney function, heart disease, diabetes, or a history of seizures

Zoloft has not been approved for the treatment of social anxiety disorder in people under 18 years of age. There is some evidence to suggest an increased risk of suicidal thoughts and behaviors in children taking Zoloft.

If you or your child are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 1-800-273-8255 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.

For more mental health resources, see our National Helpline Database.

Medication Interactions

Zoloft should not be taken in combination with, or within weeks of taking monoamine oxidase inhibitors (MAOIs). The use of Zoloft with pimozide is contraindicated.

Use caution when taking a number of other medications in combination with Zoloft. Consumption of alcohol is also not advised while taking Zoloft. In general, you should tell your doctor about any prescription or over-the-counter medications, or any other substances that you are taking or plan to take.

Side Effects

Side effects of Zoloft can range from mild to more serious. Zoloft may make you feel drowsy and less alert. It is important not to drive, operate dangerous machinery, or participate in hazardous activities unless you are sure that Zoloft is not affecting you in this way.

Side effects of Zoloft may include nausea, drowsiness, sweating, dizziness, dry mouth, diarrhea, decreased appetite, sexual dysfunction, and insomnia.

When first starting Zoloft, or when changing dosage, watch for more serious side effects such as agitation, nervousness, suicidal thoughts and behaviors, tremors, seizures, persistent vomiting or nausea, severe abdominal pain, changes in urine or stools (dark or increased urine, black stools), or yellowing of the eyes or skin. If you experience any of these symptoms, report them to your doctor right away.

It is also important to contact your doctor right away if you experience symptoms of a serious allergic reaction. These symptoms may include trouble breathing, severe dizziness, swelling, itching, or a skin rash.

Associated Risks

The risk of a fatal overdose of Zoloft is low. Symptoms of an overdose include dizziness, drowsiness, nausea, vomiting, increased or slow heart rate, and coma.

When combined with some medications, there is a ​risk of serotonin syndrome, a potentially fatal condition. Symptoms of serotonin syndrome include agitation, confusion, sweating, hallucinations, abnormal reflexes, muscle spasms, and rapid heartbeat.

Was this page helpful?
Article Sources
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. U.S. National Library of Medicine, National Institute of Health. ZOLOFT- sertraline hydrochloride tablet. Updated September 20, 2019.

  2. Pfizer. Zoloft: tablets and oral concentrate. Updated August 2011.

  3. Gabriel M, Sharma V. Antidepressant discontinuation syndrome. CMAJ. 2017;189(21):E747. doi:10.1503/cmaj.160991

  4. Pfizer. Zoloft (sertraline hydrochloride) tablets, oral solution. Updated January 2018.

  5. Simon LV. Serotonin syndrome. National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine, NIH. Published September 29, 2019. 

  6. Foong AL, Grindrod KA, Patel T, Kellar J. Demystifying serotonin syndromeCan Fam Physician. 2018;64(10):720-727. PMID: 30315014